10-formyltetrahydropteroylglutamic acid

Also Known As:

10-FTHF; 10-formyltetrahydrofolate

Networked: 15 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Pteridines: 147
      - Pterins: 160
        Folic Acid: 19425
        Tetrahydrofolates: 8
        Formyltetrahydrofolates
        Leucovorin: 5743
        10-formyltetrahydropteroylglutamic acid: 15
Enzymes and Coenzymes: 1
- Coenzymes: 558
  - Tetrahydrofolates: 8
    - Formyltetrahydrofolates
      - Leucovorin: 5743
        10-formyltetrahydropteroylglutamic acid: 15

Experts

1.	Lianeri, Margarita: 2 articles (01/2010 - 06/2007)
2.	Golczak, Marcin: 1 article (10/2022)
3.	Krupenko, Natalia I: 1 article (10/2022)
4.	Krupenko, Sergey A: 1 article (10/2022)
5.	Sereda, Valentin: 1 article (10/2022)
6.	Tsybovsky, Yaroslav: 1 article (10/2022)
7.	Chauhan, Vikas Singh: 1 article (05/2022)
8.	Divya, Peethambaran: 1 article (05/2022)
9.	Pathikkal, Ajana: 1 article (05/2022)
10.	Puthusseri, Bijesh: 1 article (05/2022)

Related Diseases

1.	Inflammation (Inflammations) 05/01/2022 - "5-methyltetrahydrofolate and 10-formyltetrahydrofolate, were evaluated for their antioxidant and antiinflammatory potential against high glucose (50 mM)-mediated oxidative stress and inflammation in BEAS-2B cells, an immortalised bronchial epithelial cell line. " 05/01/2022 - "Supplementation of the active folate derivatives 5-methyltetrahydrofolate and 10-formyltetrahydrofolate resulted in significantly higher protection over the folic acid from high glucose-induced oxidative stress and inflammation. " 05/01/2022 - "Folate derivatives, 5-methyltetrahydrofolate and 10-formyltetrahydrofolate, protect BEAS-2B cells from high glucose-induced oxidative stress and inflammation."
2.	Hepatocellular Carcinoma (Hepatoma) 01/01/1991 - "The concentrations of 10-formyltetrahydrofolate and 10-formyldihydrofolate were measured in dividing hepatoma cells by a novel enzymatic assay and were found to be 5 microM and undetectable, respectively. " 01/01/2023 - "We focused on aldehyde dehydrogenase 1 family member L1 (ALDH1L1), which metabolizes 10-fTHF to tetrahydrofolate and whose expression is often attenuated in hepatocellular carcinoma (HCC). " 11/01/1992 - "Depletion of 5,10-methylenetetrahydrofolate and 10-formyltetrahydrofolate by methotrexate in cultured hepatoma cells."
3.	Schizophrenia (Dementia Praecox) 05/01/1977 - "faecalis values in the serum in normal subjects and in patients with various disorders showed that levels of 10-formyltetrahydrofolate are raised in coeliac disease, leukaemia, rheumatoid arthritis, and schizophrenia. " 06/01/2007 - "Therefore, we examined the prevalence of 1958G>A polymorphism of MTHFD1 gene, encoding trifunctional folate enzyme 5,10-methylenetetrahydrofolate dehydrogenase, 5,10-methenyltetrahydrofolate cyclohydrolase and 10-formyltetrahydrofolate synthetase (MTHFD1), and 2756A>G variant of methionine synthase (MTR) gene in patients with BD (n=200), schizophrenia (n=200) and in controls (n=300). "
4.	Neoplasms (Cancer) 01/15/2009 - "The GART activity of GART requires 10-formyltetrahydrofolate and has been a target for anti-cancer drugs. " 10/01/2022 - "Putative tumor suppressor ALDH1L1, the product of natural fusion of three unrelated genes, regulates folate metabolism by catalyzing NADP+-dependent conversion of 10-formyltetrahydrofolate to tetrahydrofolate and CO2. "
5.	Neural Tube Defects (Exencephaly) 01/01/2018 - "Homozygous deletion of the 1C pathway gene Mthfd1l encoding methylenetetrahydrofolate dehydrogenase (NADP+-dependent) 1-like, which catalyzes mitochondrial formate production from 10-formyltetrahydrofolate, results in 100% penetrant embryonic neural tube defects (NTDs), underscoring the central role of mitochondrially derived formate in embryonic development and providing a mechanistic link between folate and NTDs. "

Related Drugs and Biologics

1.	5-methyltetrahydrofolate
2.	Glucose (Dextrose)
3.	Antioxidants
4.	Ligases (Synthetase)
5.	Folic Acid (Vitamin M)
6.	5,6,7,8-tetrahydrofolic acid (tetrahydrofolate)
7.	5,10-methylenetetrahydrofolic acid
8.	Methenyltetrahydrofolate Cyclohydrolase
9.	5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase (Methyltetrahydrofolate Homocysteine Methyltransferase)
10.	Oxidoreductases (Dehydrogenase)

Related Therapies and Procedures

1.	Intravenous Injections