HOME
PRODUCTS
COMPANY
CONTACT
FAQ
Research
Dictionary
Pharma
Sign Up
FREE
or
Login
Username:
Password:
Remember login
Login
Send password reminder...
bufuralol
RN given refers to cpd without isomeric designation; structure
Also Known As:
Ro 3-4787; bufuralol, (DL)-(+-)-isomer; bufuralol, hydrochloride; bufuralol, hydrochloride, (D)-(+)-isomer; bufuralol, hydrochloride, (DL)-(+-)-isomer; bufuralol, hydrochloride, (L)-(-)-isomer; 1-(7-ethylbenzofuran-2-yl)-2-tert-butylamino-1-hydroxyethane
Networked:
13
relevant articles (
1
outcomes,
0
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Organic Chemicals: 133
Amines: 4871
Amino Alcohols: 20
Ethanolamines: 16
bufuralol: 13
Alcohols: 595
Ethanol: 23169
Ethanolamines: 16
bufuralol: 13
Amino Alcohols: 20
Ethanolamines: 16
bufuralol: 13
Experts
1.
Bodor, N
: 2 articles (04/2000 - 03/2000)
2.
Hwang, S K
: 1 article (04/2000)
3.
Juhasz, A
: 1 article (04/2000)
4.
Yoon, S H
: 1 article (04/2000)
5.
Juhász, A
: 1 article (03/2000)
Related Diseases
1.
Renal Insufficiency (Renal Failure)
10/01/1980 - "
Influence of renal failure on the hepatic clearance of bufuralol in man.
"
10/01/1980 - "
From this analysis it appears that the presystemic biotransformation of bufuralol is decreased in renal failure and that changes in systemic clearance are compensated in our patients by modifications of the volume of distribution, resulting in little net change in the halflife of elimination.
"
10/01/1980 - "
The behavior of bufuralol in patients with renal failure was analyzed using the clearance approach.
"
2.
Tachycardia (Tachyarrhythmias)
01/01/1984 - "
In anaesthetised animals both bufuralol and its metabolite exhibited partial agonistic activity, resulting in tachycardia and vasodilation.
"
04/20/2000 - "
In the isoproterenol-induced tachycardia model, while bufuralol at an iv dose of 1 mg/kg (3.8 micromol/kg) diminished heart rate (HR) for at least 2 h, the effects of the soft drugs lasted for only 10-30 min at equimolar dose.
"
03/01/2000 - "
In the isoproterenol-induced tachycardia model, while bufuralol at an i.v. dose of 3.8 mumol/kg (1 mg/kg) diminished heart rate (HR) for at least 2 h, the effects of the soft drugs lasted for only 30-40 min at equimolar doses.
"
11/01/1986 - "
Bufuralol 60 and 120 mg produced similar reduction in exercise tachycardia as propranolol 40 mg but less than propranolol 160 mg. Plasma levels of bufuralol and its two major metabolites were measured.
"
01/01/1986 - "
All three beta-adrenoceptor antagonists reduced exercise tachycardia, but at the doses chosen the effects of bufuralol were less than those of propranolol.
"
3.
Stable Angina
05/01/1984 - "
Simultaneous hemodynamic and equilibrium radionuclide function measurements were performed at rest and during exercise before and 75 min after oral administration of 30 mg bufuralol, a nonselective beta-adrenoceptor blocking drug, in 10 patients with stable angina pectoris.
"
4.
Autoimmune Hepatitis
11/01/1988 - "
Anti-LKM1 titers follow the severity of the disease and the presence of these antibodies serves as a diagnostic marker for this autoimmune hepatitis type II. We demonstrate that anti-LKM1 IgGs specifically inhibit the hydroxylation of bufuralol in human liver microsomes.
"
5.
Myocardial Ischemia (Ischemic Heart Diseases)
01/01/1986 - "
To assess acute hemodynamic effects of bisoprolol on left ventricular hemodynamics at rest and during exercise, 16 patients with documented chronic ischemic heart disease were studied and compared with patients after administration of metoprolol and bufuralol.
"
01/01/1986 - "
Effects of bisoprolol in relation to metoprolol and bufuralol on left ventricular hemodynamics at rest and during exercise in chronic ischemic heart disease.
"
Related Drugs and Biologics
1.
Propranolol (Inderal)
2.
Isoproterenol (Isoprenaline)
3.
Mixed Function Oxygenases (Monooxygenases)
4.
Bisoprolol (Concor)
5.
Warfarin (Coumadin)
6.
Adrenergic Receptors (Adrenergic Receptor)
7.
Radioisotopes (Radionuclides)
8.
Proteins (Proteins, Gene)
9.
Phenobarbital (Luminal)
10.
Metoprolol (Toprol-XL)
Related Therapies and Procedures
1.
Oral Administration