propildazine

RN given refers to parent cpd; synonym ISF 2123 refers to di-HCl; structure

Also Known As:

3-hydrazino-6-((2-hydroxypropyl)methylamino)pyridazine; ISF 2123; pildralazine; propildazine dihydrochloride; propyldazine; 3(2H)-pyridazinone, 6-((2-hydroxypropyl)methylamino)-, hydrazone

Networked: 5 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyridazines: 11
    - propildazine: 5

Related Diseases

1.	Hypertension (High Blood Pressure) 01/01/1984 - "Effects of pildralazine alone and in combination on severe hypertension and cerebrovascular lesions in saline-drinking spontaneously hypertensive rats." 11/01/1975 - "[Activity of a new derivative of 3-hydrazinopyridazine: ISF 2123 in patients with hypertension. " 12/01/1986 - "The counter-regulatory effects in response to blood pressure reduction by propyldazine were studied in conscious dogs with bilateral cellophane perinephritis hypertension. " 01/01/1984 - "significantly inhibited the onset of severe hypertension; the combination of pildralazine with moderately effective doses of propranolol (10 mg/kg p.o.) or dihydrochlorothiazide (5 mg/kg p.o.) completely prevented the blood pressure increase. " 03/01/1979 - "[Treatment of severe arterial hypertension with propyldazine (ISF 2123) associated with a diuretic and a beta-blocking agent]."
2.	Tachycardia (Tachyarrhythmias) 10/17/1980 - "The vasodilator antihypertensive propildazine acutely administered in awake dogs (0.1 mg/kg i.v.) produced an arterial blood pressure drop accompanied by tachycardia, decreased urine volume and urinary sodium excretion, and increased urinary potassium excretion. "
3.	Perinephritis 12/01/1986 - "The counter-regulatory effects in response to blood pressure reduction by propyldazine were studied in conscious dogs with bilateral cellophane perinephritis hypertension. "

Related Drugs and Biologics

1.	propildazine
2.	Vasodilator Agents (Vasodilators)
3.	Sodium
4.	Propranolol (Inderal)
5.	Potassium
6.	Hydrochlorothiazide (Esidrix)
7.	Diuretics
8.	Cellophane
9.	Antihypertensive Agents (Antihypertensives)
10.	oxdralazine