reticulol

06/01/2003 - "Reticulol administered via the peritoneum of mice showed less metastasis inhibition than that injected intravenously. "
06/01/2003 - "The in vivo assay for the lung metastasis-blocking effect showed that reticulol injected intravenously suppressed the increase in colonies on the lung in a dose-dependent manner. "
06/01/2003 - "Antitumor efficacy of reticulol from Streptoverticillium against the lung metastasis model B16F10 melanoma. "
06/01/2003 - "These results suggest that reticulol protects its lung metastasis via the bloodstream by inhibiting the growth of B16F10 melanoma at the cellular level."
06/01/2003 - "To demonstrate the mechanism for inhibition of metastasis, the inhibitory effect of reticulol for matrix metalloproteinase-2 or -9 involved in melanoma metastasis was investigated; however, they were not observed on zymogram gel. "

06/01/2003 - "Antitumor efficacy of reticulol from Streptoverticillium against the lung metastasis model B16F10 melanoma. "
06/01/2003 - "These results suggest that reticulol protects its lung metastasis via the bloodstream by inhibiting the growth of B16F10 melanoma at the cellular level."
09/01/2003 - "Topoisomerase I inactivation by reticulol and its in vivo cytotoxicity against B16F10 melanoma."
06/01/2003 - "Therefore, it was inferred that reticulol known as a phosphodiesterase inhibitor directly inhibited the growth of B16F10 melanoma, showing necrotic response. "
06/01/2003 - "To demonstrate the mechanism for inhibition of metastasis, the inhibitory effect of reticulol for matrix metalloproteinase-2 or -9 involved in melanoma metastasis was investigated; however, they were not observed on zymogram gel. "

06/01/2003 - "In addition, the survival rate of tumor-implanted mice treated with reticulol was closely associated with its antitumoral efficacy. "
09/01/2003 - "Furthermore, from the in vivo assay, reticulol combined with Adriamycin (a mixture with retinolol 5 mg/kg and Adriamycin 1 mg/kg) further retarded the tumor growth compared to that in mice treated with Adriamycin alone (1 mg/kg). "
09/01/2003 - "Taken together, these results suggested that reticulol inactivates Topo I, which is involved in tumor metastasis, and exhibits excellent cytotoxic efficacy against B16F10 melanoma, when combined with Adriamycin, in a mouse model."

09/01/2003 - "In the annexin V/propidium iodide staining assay to investigate the death pattern of B16F10 cells treated with 200 microM reticulol, proliferation of B16F10 cells was inhibited due to necrosis. "