variamycin

new glycoside antibiotic from aureolic acid group; disrupts RNA synthesis in Staph aureus, HeLa cells; complexes DNA; russian drug

Also Known As:

variamycin B; 3(C)-demethyl-4(C)-O-methylmithramycin

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

1.	Neoplasms (Cancer) 08/01/1986 - "The histological examination revealed pronounced dystrophic changes or complete resorption of the tumor tissue due to variamycin effect." 08/01/1986 - "One course of the treatment with variamycin started late after the tumor transplantation, i. e. " 11/01/1975 - "Penetration of variamycin, a new antitumor antibiotic into the normal and tumor tissues of the brain of rats with multiform glioblastoma was investigated. "
2.	Astrocytoma (Pilocytic Astrocytoma) 08/01/1986 - "The effect of variamycin, an antibiotic of the group of aureolic acid on development of dedifferentiated astrocytoma of the brain was studied on rabbits. " 02/01/1978 - "The cytotoxic effect of antitumour antibiotics, such as dactinomycin, mithramycin, variamycin and olivomycin on the cells of the human brain tumours (multiform glyoblastoma, arachnoidendotelioma and astrocytoma) grown by the method of the primary plasmic culture was studied. "
3.	Sarcoma (Soft Tissue Sarcoma) 05/01/1972 - "[Effect of variamycin on RNA biosynthesis in isolated cell nuclei of rat M-1 sarcoma and liver]."
4.	Glioblastoma (Glioblastoma Multiforme) 11/01/1975 - "Penetration of variamycin, a new antitumor antibiotic into the normal and tumor tissues of the brain of rats with multiform glioblastoma was investigated. "
5.	Brain Neoplasms (Brain Tumor) 08/01/1986 - "[Effect of the antibiotic variamycin on the growth of a rabbit brain tumor]."

1.	Anti-Bacterial Agents (Antibiotics)
2.	Plicamycin
3.	RNA (Ribonucleic Acid)
4.	Olivomycins
5.	Dactinomycin (Actinomycin)

1.	Transplantation