lysin

mucopolysaccharide-protein complex isolated from egg membrane of sea snail, Tegula pfeifferi; exerts stoichiometric lytic activity on the membrane; also isolated from sperm of marine invertebrate Megathura crenulata which lyse the egg-membrane of the same species; may have enzymatic activity; composed of 134 amino acids; amino acid sequence known; from acrosome granule of abalone sperm, MW 16,000; do not confuse with STAPH ALPHA-LYSIN

Also Known As:

Networked: 103 relevant articles (5 outcomes, 7 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Fischetti, Vincent A: 7 articles (12/2015 - 02/2007)
2.	Euler, Chad W: 4 articles (12/2015 - 06/2013)
3.	Schuch, Raymond: 3 articles (04/2015 - 02/2007)
4.	Lood, Rolf: 2 articles (04/2015 - 06/2014)
5.	Pelzek, Adam J: 2 articles (04/2015 - 02/2007)
6.	Raz, Assaf: 2 articles (06/2014 - 05/2014)
7.	Liu, Bing: 2 articles (02/2013 - 08/2012)
8.	Qi, Kangbiao: 2 articles (02/2013 - 08/2012)
9.	Wang, Hong-Bin: 2 articles (02/2013 - 08/2012)
10.	Liu, Jun: 2 articles (02/2013 - 08/2012)

Related Diseases

1.	Infection 01/01/2015 - "This study demonstrates the success of the screening method resulting in a powerful lysin with potential for treating most streptococcal associated infections. " 05/01/1979 - "A study of the time course of the appearance of the lysin during infection showed that it appeared and increased in cells infected with wild-type virus and in suppressor cells infected with a mutant of class 511, but it did not increase in nonsuppressor cells infected with the class 511 mutant. " 12/01/2015 - "Using a Novel Lysin To Help Control Clostridium difficile Infections." 06/01/2013 - "Novel bacteriophage lysin with broad lytic activity protects against mixed infection by Streptococcus pyogenes and methicillin-resistant Staphylococcus aureus." 01/01/2011 - "The phage lysin LysGH15 might be an alternative treatment strategy for infections caused by MRSA."
2.	Herpes Zoster 02/01/1995 - "In a series of four prospective experiments, our aims were to [1] test the efficacy of the antihatching model and assisted hatching; [2] exam the influence of initial in vivo developmental stage and late serum supplementation on hatching inhibition; [3] discount the role of zona hardness and physical expansion directly affecting hatching; and [4] provide evidence that the trophectoderm is directly responsible for secreting a zona lysin. " 11/01/1985 - "An additional role as a scaffold for putative zona lysin material remains controversial. " 11/01/1978 - "The validity of the general belief that a lysin in necessary for zona penetration is considered briefly in relation to the mode of penetration and structural organization of the mammalian sperm head." 08/01/1978 - "Sperm form a characteristic penetration slit little wider than the sperm head itself and this has long suggested that any zona lysin is attached to the sperm surface after an acrosome reaction. " 01/01/2011 - "Thus, the sperm borne 26S proteasome is a candidate zona lysin in mammals. "
3.	Bacteremia 05/01/2014 - "Combination therapy with lysin CF-301 and antibiotic is superior to antibiotic alone for treating methicillin-resistant Staphylococcus aureus-induced murine bacteremia." 04/01/2015 - "baumannii bacteremia and as such represents the first highly active therapeutic lysin specific for Gram-negative organisms in an array of native lysins found in Acinetobacter phage. " 04/01/2015 - "Novel phage lysin capable of killing the multidrug-resistant gram-negative bacterium Acinetobacter baumannii in a mouse bacteremia model." 12/01/2013 - "In vitro characterization of PlySK1249, a novel phage lysin, and assessment of its antibacterial activity in a mouse model of Streptococcus agalactiae bacteremia." 01/01/2011 - "Bacteremia in unprotected mice reached colony counts of about 10(7) CFU/ml within 3.5 h after challenge, whereas the mean colony count in lysin-protected mice was less than 10(4) CFU/ml (and ultimately became undetectable). "
4.	Neuroblastoma 05/01/2000 - "To elucidate the role of adhesion molecules during neuronal cell differentiation, we have analysed the adhesion of neuroblastoma cells on poly-D-lysin-precoated plates under RA influence. " 02/01/2008 - "We tested the hypothesis that oral application of L-lysine and ascorbic acid (Lysin C Drink) in combination with epigallocatechin-gallate (EGCG) and amino-acids (Epican forte) is effective in a preclinical model of neuroblastoma. "
5.	Endocarditis 11/01/2005 - "Therapeutic effects of bacteriophage Cpl-1 lysin against Streptococcus pneumoniae endocarditis in rats." 01/01/2010 - "Once on the bacterial surface, lysin can bind fibrinogen directly, which appears to be an important interaction for the pathogenesis of endocarditis." 01/01/2010 - "When tested in a co-infection model of endocarditis, loss of lysin expression resulted in a significant reduction in virulence, as measured by achievable bacterial densities (CFU/g) within vegetations, kidneys, and spleens. "

Related Drugs and Biologics

1.	N-Acetylmuramoyl-L-alanine Amidase (Autolysin)
2.	Amino Acids
3.	Lysine (L-Lysine)
4.	Carbon Monoxide
5.	Ascorbic Acid (Vitamin C)
6.	keratinocyte CD44
7.	epigallocatechin gallate (epigallocatechin-3-gallate)
8.	Vasopressins (Vasopressin)
9.	Methionine (L-Methionine)
10.	Insulin (Novolin)

Related Therapies and Procedures

1.	Minor Surgical Procedures (Minor Surgery)
2.	Adrenalectomy
3.	Total Parenteral Nutrition
4.	Subcutaneous Injections
5.	General Anesthesia