nitrosoproline

RN given refers to 1-nitroso-L-proline

Also Known As:

N-nitroso-L-proline; N-nitrosoproline; nitrosoproline, (D)-isomer; nitrosoproline, (D,L)-isomer; nitrosoproline, (cis)-isomer; nitrosoproline, (trans)-isomer; nitrosoproline, 14C-labeled cpd

Networked: 28 relevant articles (0 outcomes, 7 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Nitroso Compounds: 446
  - Nitrosamines: 1539
    - nitrosoproline: 28

Experts

1.	Bartsch, Helmut: 1 article (07/2002)

Related Diseases

1.	Carcinogenesis 11/01/1993 - "The hypothesis that intragastric synthesis of N-nitroso compounds (NOC) in early life could play a role in gastric carcinogenesis was tested by applying the N-nitrosoproline (NPRO) test to about 50 children living in high- and low-risk areas for stomach cancer in Costa Rica. " 02/01/1987 - "Urinary N-nitrosoproline excretion: a further evaluation of the nitrosamine hypothesis of gastric carcinogenesis in precancerous conditions." 04/01/1994 - "The review covers the older literature on ASC inhibition of carcinogenesis by nitrite administered with amines or amides and more recent studies on ASC inhibition of nitrosation by bacteria, nitrogen oxides, and activated macrophages; the role of oxygen in ASC inhibition of gastric nitrosation; ASC inhibition of N-nitrosoproline formation in subjects from areas with high incidences of certain cancers; dose and temporal relationships between ASC and in vivo nitrosation in humans; the role of substances other than ASC in the inhibition of nitrosation by vegetables and fruits; and the active secretion of ASC into the human stomach." 06/29/1995 - "The principal subjects covered include nitrite-derived alkylating agents that are not NOC, reasons for the wide tissue specificity of carcinogenesis by NOC, the acute toxicity of nitrosamines in humans, mechanisms of in vivo formation of NOC by chemical and bacterial nitrosation in the stomach and via nitric oxide (NO) formation during inflammation, studies on nitrite esters, use of the nitrosoproline test to follow human gastric nitrosation, correlations of nitrate in food and water with in vivo nitrosation and the inhibition of gastric nitrosation by vitamin C and polyphenols. "
2.	Neoplasms (Cancer) 01/01/1991 - "The N-nitrosoproline (NPRO) test has been used in studies in which populations at high risk of cancer have been compared with equivalent populations at lower risk, to examine whether the geographical variation in cancer risk correlates with propensity for endogenous nitrosation, as assessed by the NPRO test. " 01/01/1991 - "The N-nitrosoproline test as a measure of cancer risk in geographical comparison studies: results from Italy and an overall comparison." 01/01/1987 - "Determination of N-nitrosamines in gastric juice and urine and a comparison of endogenous formation of N-nitrosoproline and its inhibition in subjects from high- and low-risk areas for oesophageal cancer." 07/09/1993 - "Oesophageal cancer mortality rates were positively and significantly associated with (i) urinary levels of excreted N-nitrosoproline (NPRO) (after proline and ascorbic acid loading or proline loading only), (ii) N-nitrososarcosine levels, and (iii) nitrosation potential (the decrease in the amount of urinary NPRO after adding ascorbic acid to the proline load). " 04/01/1994 - "The review covers the older literature on ASC inhibition of carcinogenesis by nitrite administered with amines or amides and more recent studies on ASC inhibition of nitrosation by bacteria, nitrogen oxides, and activated macrophages; the role of oxygen in ASC inhibition of gastric nitrosation; ASC inhibition of N-nitrosoproline formation in subjects from areas with high incidences of certain cancers; dose and temporal relationships between ASC and in vivo nitrosation in humans; the role of substances other than ASC in the inhibition of nitrosation by vegetables and fruits; and the active secretion of ASC into the human stomach."
3.	Stomach Neoplasms (Stomach Cancer) 01/01/1991 - "Recent metabolic studies in high- and low-risk areas for stomach cancer or in groups with precursor lesions, with the N-nitrosoproline test as a marker for endogenous nitrosation, revealed inconsistent results. " 11/01/1993 - "In vivo nitrosoproline formation and other risk factors in Costa Rican children from high- and low-risk areas for gastric cancer." 08/01/1989 - "Use of a modified N-nitrosoproline test to show intragastric nitrosation in patients at risk of gastric cancer." 07/01/1993 - "Effects of fruit juices, processed vegetable juice, orange peel and green tea on endogenous formation of N-nitrosoproline in subjects from a high-risk area for gastric cancer in Moping County, China." 03/12/1992 - "Nitrate and N-nitrosoproline excretion in two Italian regions with contrasting rates of gastric cancer: the role of nitrate and other factors in endogenous nitrosation."
4.	Esophageal Neoplasms (Esophageal Cancer) 07/01/2002 - "By applying the nitrosoproline (NPRO) test in ecological studies on esophageal cancer causation in China some support was obtained for the involvement of N-nitroso compounds. " 12/15/1997 - "Effect of esophageal cancer- and stomach cancer-preventing vinegar on N-nitrosoproline formation in the human body." 03/01/1986 - "Urinary excretion of N-nitrosamino acids and nitrate by inhabitants of high- and low-risk areas for esophageal cancer in Northern China: endogenous formation of nitrosoproline and its inhibition by vitamin C."
5.	Precancerous Conditions 01/01/1987 - "The N-nitrosoproline (NPRO) test was used to study whether subjects with precancerous conditions of the stomach have an elevated potential for endogenous nitrosation. " 02/01/1987 - "Urinary N-nitrosoproline excretion: a further evaluation of the nitrosamine hypothesis of gastric carcinogenesis in precancerous conditions."

Related Drugs and Biologics

1.	Nitrites
2.	Nitrates
3.	Nitrosamines
4.	Ascorbic Acid (Vitamin C)
5.	Nitroso Compounds
6.	Polyphenols
7.	Oxygen (Dioxygen)
8.	Nitrogen Oxides
9.	Nitric Oxide (Nitrogen Monoxide)
10.	Esters

Related Therapies and Procedures

1.	Steam Bath (Sauna)
2.	Gastroscopes