desacetylcephalothin

RN given refers to (6R-trans)-isomer; structure

Also Known As:

deacetylcephalothin; desacetylcephalothin, (6R-(6alpha,7beta))-isomer; desacetylcephalothin, monopotassium salt, (6R-trans)-isomer; desacetylcephalothin, monosodium salt, (6R-trans)-isomer

Networked: 1 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Related Diseases

1.	Pneumococcal Meningitis (Streptococcus pneumoniae Meningitis) 03/01/1980 - "A study of cephalothin and desacetylcephalothin in cerebrospinal fluid in therapy for experimental pneumococcal meningitis." 03/01/1980 - "One explanation for the failure of cephalothin to cure patients with bacterial meningitis is that desacetylcephalothin, as in vivo metabolite that has less antibacterial activity than the parent drug, penetrates more efficiently into cerebrospinal fluid (CSF); In experimental pneumococcal meningitis in rabbits, the peak levels of cephalothin and desacetylcephalothin in CSF after an intramuscular injection of 250 mg of cephalothin/kg were, respectively, 1.43 +/- 4.9 microgram/ml (2.8% of peak serum level) and 1.69 +/- 0.57 microgram/ml (2.2% of peak serum level). "
2.	Bacterial Meningitis 03/01/1980 - "One explanation for the failure of cephalothin to cure patients with bacterial meningitis is that desacetylcephalothin, as in vivo metabolite that has less antibacterial activity than the parent drug, penetrates more efficiently into cerebrospinal fluid (CSF); In experimental pneumococcal meningitis in rabbits, the peak levels of cephalothin and desacetylcephalothin in CSF after an intramuscular injection of 250 mg of cephalothin/kg were, respectively, 1.43 +/- 4.9 microgram/ml (2.8% of peak serum level) and 1.69 +/- 0.57 microgram/ml (2.2% of peak serum level). "
3.	Meningitis 03/01/1980 - "Choroid plexuses isolated from the lateral cerebral ventricles of rabbits with meningitis took up cephalothin in vitro more avidly than desacetylcephalothin (P less than 0.05), and metabolism of cephalothin to desacetylcephalothin by isolated choroid plexuses was demonstrated directly. "

Related Drugs and Biologics

1.	Cephalothin (Cefalotin)

Related Therapies and Procedures

1.	Therapeutics
2.	Intramuscular Injections