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zinc pyrithione (ZPT)

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dimer of two pyrithione molecules bound by zinc; ingredient of commercial anti-dandruff shampoos; Do not confuse zinc pyrithione with Raman spectrum probe dye known as zincon

Also Known As:

ZPT; ZNP; pyrithione zinc; Sebulon; Dan-Gard; Faulding brand of zinc pyrithione; Head & Shoulders brand of zinc pyrithione; Hermal brand of zinc pyrithione; Procter & Gamble brand of zinc pyrithione; Stiefel brand 1 of zinc pyrithione; Stiefel brand 2 of zinc pyrithione; Westwood Squibb brand of zinc pyrithione; Zincon (zinc pyrithione); bis(N-oxopyridine-2-thionato)zinc (II); de-squaman; zinc pyridinethione; zincpolyanemine; (T-4)-bis(1-hydroxy-2(1H)- pyridinethionato-O,S)zinc

Networked: 54 relevant articles (9 outcomes, 8 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Bodiga, Sreedhar: 2 articles (12/2015 - 07/2011)
2.	Bodiga, Vijaya Lakshmi: 2 articles (12/2015 - 07/2011)
3.	Ahn, Kyu Joong: 2 articles (12/2014 - 03/2009)
4.	Lee, Yang Won: 2 articles (12/2014 - 03/2009)
5.	Choe, Yong Beom: 2 articles (12/2014 - 03/2009)
6.	Thokala, Sandhya: 1 article (12/2015)
7.	Vemuri, Praveen Kumar: 1 article (12/2015)
8.	Kimball, Alexa Boer: 1 article (11/2015)
9.	Danesh, Melissa J: 1 article (11/2015)
10.	Datti, Alessandro: 1 article (10/2015)

Related Diseases

1.	Psoriasis (Pustulosis Palmaris et Plantaris) 03/01/2005 - "Zinc pyrithione is a shampoo ingredient that has been shown to be safe and effective for dandruff and scalp psoriasis. " 03/01/1997 - "Topical zinc pyrithione appears to be a safe and effective treatment for psoriasis." 01/01/2011 - "To test the efficacy of a topical formulation of zinc pyrithione in an emollient base compared with an emollient alone in the treatment of psoriasis. " 01/01/2011 - "A topical formulation of zinc pyrithione can be used to treat localized psoriasis." 01/01/2011 - "Treatment of localized psoriasis with a topical formulation of zinc pyrithione."
2.	Seborrheic Dermatitis 03/01/2009 - "Previous studies have shown that topical steroid and shampoo containing zinc pyrithione provide clinical benefits for treatment of scalp seborrheic dermatitis. " 01/01/2009 - "Does tachyphylaxis occur in long-term management of scalp seborrheic dermatitis with pyrithione zinc-based treatments?" 11/01/2002 - "It is concluded that after a 4-week treatment, KET 2% shampoo was significantly superior to ZPT 1% shampoo in the treatment of subjects with severe dandruff or seborrheic dermatitis of the scalp. " 11/01/2002 - "We compared the efficacy and safety of KET 2% and ZPT 1% in shampoo formulations for the alleviation of severe dandruff and seborrheic dermatitis. " 12/01/2006 - "In conclusion, this study demonstrates the in vitro inhibitory and fungicidal efficacy of the ciclopirox olamine/zinc pyrithione association against Malassezia species and underscores its potential interest in the treatment of seborrheic dermatitis."
3.	Tinea Versicolor 06/01/1980 - "The effect of zinc pyrithione 1 percent, incorporated in a shampoo, has been tested in an open trial of twenty patients with tinea versicolor. " 06/01/1980 - "An open trial of the effect of a zinc pyrithione shampoo in tinea versicolor." 04/01/1983 - "A zinc pyrithione shampoo was compared with its shampoo base in the treatment of tinea versicolor. " 04/01/1983 - "Double-blind comparison of a zinc pyrithione shampoo and its shampoo base in the treatment of tinea versicolor." 06/01/2015 - "zinc pyrithione, selenium disulfide, and salicylic acid, are also effective in pityriasis versicolor. "
4.	Anoxia (Hypoxia) 12/01/2015 - "Zinc pyrithione effectively suppressed the caspase activation, decreased the proteolytic cleavage of ErbB2, enhanced the phosphorylation and activation of ErbB1-ErbB2 complexes and improved the cell survival after hypoxia/reoxygenation. " 07/01/2011 - "Because oxidative stress has been proposed to contribute to myocardial reperfusion injury, we tested whether ZPT can reduce the production of reactive oxygen species during reoxygenation in cultured neonatal rat cardiac myocytes and evaluated the role of NADPH oxidase in hypoxia/reoxygenation (H/R) injury. "
5.	Erythema 12/01/2014 - "Furthermore, it was found to provide a more rapid response than the 1% zinc-pyrithione shampoo for mild erythema lesions and was associated with greater user satisfaction compared with the 2% ketoconazole shampoo. " 06/01/2014 - "A new shampoo containing beta-glycyrrhetinic acid (18βGA) in addition to cyclopiroxolamine (CPO) and zinc pyrithione (ZP) was tested in 67 subjects suffering from SD with moderate to severe erythema and itching in a biphasic study. "

Related Drugs and Biologics

1.	ciclopirox (Loprox)
2.	selenium disulfide (Head & Shoulders)
3.	Salicylic Acid (2 Hydroxybenzoic Acid)
4.	Tacrolimus (Prograf)
5.	Clobetasol (Clobetasol Propionate)
6.	Betamethasone (Celestone)
7.	Ketoconazole (Nizoral)
8.	zinc protoporphyrin
9.	Polytetrafluoroethylene (Teflon)
10.	Glycyrrhetinic Acid (Po 12)

Related Therapies and Procedures

1.	Heterologous Transplantation (Xenotransplantation)