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R 28935
RN given refers to (R*,S*)-isomer; structure
Also Known As:
R 28935, (R*,R*)-isomer; R 29814; R-28935; R-29814; erythro-1-(1-(2-(1,4-benzodioxan-2-yl)-2hydroxyethyl)-4-piperidyl)-2-benzimidazolinone
Networked:
3
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Dioxanes
R 28935: 3
Fused-Ring Heterocyclic Compounds
2-Ring Heterocyclic Compounds
Benzimidazoles: 245
R 28935: 3
Related Diseases
1.
Hypotension (Low Blood Pressure)
02/01/1982 - "
Inhibition of R 28935- and R 29814-induced hypotension by prazosin in anaesthetized normotensive rats.
"
02/01/1982 - "
It is concluded that neither alpha 1- and alpha 2- nor opiate-receptors are involved as the primary targets for R 28935 and its congeneric drugs to induce hypotension.
"
2.
Orthostatic Hypotension (Postural Hypotension)
05/01/1975 - "
Significant postural hypotension during tilting, is induced by guanethidine and mecamylamine but not by R 28935.
"
3.
Renal Hypertension
05/01/1975 - "
In anaesthetized beagles with renal hypertension, the lowering of the blood pressure by R 28935, (0.02-0.64 mg/kg i.v.) is associated with a considerable decrease in the total peripheral vascular resistance, whereas the myocardial function is not affected.
"
05/01/1975 - "
Erythro-1-(1-[2-(1,4-benzodioxan-2-yl)-2-OH-ET]-4-piperidyl)-2-benzimidazolinone (R 28935), provokes marked antihypertensive effects lasting several hours in conscious SHR (0.63 to 40 mg/kg i.p.) and beagles with renal hypertension (1.25 mg/kg p.o.).
"
Related Drugs and Biologics
1.
Opioid Receptors (Opioid Receptor)
2.
Prazosin (Minipress)
3.
Mecamylamine
4.
Guanethidine
5.
Antihypertensive Agents (Antihypertensives)
6.
hydroxide ion