BE 2254

produces blockade of central receptors for norepinephrine; RN given refers to cpd without isomeric designation

Also Known As:

2-(beta-(4-hydroxyphenyl)ethylaminomethyl)tetralone; 2-HEAT; BE 2254, (+-)-isomer; BE-2254; IBE 2254; 1(2H)-naphthalenone, 3,4-dihydro-2-(((2-(4-hydroxyphenyl)ethyl)amino)methyl)-

Networked: 3 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Related Diseases

1.	Infarction (Infarctions) 10/01/1993 - "BE 2254 could not block ischemic preconditioning (3.9 +/- 1.1% infarction, P < .01 vs control value). " 10/01/1993 - "This protection observed with tyramine infusion was eliminated by alpha 1-receptor blockade with BE 2254 (36.8 +/- 2.6% infarction) but was unaffected by beta-blockade with propranolol (10.5 +/- 2.4% infarction). "
2.	Hyperthyroidism 12/01/1985 - "Scatchard analysis of specific [125I]BE 2254 binding showed that alpha-1 adrenergic receptor density was significantly decreased in the ventricles from hyperthyroid rats and increased in the ventricles of hypothyroid rats, but was unchanged in vas deferens, caudal artery and cerebral cortex. "
3.	Hypertension (High Blood Pressure) 03/01/1989 - "To determine whether adrenoceptor changes in genetic hypertension occur primary or secondary to blood pressure elevation, we measured cardiac and renal alpha 1- (by [125I]Be 2254 binding) and beta 1- and beta 2-adrenoceptors (by (-)-[125I]iodocyanopindolol binding) densities in various rat models of acquired hypertension (Dahl S rats on a high-sodium diet, 1-clip-1-kidney (1C-1K) renal hypertensive and DOCA-salt hypertensive rats) in comparison with genetically identical age-matched untreated rats. "

Related Drugs and Biologics

1.	Tyramine
2.	Propranolol (Inderal)
3.	Desoxycorticosterone Acetate (DOCA)
4.	Iodocyanopindolol
5.	alpha-1 Adrenergic Receptors (alpha 1 Adrenergic Receptor)
6.	Sodium
7.	Salts
8.	Adrenergic Receptors (Adrenergic Receptor)

Related Therapies and Procedures

1.	Surgical Instruments (Clip)