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glyphosate (Roundup)

active cpd in herbicidal formulation Roundup; inhibits EC 2.5.1.19, 5-enolpyruvylshikimate-3-phosphate synthase; structure

Also Known As:

Roundup; N-(phosphonomethyl)glycine; gliphosate; glyphosate hydrochloride (2:1); glyphosate, calcium salt; glyphosate, calcium salt (1:1); glyphosate, copper (2+) salt; glyphosate, dilithium salt; glyphosate, disodium salt; glyphosate, magnesium salt; glyphosate, magnesium salt (2:1); glyphosate, monoammonium salt; glyphosate, monopotassium salt; glyphosate, monosodium salt; glyphosate, sodium salt; glyphosate, zinc salt

Networked: 150 relevant articles (1 outcomes, 19 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins
- Amino Acids: 10808
  - Glycine: 3656
    - glyphosate: 150

Experts

1.	Seneff, Stephanie: 3 articles (01/2015 - 12/2013)
2.	Shukla, Yogeshwer: 3 articles (01/2013 - 01/2009)
3.	Mohamed, Fahim: 3 articles (12/2012 - 09/2009)
4.	Eddleston, Michael: 3 articles (12/2012 - 09/2009)
5.	Séralini, Gilles-Eric: 3 articles (11/2012 - 01/2009)
6.	Clair, Emilie: 3 articles (11/2012 - 01/2010)
7.	Samsel, Anthony: 2 articles (01/2015 - 12/2013)
8.	Liu, Sen: 2 articles (01/2015 - 01/2013)
9.	Zhang, Qiuyang: 2 articles (01/2015 - 01/2013)
10.	You, Zongbing: 2 articles (01/2015 - 01/2013)

Related Diseases

1.	Body Weight (Weight, Body) 10/01/2011 - "biloba provided significant protection against glyphosate-induced toxicity, and the strongest effect was observed at a dose of 150 mg/kg of body weight. " 10/01/2011 - "biloba (150 mg/kg of body weight) and glyphosate (50 mg/kg of body weight). " 10/01/2011 - "biloba (50 mg/kg of body weight) and glyphosate (50 mg/kg of body weight), and Group VI received G. " 06/01/2004 - "Overall health, body weight, food consumption, clinical pathology parameters (hematology, blood chemistry, urinalysis), organ weights, gross and microscopic appearance of tissues were comparable between groups fed diets containing Roundup Ready and control corn grain. " 07/01/1991 - "Five groups of male Sprague-Dawley rats were orally administered a mixture of [14C]- and [12C]-glyphosate (N-phosphonomethylglycine) at a dose level of 10 mg/kg body weight. "
2.	Neoplasms (Cancer) 03/01/2015 - "The lack of a plausible mechanism, along with published epidemiology studies, which fail to demonstrate clear, statistically significant, unbiased and non-confounded associations between glyphosate and cancer of any single etiology, and a compelling weight of evidence, support the conclusion that glyphosate does not present concern with respect to carcinogenic potential in humans. " 03/01/2015 - "Evaluation of carcinogenic potential of the herbicide glyphosate, drawing on tumor incidence data from fourteen chronic/carcinogenicity rodent studies." 03/10/2010 - "Carcinogenicity study revealed that glyphosate has tumor promoting activity. " 01/01/2005 - "We evaluated associations between glyphosate exposure and cancer incidence in the Agricultural Health Study (AHS), a prospective cohort study of 57,311 licensed pesticide applicators in Iowa and North Carolina. " 01/01/2005 - "Cancer incidence among glyphosate-exposed pesticide applicators in the Agricultural Health Study."
3.	Poisoning 08/01/2010 - "The results of this study showed that age > 50 years, X-ray abnormalities, and ALT > 40 U/L were significant predictive factors for complications in patients with glyphosate surfactant herbicide poisoning; patients with these findings might require admission to the intensive care unit." 08/01/2009 - "The epidemiology of glyphosate-surfactant herbicide poisoning in Taiwan, 1986-2007: a poison center study." 04/18/2015 - "Glyphosate-surfactant herbicide poisoning in domestic animals: an epidemiological survey." 05/01/2014 - "Glyphosate surfactant herbicide poisoning and management." 03/10/2013 - "In 13 glyphosate poisoning cases treated in our laboratory within 7 years period from 2002 to 2009, we registered clinical observations and collected blood and urine samples to HPLC-MS-MS analysis. "
4.	Necrosis 11/16/2013 - "We demonstrate in addition that POE-15 induces necrosis when its first micellization process occurs, by contrast to glyphosate which is known to promote endocrine disrupting effects after entering cells. " 02/01/2013 - "The results support the possibility that mixtures of glyphosate and TN-20 aggravate mitochondrial damage and induce apoptosis and necrosis. " 02/01/2013 - "Mixtures of glyphosate and surfactant TN20 accelerate cell death via mitochondrial damage-induced apoptosis and necrosis." 03/01/2012 - "Within 24-48h this formulation is also toxic on the other cells, mainly by necrosis, by contrast to glyphosate alone which is essentially toxic on Sertoli cells. " 02/01/2009 - "The increased thickness in leaf blade and palisade parenchyma may be related to the plant response to glyphosate action, as a form of recovering the photosynthetically active area reduced by necroses and leaf senescence caused by the herbicide."
5.	Chromosome Aberrations (Chromosome Abnormalities) 01/01/2009 - "Therefore, in the present study, genotoxic effects of the herbicide glyphosate were analyzed by measuring chromosomal aberrations (CAs) and micronuclei (MN) in bone marrow cells of Swiss albino mice. " 04/01/2013 - "An overwhelming preponderance of negative results in well-conducted bacterial reversion and in vivo mammalian micronucleus and chromosomal aberration assays indicates that glyphosate and typical GBFs are not genotoxic in these core assays. " 11/01/2006 - "Roundup did not induce chromosomal aberrations or micronuclei in either test system. " 01/01/2006 - "A technical herbicide containing isopropyl amine salt of glyphosate was tested for induction of chromosome aberrations (CA) and sister chromatid exchanges (SCE) in cultured bovine peripheral lymphocytes. " 06/01/1993 - "The anaphase-telophase Allium test showed no effect for the glyphosate isopropylamine salt, but a significant increase in chromosome aberrations appeared after treatment with Roundup at concentrations of 1.44 and 2.88 mg/l when calculated as glyphosate isopropylamine. "

Related Drugs and Biologics

1.	glyphosate (Roundup)
2.	Herbicides
3.	Glutathione (Reduced Glutathione)
4.	Atrazine
5.	alpha- Amino- 3- hydroxy- 5- methyl- 4- isoxazolepropionic Acid (AMPA)
6.	Silver
7.	Nitric Oxide (Nitrogen Monoxide)
8.	Cysteine (L-Cysteine)
9.	Carbofuran (Furadan)
10.	metalaxyl

Related Therapies and Procedures

1.	Renal Dialysis (Hemodialysis)
2.	Intraperitoneal Injections
3.	Intramuscular Injections
4.	Canes (Cane)
5.	Aftercare (After-Treatment)