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3-deazaguanine

structure

Also Known As:

6-aminoimidazo(4,5-c)pyridin-4(5H)-one

Networked: 8 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Purines: 651
      - Purinones: 2
        Hypoxanthines: 1
        Guanine: 1793
        3-deazaguanine: 8

Experts

1.	Clyde, Nathan: 1 article (01/2017)
2.	Day, Craig W: 1 article (01/2017)
3.	Evans, W Joseph: 1 article (01/2017)
4.	Hurst, Brett L: 1 article (01/2017)
5.	Jung, Kie-Hoon: 1 article (01/2017)
6.	Peterson, Christopher: 1 article (01/2017)
7.	Smee, Donald F: 1 article (01/2017)
8.	Wright, Sean: 1 article (01/2017)

Related Diseases

1.	Neoplasms (Cancer) 01/01/1988 - "3-Deazaguanine (3-DG), a purine analogue, has unusual antitumor activity against experimental mammary tumor models and a number of other solid tumors. " 10/01/1982 - "3-Deazaguanine (3-DG) is a new purine antagonist that is active against slow- and rapid-growing solid experimental tumors, especially those that are models for human breast carcinomas. " 11/01/1990 - "3-Deazaguanine (Dezaguanine), a purine antimetabolite, was evaluated in a phase I trial in 42 patients with advanced solid tumors. " 10/01/1986 - "3-Deazaguanine, a tumor-inhibitory purine antimetabolite, is cytotoxic to L1210 leukemic cells in culture. "
2.	Sarcoma 180 08/01/1979 - "In contrast to 3-deazaguanine and its ribosyl derivative, the nucleosides described in this paper were found to be inactive against Sarcoma 180 in mice at 100 mg/kg."
3.	Leukemia 01/01/1984 - "Effects of 3-deazaguanosine and 3-deazaguanine on the growth and maturation of the human promyelocytic leukemia cell line, HL-60."
4.	Infections 10/01/1994 - "Of these, ribavirin, ribamidine, ribavirin 2',3',5'-triacetate, tiazofurin, tiazofurin-5'-monophosphate, tiazofurin-2',3',5'-triacetate, selenazofurin, pyrazofurin, 3-deazaguanine, and 3-deazaguanosine were considered significantly inhibitory, acting against the infection by a direct antiviral (non-immunomodulatory) fashion. "
5.	Dengue (Dengue Fever) 01/01/2017 - "Viruses were chikungunya, dengue type 2, and Junin, which generally cause 100, 80-90, and 50% maximal cytopathic effect (CPE), respectively, in Vero or Vero 76 cells Compounds evaluated were 6-azauridine, BCX-4430, 3-deazaguanine, EICAR, favipiravir, infergen, mycophenolic acid (MPA), ribavirin, and tiazofurin. "

Related Drugs and Biologics

1.	purine
2.	Antimetabolites
3.	Ribavirin (Virazole)
4.	tiazofurin
5.	3-deazaguanosine
6.	Nucleosides
7.	Mycophenolic Acid (Cellcept)
8.	Azauridine (6 Azauridine)
9.	Antiviral Agents (Antivirals)
10.	galidesivir

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)