discretamine (scoulerine)

structure

Also Known As:

scoulerine; aequaline; aequaline, (S)-isomer; discretamine, (+-)-isomer; discretamine, (R)-isomer; discretamine, (S)-isomer; discretamine, hydrochloride, (S)-isomer; scoulerine, (S)-isomer; 6H-dibenzo(a,g)quinolizine-2,9-diol, 5,8,13,13a-tetrahydro-3,10-dimethoxy-

Networked: 7 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Alkaloids: 5398
  - Benzylisoquinolines: 151
    - Berberine Alkaloids: 9
      - discretamine: 7
- Fused-Ring Heterocyclic Compounds
  - 4 or More Rings Heterocyclic Compounds
    - Berberine Alkaloids: 9
      - discretamine: 7

Experts

1.	Klobukowski, Mariusz: 1 article (06/2022)
2.	Michalak, Marek: 1 article (06/2022)
3.	Moshari, Mahshad: 1 article (06/2022)
4.	Tuszynski, Jack Adam: 1 article (06/2022)
5.	Wang, Qian: 1 article (06/2022)
6.	Ahire, Vidhula: 1 article (01/2021)
7.	Allen, Thaddeus D: 1 article (01/2021)
8.	Li, Hongmei: 1 article (01/2021)
9.	Li, Jinhua: 1 article (01/2021)
10.	Nimishetti, Naganna: 1 article (01/2021)

Related Diseases

1.	Carcinoma (Carcinomatosis) 09/01/2023 - "Scoulerine, a benzylisoquinoline alkaloid, has been reported effective against several carcinomas. "
2.	Neoplasms (Cancer) 09/01/2023 - "In vivo studies revealed a substantial decrease in tumor mass and volume after scoulerine treatment. " 01/01/2021 - "Collectively, these findings uncover a previously unknown activity of scoulerine that could facilitate targeting human cancers. " 01/01/2021 - "Scoulerine inhibited the viability of a variety of human cancer cell lines. " 01/01/2018 - "Scoulerine affects microtubule structure, inhibits proliferation, arrests cell cycle and thus culminates in the apoptotic death of cancer cells." 06/21/2022 - "Scoulerine is a natural compound that is known to bind to tubulin and has anti-mitotic properties demonstrated in various cancer cells. "
3.	Colorectal Neoplasms (Colorectal Cancer) 08/25/2020 - "However, the effects and underlying mechanisms of scoulerine on colorectal cancer (CRC) progression remain elusive. " 08/25/2020 - "Scoulerine promotes cell viability reduction and apoptosis by activating ROS-dependent endoplasmic reticulum stress in colorectal cancer cells."
4.	Tachycardia (Tachyarrhythmias) 05/01/2009 - "In normotensive non-anaesthetized rats (n = 6), discretamine (0.01; 0.05; 0.1; 0.5; 1, 5 and 10 mg/kg i.v., randomly) injections produced hypotension (-5.2 +/- 1.7; -5.1 +/- 2.1; -7.7 +/- 2; -8.9 +/- 1.7; -9.6 +/- 2.2; -16.8 +/- 2.8 and -13.4 +/- 1.3 mmHg, respectively) accompanied by tachycardia (24.2 +/- 6.1; 36.8 +/- 11.3; 44.2 +/- 7.7; 45.9 +/- 6.4; 48.2 +/- 9.1; 72.1 +/- 14.5 and 64 +/- 17 bpm, respectively). "
5.	Polyploidy 01/01/2021 - "Mechanistically, scoulerine inhibited AURKB activity at concentrations that elicited supernumerary centrosomes and polyploidy. " 01/01/2021 - "A known alkaloid, scoulerine, was identified from the rhizomes of the plant Corydalis decumbens as being able to elicit a transient mitotic arrest followed by either apoptosis induction or polyploidy. "

Related Drugs and Biologics

1.	Alkaloids
2.	Benzylisoquinolines
3.	isoquinoline
4.	Aurora Kinases
5.	Tubulin
6.	Proteins (Proteins, Gene)
7.	Phosphotransferases (Kinase)
8.	Hesperidin
9.	Antineoplastic Agents (Antineoplastics)
10.	corynoline

Related Therapies and Procedures

1.	Injections