RA 642

has central hypertensive properties; structure

Also Known As:

(2,2'-(4,8-bis(diethylamino)pyrimido(5,4-d)pyrimidine-2,6-diyl)di(2-methoxyethyl)imino)diethanol; RA-642; 2,2'-((4,8-bis(diethylamino)pyrimido(5,4-d)pyrimidine-2,6-diyl)bis((2-methoxyethyl)imino))bisethanol

Networked: 8 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrimidines: 510
    - RA 642: 8

Related Diseases

1.	Abdominal Pain (Pain, Abdominal) 10/01/2021 - "The studies included 740 (RA), 307 (LN) and 104 (MG) patients The incidence of AEs was 127% in RA (642% of AEs potentially related to tacrolimus), 209% (378% potentially related) in LN and 298% (568% potentially related) in MG The incidence of ADRs was 84%, 98% and 202%, respectively Serious AEs were reported in 07%, 72% and 87%, respectively The most common AEs were abdominal pain (RA), pharyngitis (LN) and diarrhea (MG) Unexpected AEs occurred in 35% of patients with RA, 29% in LN and 87% in MG; no pattern of unexpected AEs was apparent Multivariable analysis demonstrated that patients with comorbidity had higher probability of experiencing an AE in RA and MG studies. "
2.	Pharyngitis (Sore Throat) 10/01/2021 - "The studies included 740 (RA), 307 (LN) and 104 (MG) patients The incidence of AEs was 127% in RA (642% of AEs potentially related to tacrolimus), 209% (378% potentially related) in LN and 298% (568% potentially related) in MG The incidence of ADRs was 84%, 98% and 202%, respectively Serious AEs were reported in 07%, 72% and 87%, respectively The most common AEs were abdominal pain (RA), pharyngitis (LN) and diarrhea (MG) Unexpected AEs occurred in 35% of patients with RA, 29% in LN and 87% in MG; no pattern of unexpected AEs was apparent Multivariable analysis demonstrated that patients with comorbidity had higher probability of experiencing an AE in RA and MG studies. "
3.	Diarrhea 10/01/2021 - "The studies included 740 (RA), 307 (LN) and 104 (MG) patients The incidence of AEs was 127% in RA (642% of AEs potentially related to tacrolimus), 209% (378% potentially related) in LN and 298% (568% potentially related) in MG The incidence of ADRs was 84%, 98% and 202%, respectively Serious AEs were reported in 07%, 72% and 87%, respectively The most common AEs were abdominal pain (RA), pharyngitis (LN) and diarrhea (MG) Unexpected AEs occurred in 35% of patients with RA, 29% in LN and 87% in MG; no pattern of unexpected AEs was apparent Multivariable analysis demonstrated that patients with comorbidity had higher probability of experiencing an AE in RA and MG studies. "
4.	Bradycardia 01/01/1976 - "1 mg/kg RA 642 i.v. decreased the reflex bradycardia elicited by the i.v. injection of angiotensin in dogs pretreated with a beta-adrenoceptor blocking drug to study the vagal effector reactions of the baroreceptor reflex, and treated with clonidine to facilitate the reflex. "
5.	Shock 05/01/1986 - "The anti-shock actions of RA-642 were studied in traumatic shock in rats. " 11/01/1987 - "[Effects of 2,2'-[(4,8-bis(diethylamino)-pyrimido[5,4-d]pyrimidine-2,6-diyl) di-(2-methoxyethyl)imino]diethanol (RA 642) on experimental scald shock]." 05/01/1986 - "Anti-shock actions of the pyrimido-pyrimidine derivative, RA-642."

Related Drugs and Biologics

1.	Tacrolimus (Prograf)
2.	Adrenergic Receptors (Adrenergic Receptor)
3.	Clonidine (ST 155)
4.	Angiotensins
5.	pyrimidine
6.	Mopidamol
7.	Dipyridamole (Persantine)
8.	Retinaldehyde (Retinal)