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3-deazaguanosine
structure
Also Known As:
7-(beta-D-ribofuranosyl-3-deazaguanine); 7-ribosyl-3-deazaguanine; 6-amino-beta-D-ribofuranosylimidazo(4,5-c)pyridin- 4(5H)-one
Networked:
4
relevant articles (
0
outcomes,
1
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
Fused-Ring Heterocyclic Compounds
2-Ring Heterocyclic Compounds
Purines: 651
Purine Nucleosides: 360
Guanosine: 1156
3-deazaguanosine: 4
Nucleic Acids, Nucleotides, and Nucleosides: 1
Nucleosides: 6847
Purine Nucleosides: 360
Guanosine: 1156
3-deazaguanosine: 4
Ribonucleosides: 49
Guanosine: 1156
3-deazaguanosine: 4
Related Diseases
1.
Neoplasms (Cancer)
01/01/1985 - "
Studies on the mechanism of cytotoxicity of 3-deazaguanosine in human cancer cells.
"
04/01/1987 - "
Synergistic antiproliferative effects of a combination of 3-deazaguanosine and 2-beta-D-ribofuranosylthiazole-4-carboxamide, a potent inhibitor of inosine monophosphate dehydrogenase, was observed in human tumor cells.
"
2.
Leukemia
01/01/1984 - "
Effects of 3-deazaguanosine and 3-deazaguanine on the growth and maturation of the human promyelocytic leukemia cell line, HL-60.
"
3.
Infections
10/01/1994 - "
Of these, ribavirin, ribamidine, ribavirin 2',3',5'-triacetate, tiazofurin, tiazofurin-5'-monophosphate, tiazofurin-2',3',5'-triacetate, selenazofurin, pyrazofurin, 3-deazaguanine, and 3-deazaguanosine were considered significantly inhibitory, acting against the infection by a direct antiviral (non-immunomodulatory) fashion.
"
Related Drugs and Biologics
1.
tiazofurin
2.
3-deazaguanine
3.
Ribavirin (Virazole)
4.
Oxidoreductases (Dehydrogenase)
5.
Inosine Monophosphate (IMP)
6.
Antiviral Agents (Antivirals)
7.
selenazofurin
8.
ribavirin 2',3',5'-triacetate
9.
taribavirin (viramidine)
10.
pyrazofurin