narciclasine

01/01/2020 - "The histopathological studies showed that narciclasine prevents the organ damage associated with sepsis and improved the survival of neonatal rats. "
01/01/2021 - "The present study aimed to investigate the underlying mechanism by which narciclasine affects the pathogenesis of sepsis-induced myocardial injury. "
01/01/2021 - "Taken together, our findings indicate that narciclasine protects against LPS-induced AMI by inducing JNK-dependent autophagic flux; hence, narciclasine may be an effective and novel agent for the clinical treatment of sepsis-induced myocardial injury."
01/01/2021 - "Narciclasine attenuates sepsis-induced myocardial injury by modulating autophagy."
01/01/2020 - "Narciclasine improves outcome in sepsis among neonatal rats via inhibition of calprotectin and alleviating inflammatory responses."

02/26/2009 - "Data generated in the present study show that narciclasine displays potent antitumor effects in apoptosis-resistant as well as in apoptosis-sensitive cancer cells by impairing the organization of the actin cytoskeleton in cancer cells at concentrations that are not cytotoxic (IC(50) values of 30-90 nM). "
03/17/2022 - "Narciclasine (Nar) possesses strong inhibiting effects against a variety of cancer cells; however, the underlying antitumor target(s)/mechanism(s) remains barely understood. "
03/01/2020 - "From our results, narciclasine appears to hold the potential of a lead molecule that can be used to bridge the therapeutic gaps in cancer research."
11/01/2016 - "However, narciclasine did not show a strong pharmacological activity in animal tumor models. "
11/01/2016 - "Due to its selective and highly potent cytotoxic action on cancer cells, narciclasine was intensively investigated as an antitumor compound both in vitro and in vivo. "

01/01/2021 - "Narciclasine effectively attenuated LPS-induced myocardial inflammation in vitro and in vivo. "
12/01/2020 - "Taken together, narciclasine protected against lung injury via inhibition effect on excessive inflammation, oxidative stress and apoptosis, hence, narciclasine may be considered as an effective and novel agent for clinical therapeutic strategy of ALI Treatment."
12/01/2020 - "Narciclasine attenuates LPS-induced acute lung injury in neonatal rats through suppressing inflammation and oxidative stress."
12/01/2020 - "Narciclasine exhibits strong anti-inflammation activity and attenuates the reactive oxygen species (ROS) production. "
05/01/2015 - "Our study highlights HCE and its main alkaloid narciclasine as novel interesting approach for the treatment of inflammation-related disorders. "

12/01/2018 - "In this study, we explored the regulation mechanisms of narciclasine to autophagy and apoptosis processes in triple-negative breast cancer. "
12/01/2018 - "Narciclasine induces autophagy-dependent apoptosis in triple-negative breast cancer cells by regulating the AMPK-ULK1 axis."
12/01/2018 - "Effects of narciclasine on proliferation, apoptosis, and autophagy of HCC-1937 and MDA-MB-231 triple-negative breast cancer (TNBC) cells were assessed using transmission electronic microscopy, flow cytometry following staining with Annexin V-FITC and propidium iodide, RNA sequencing, real-time PCR, and Western blotting. "

12/01/2020 - "The present study aims to investigate the underlying mechanism related to the effect of narciclasine on the pathogenesis of neonatal acute lung injury (ALI). "
12/01/2020 - "Narciclasine attenuates LPS-induced acute lung injury in neonatal rats through suppressing inflammation and oxidative stress."