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estropipate (Ogen)

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used therapeutically in menopausal patients

Also Known As:

Ogen; Ortho-Est; Genoral; Harmogen; Harmonet; Knoll brand of estropipate; Pfizer brand of estropipate; Women First brand of estropipate; piperazine estrone sulfate; estra-1,3,5(10)-trien-17-one, 3-(sulfooxy)-, compd. with piperazine (1:1)

Networked: 310 relevant articles (10 outcomes, 31 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Degen, Jay L: 13 articles (10/2015 - 12/2002)
2.	Flick, Matthew J: 10 articles (10/2015 - 01/2005)
3.	Palumbo, Joseph S: 9 articles (10/2015 - 12/2002)
4.	Talmage, Kathryn E: 5 articles (04/2010 - 10/2003)
5.	Degen, J L: 5 articles (12/2001 - 01/2000)
6.	Raghu, Harini: 4 articles (10/2015 - 09/2011)
7.	Gando, Satoshi: 4 articles (01/2015 - 07/2011)
8.	Alves, Christina S: 4 articles (01/2012 - 04/2008)
9.	Konstantopoulos, Konstantinos: 4 articles (01/2012 - 04/2008)
10.	Drew, A F: 4 articles (12/2001 - 01/2000)

Related Diseases

1.	Neoplasms (Cancer) 12/15/1990 - "The fibrin(ogen) coating on the surface of these tumor cells provides protection against the lytic effect of autologous lymphokine-activated killer cells." 01/01/2005 - "These studies establish an important link between hemostatic factors and innate immunity and indicate that one mechanism by which the platelet-fibrin(ogen) axis contributes to metastatic potential is by impeding natural killer cell elimination of tumor cells." 01/01/2001 - "Rather, tumor cell fate studies argued that there is an important role of fibrin(ogen) in the sustained adhesion and/or survival of tumor cell emboli within the lung. " 11/15/2000 - "Rather, tumor cell fate studies indicated an important role for fibrin(ogen) in sustained adhesion and survival of tumor cells within the lung. " 04/01/2012 - "A seminal property of fibrin(ogen) driving tumor formation in this context is the capacity to support local leukocyte activation events through engagement of the leukocyte integrin α(M)β(2). "
2.	Neoplasm Metastasis (Metastasis) 07/01/2007 - "One mechanism linking TF to metastasis is through a fibrin(ogen)-dependent and platelet-dependent restriction in natural killer cell-mediated clearance of micrometastases. " 04/01/2012 - "Several reports have shown that the platelet/fibrin(ogen) axis supports metastasis by limiting natural killer cellmediated lysis of newly-localized micrometastases. " 01/01/2001 - "Together, the results of studies from our laboratory, as well as the laboratories of others, indicate that the presence of fibrin(ogen) within the tumor stroma likely affects the progression of tumor cell growth and metastasis. " 01/01/2012 - "In view of the roles of PDGF, fibrin(ogen) and CD44 in cancer metastasis, we aimed to delineate the effect of PDGF on CD44-fibrin recognition. " 02/01/2006 - "Targeting the plasmin(ogen) cascade may provide a new insight into molecular target therapy based on anti-invasion and anti-metastasis for pancreatic cancer."
3.	Thrombosis (Thrombus) 09/01/2012 - "These findings laid important groundwork for current in-vivo studies on the role of fibrin(ogen) in hemostasis and thrombosis. " 02/01/2015 - "Besides the well-known pathologic characteristics, this disease also has a vascular component, and substantial evidence shows increased thrombosis as well as a critical role for fibrin(ogen) in AD. " 08/01/2014 - "Undariase, a direct-acting fibrin(ogen)olytic enzyme from Undaria pinnatifida, inhibits thrombosis in vivo and exhibits in vitro thrombolytic properties." 05/01/2014 - "RBC interactions with fibrin(ogen) and cells, including platelets and endothelial cells, may also promote thrombus formation. " 10/06/2011 - "Because fibrin structure plays a key role in clot stability and thrombosis, we hypothesized that FXII(a) interacts with fibrin(ogen) and thereby regulates clot structure and function. "
4.	Atherosclerosis 04/01/2009 - "[Progress of the relationship between fibrin (ogen) and atherosclerosis]." 02/01/1979 - "Fibrin(ogen), platelets and a new theory of atherogenesis." 01/01/1994 - "By complexing with fibrin(ogen) in atheromatous lesions, lipoprotein(a) attenuates clearance of this protein, promoting atherogenesis and vascular dysfunction. " 08/01/2013 - "Moreover, brains from AD cases homozygous for APOE ɛ4 showed increased deposition of fibrin(ogen), specifically in CAA- and oligomeric Aβ-positive vessels compared with AD APOE ɛ2 and ɛ3 allele carriers, an effect that was not directly linked to CAA severity and cerebrovascular atherosclerosis. " 12/18/2009 - "The finding provides a new mechanism for atherogenic effect of fibrin(ogen) and FDP, and emphasizes the importance of therapy of hyperfibrinogenemia in atherosclerosis."
5.	Vascular System Injuries 09/01/2005 - "The effect of FXIII Val34Leu polymorphism on fibrin(ogen) cross-linking in vivo when vascular injury triggers the blood coagulation has not been studied yet. " 05/31/1994 - "Fibrin(ogen) is important for hemostasis and is cleared from sites of vascular injury primarily by the plasminogen activator system. " 09/01/2012 - "As such, fibrin(ogen) lies at the nexus of vascular injury and repair. " 04/01/1997 - "In conclusion, mural fibrin(ogen) thrombus formation and incorporation contribute to neointima formation after deep vascular injury and seem to occur for several weeks after the initial insult." 09/01/1999 - "The possible significance of this plasmin:thrombin ratio is discussed in respect to the turnover of fibrin(ogen) within the site of vascular injury."

Related Drugs and Biologics

1.	Fibrin
2.	Fibrinolysin
3.	Plasminogen Activators (Plasminogen Activator)
4.	Antibodies
5.	Peptide Hydrolases (Proteases)
6.	Lipoprotein(a)
7.	Enzymes
8.	Therapeutic Uses
9.	Phosphopyruvate Hydratase (Enolase)
10.	Carrier Proteins (Binding Protein)

Related Therapies and Procedures

1.	Hormone Replacement Therapy (Therapy, Hormone Replacement)
2.	Aftercare (After-Treatment)
3.	Catheters
4.	Microspheres (Microsphere)
5.	Laser Corneal Surgery