terodiline (TD 758)

lipophilic drug with oral bioavailability of 80%; formerly used as antianginal drug; may be used to treat motor urge incontinence in women; withdrawn by manufacturer pending further safety evaluation, Vet Res 1991;129(14):319

Also Known As:

Networked: 76 relevant articles (9 outcomes, 12 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Campeau, Lysanne: 1 article (08/2011)
2.	Andersson, Karl-Erik: 1 article (08/2011)
3.	Olshansky, Brian: 1 article (08/2011)
4.	Limberis, James T: 1 article (11/2006)
5.	Gintant, Gary A: 1 article (11/2006)
6.	Martin, Ruth L: 1 article (11/2006)
7.	Cox, Bryan F: 1 article (11/2006)
8.	Su, Zhi: 1 article (11/2006)
9.	Palmatier, Jason D: 1 article (11/2006)
10.	Cowart, Marlon D: 1 article (11/2006)

Related Diseases

1.	Urinary Incontinence 08/01/1999 - "1. Terodiline, an anticholinergic/antispasmodic drug effective in the treatment of urinary incontinence, is presently restricted due to adverse side effects on cardiac function. " 08/01/1992 - "The results obtained from this study suggest that terodiline hydrochloride may be greatly useful for the patients with urinary frequency and urinary incontinence. " 08/01/1992 - "[Clinical study of terodiline hydrochloride for the treatment of urinary frequency and urinary incontinence, and its cardiovascular adverse effects]." 07/01/1995 - "Concentration dependent cardiotoxicity of terodiline in patients treated for urinary incontinence." 09/01/1993 - "Effects of terodiline on urinary incontinence among older non-institutionalized women. "
2.	Cystitis 01/01/1988 - "We evaluated the efficacy of terodiline hydrochloride (TD-758) in 23 patients with psychosomatic bladder, chronic prostatitis and chronic cystitis. " 04/01/1991 - "A clinical trial with the collaboration of 15 department of urology was performed to determine the usefulness of terodiline hydrochloride in 99 patients whose chief complaints were of pollakisuria or incontinence due to neurogenic bladder, psychogenic disease or chronic cystitis. " 04/01/1988 - "These results indicate that terodiline HCl is useful for the treatment of urinary symptoms in patients with psychogenic diseases, chronic prostatitis or chronic cystitis." 04/01/1988 - "A double blind clinical trial was performed as a multicenter study to determine the usefulness of terodiline hydrochloride (HCl), an anticholinergic and calcium antagonistic agent, for urinary frequency or sense of residual urine in patients with psychogenic diseases, chronic prostatitis or chronic cystitis. "
3.	Prostatitis 01/01/1988 - "We evaluated the efficacy of terodiline hydrochloride (TD-758) in 23 patients with psychosomatic bladder, chronic prostatitis and chronic cystitis. " 04/01/1988 - "These results indicate that terodiline HCl is useful for the treatment of urinary symptoms in patients with psychogenic diseases, chronic prostatitis or chronic cystitis." 04/01/1988 - "A double blind clinical trial was performed as a multicenter study to determine the usefulness of terodiline hydrochloride (HCl), an anticholinergic and calcium antagonistic agent, for urinary frequency or sense of residual urine in patients with psychogenic diseases, chronic prostatitis or chronic cystitis. "
4.	Urge Urinary Incontinence (Urge Incontinence) 09/01/1993 - "Terodiline is highly effective in reducing incontinence in older, noninstitutionalized women with urge incontinence. " 09/01/1994 - "Randomized double-blind trial of terodiline in the treatment of urge incontinence in women." 11/15/1985 - "The effects of terodiline were evaluated in 24 women with genuine motor urge incontinence: Twelve patients participated in a double-blind crossover study and 12 in a subsequent long-term study. " 01/01/1984 - "In order to evaluate safety and clinical benefits of terodiline during long-term therapy in women with urgency/urge incontinence, a 6-month study has been performed. " 09/01/1994 - "After a 2-week run-in period, 93 women with urinary frequency and urge incontinence were randomized to either placebo or terodiline, 25 mg twice daily, in a double-blind study for 4 weeks. "
5.	Abnormal Reflex (Hyperreflexia) 06/01/1993 - "The current study characterizes the ability of terodiline to inhibit an experimental form of hyperreflexia and compares the efficacy and potency of terodiline and other agents on hyperreflexia and evoked contractions. " 06/01/1989 - "Terodiline is an alternative drug in the treatment of detrusor hyperreflexia. " 10/01/1987 - "It is concluded that terodiline is a useful alternative in treatment of patients with detrusor hyperreflexia." 10/01/1987 - "In 25 neurological patients with detrusor hyperreflexia terodiline reduced the number of total micturitions during daytime. " 12/01/1992 - "Intravesical administration of terodiline may offer an alternative treatment in selected patients with detrusor hyperreflexia."

Related Drugs and Biologics

1.	Calcium
2.	oxybutynin (Tavor)
3.	NS 21 (temiverine)
4.	Flavoxate (Urispas)
5.	RCC 36
6.	tolterodine (Detrol)
7.	terodiline (TD 758)
8.	Cytochrome P-450 CYP2D6 (CYP2D6)
9.	Bethanechol (Duvoid)
10.	Cholinergic Agents (Cholinergics)

Related Therapies and Procedures

1.	Intravesical Administration
2.	Complementary Therapies (Alternative Medicine)
3.	Aftercare (After-Treatment)