1,2-distearoyllecithin

Also Known As:

1,2-distearin sn-3-phosphorylcholine; 1,2-distearoyl-sn-glycero-3-phosphocholine; 1,2-distearoyllecithin, (+-)-isomer; 1,2-distearoyllecithin, (R)-isomer; 1,2-distearoyllecithin, (S)-isomer; 1,2-distearoylphosphatidylcholine; 4-hydroxy-N,N,N-trimethyl-10-oxo-7-((1-oxooctadecyl)oxy)-3,5,9-trioxa-4-phosphahepta cosan-1-aminium hydroxide, inner salt, 4-oxide; DL-DSPC; DSPC R-isomer; L-DSPC; L-distearoyllecithin; distearoyl phosphatidylcholine; distearoyl-sn-glycero-3-phosphocholine; distearoylglycerophosphocholine; distearoylphosphatidylcholine; distearoylphosphatidylcholine, DL-

Networked: 44 relevant articles (3 outcomes, 8 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Lipids: 114793
- Membrane Lipids: 1591
  - Phospholipids: 11903
    - Glycerophosphates: 118
      - Phosphatidic Acids: 358
        Glycerophospholipids: 689
        Phosphatidylcholines: 2371
        1,2-distearoyllecithin: 44

Experts

1.	Awad, Doaa: 2 articles (04/2015 - 01/2014)
2.	Gabel, Detlef: 2 articles (04/2015 - 01/2014)
3.	Schaffran, Tanja: 2 articles (04/2015 - 01/2014)
4.	Grace, V M Berlin: 2 articles (02/2013 - 12/2012)
5.	Siddikuzzaman,: 2 articles (02/2013 - 12/2012)
6.	Chen, Chi-An: 2 articles (01/2009 - 06/2006)
7.	Hsieh, Chang-Yao: 2 articles (01/2009 - 06/2006)
8.	Wei, Lin-Hung: 2 articles (01/2009 - 06/2006)
9.	Ji, Xiuling: 1 article (06/2019)
10.	Sun, Tao: 1 article (06/2019)

Related Diseases

1.	Neoplasms (Cancer) 12/01/2016 - "The proposed imaging sequence was able to achieve statistically significant detection (P < 0.05, n = 5) of VEGFR2 in tumors with a minimum MBVEGFR2 injection dose of only 5 × 10 microbubbles per mouse (distearoyl phosphatidylcholine at 0.053 ng/g mouse body mass). " 10/01/2016 - "In this study, molecular interactions between the anti-cancer agent 20(R)-25-methoxyl-dammarane-3β, 12β, 20-triol (AD-1) and phospholipid 1,2-Distearoyl-sn-glycero-3-phosphocholine (DSPC) were investigated using the Langmuir film balance technique. " 01/01/2011 - "Liposomal HDACI-lipid conjugates were prepared with distearoylphosphatidylcholine (DSPC) and HDACI-Chol conjugate or with DSPC, Chol and HDACI-PEG-lipid conjugates, and their cytotoxicities were evaluated for human cervix tumor HeLa and mouse colon tumor Colon 26 cells. " 07/27/2000 - "Whereas, for the treatment of solid tumor and the reduction of side effects, L-alpha-distearoylphosphatidylcholine-containing liposomes were most effective. " 11/01/1999 - "Using a stable liposomal system composed of distearoyl phosphatidylcholine/cholesterol, we examined the effect of PEG (Mr 2000) on the pharmacokinetics and on the efficacy of liposomal doxorubicin with C-26 syngeneic tumor model in BALB/c mice. "
2.	Visceral Leishmaniasis (Kala Azar) 03/01/2008 - "In this study, we showed that cationic distearoyl phosphatidylcholine (DSPC) liposomes, when used as vaccine adjuvant with the immunodominant 63-kDa glycoprotein (gp63) of Leishmania donovani promastigotes, induced significant protection against progressive visceral leishmaniasis in susceptible BALB/c mice. "
3.	Inflammation (Inflammations) 02/01/2013 - "The study was also focused on its inhibitory effect on the acute and chronic inflammation and tumor-associated capillary formation in terms of angiogenesis in C57BL/6 mice after incorporated in liposome composed of distearoylphosphatidylcholine (DSPC/cholesterol). " 06/25/2019 - "In this study, we employed a boundary lubricant known as a 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC) liposome for loading of an anti-inflammatory drug d-glucosamine sulphate (GAS) to construct a treatment strategy allowing for sustained anti-inflammation and reduced damage. "
4.	Lung Neoplasms (Lung Cancer) 09/01/2017 - "Hence we have used 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC) and cholesterol lipo-ATRA to investigate its molecular therapeutic effect on lung cancer. " 12/01/2012 - "The purpose of this study was to investigate whether all trans retinoic acid (ATRA) incorporated in liposome composed of distearoylphosphatidylcholine (DSPC/cholesterol) could inhibit the metastatic lung cancer in mice more efficiently than free ATRA. "
5.	Ovarian Neoplasms (Ovarian Cancer) 01/01/2009 - "Phase II trial of carboplatin and distearoylphosphatidylcholine pegylated liposomal doxorubicin (Lipo-Dox) in recurrent platinum-sensitive ovarian cancer following front-line therapy with paclitaxel and platinum."

Related Drugs and Biologics

1.	Liposomes (Liposome)
2.	Cholesterol
3.	Phospholipids (Phosphatides)
4.	liposomal doxorubicin (Doxil)
5.	Glycoproteins (Glycoprotein)
6.	Vaccine Adjuvants
7.	1,2-Dipalmitoylphosphatidylcholine (Dipalmitoylphosphatidylcholine)
8.	Technetium (Technetium 99m)
9.	Platinum
10.	Carboplatin (JM8)

Related Therapies and Procedures

1.	Therapeutics
2.	Fluid Therapy (Oral Rehydration Therapy)
3.	Injections
4.	Intravenous Administration
5.	Microbubbles