lipoteichoic acid

lipopolysaccharides with an acyl group anchored to the cell membrane of gram-positive bacteria; functions as an adhesion molecule to facilitate the binding of bacteria to cells, colonization, and invasion; interacts with CD14 to induce NF-κB activation and inflammatory cytokine production; can function as surface antigen; inhibits remineraliztion of artificial lesions and surface-softened enamels;

Also Known As:

Networked: 242 relevant articles (3 outcomes, 27 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	van der Poll, Tom: 10 articles (11/2014 - 05/2002)
2.	Chung, Dae Kyun: 7 articles (01/2015 - 02/2008)
3.	Han, Seung Hyun: 7 articles (02/2014 - 10/2003)
4.	Mohamadzadeh, Mansour: 6 articles (01/2013 - 03/2011)
5.	Draing, Christian: 6 articles (07/2011 - 11/2007)
6.	von Aulock, Sonja: 6 articles (07/2011 - 11/2007)
7.	Zadeh, Mojgan: 5 articles (06/2012 - 03/2011)
8.	Yang, Chuen-Mao: 5 articles (01/2012 - 10/2008)
9.	Jung, Bong Jun: 4 articles (01/2015 - 01/2011)
10.	Kang, Seok-Seong: 4 articles (02/2014 - 02/2011)

Related Diseases

1.	Infection 04/01/2015 - "Anti-lipoteichoic acid monoclonal antibody (pagibaximab) studies for the prevention of staphylococcal bloodstream infections in preterm infants." 04/01/2015 - "Extraplacental membranes were cultured for 4, 8, and 24h with the TCE metabolites trichloroacetate (TCA) or S-(1,2-dichlorovinyl)-l-cysteine (DCVC) in the absence or presence of lipoteichoic acid (LTA) or lipopolysaccharide (LPS) to simulate infection. " 02/01/2015 - "Virulence was dependent on the presence of the GBS capsule, surface anchored lipoteichoic acid (LTA) and toxin production, as infection with GBS mutants lacking these factors resulted in little to no mortality. " 12/01/2013 - "Investigating the candidacy of a lipoteichoic acid-based glycoconjugate as a vaccine to combat Clostridium difficile infection." 03/01/2013 - "Lipoteichoic acid (LTA) is an important bacterial component of Staphylococcus aureus, which is one of the common human pathogens for severe respiratory infection with increasing morbidity in recent years. "
2.	Chronic Obstructive Pulmonary Disease (COPD) 02/01/2014 - "Resveratrol attenuates the release of inflammatory cytokines from human bronchial smooth muscle cells exposed to lipoteichoic acid in chronic obstructive pulmonary disease." 07/01/2012 - "The aim of this study was to evaluate the effects of lipoteichoic acid (LTA), a danger signal from gram-positive bacteria, on T cell cytokines related to bacterial infection defense in COPD and asthma. " 07/01/2012 - "Effect of lipoteichoic acid on IL-2 and IL-5 release from T lymphocytes in asthma and COPD." 02/01/2014 - "We suggested that human airway smooth muscle cells (HASMCs) release COPD-associated cytokines/chemokines in response to lipoteichoic acid (LTA), a major PAMP of gram-positive bacteria and that resveratrol is superior to the corticosteroid dexamethasone in suppressing these cytokines/chemokines. "
3.	Shock 12/01/2013 - "Peripheral blood mononuclear cells (PBMCs) of patients and controls were stimulated by Streptococcus sanguinis, lipopolysaccharide (LPS), lipoteichoic acid (LTA), and heat shock protein-60 (HSP-60) for three hours. " 02/15/2008 - "Lipoteichoic acid isolated from Lactobacillus plantarum inhibits lipopolysaccharide-induced TNF-alpha production in THP-1 cells and endotoxin shock in mice." 12/01/2007 - "In additional experiments, rats were challenged with lipopolysaccharide (1 mg/kg) and subjected to Gram-negative (lipopolysaccharide) or Gram-positive (lipoteichoic acid and peptidoglycan) shock 24 hrs later. " 04/01/2005 - "Heat shock also increased lipoteichoic acid- or lipopolysaccharide-induced interleukin-6 production by monocytes. " 08/01/2001 - "In group 4 rats, Gram-positive shock was induced by coadministration of lipoteichoic acid (3 mg/kg intravenously) and peptidoglycan (10 mg/kg intravenously) (n = 10). "
4.	Hypotension (Low Blood Pressure) 08/01/2001 - "In vivo, administration of lipoteichoic acid/peptidoglycan or lipopolysaccharide resulted within 6 hrs in hypotension, acute renal dysfunction, hepatocellular injury, and lung injury. " 08/01/1996 - "ABT-299 (.1 mg/kg) was also effective in preventing hypotension and gastrointestinal damage induced by lipoteichoic acid (LTA), a putative causative agent of shock in Gram-positive infections. "
5.	Dental Caries (White Spot) 08/01/1982 - "Immunisation of rhesus monkeys with Streptococcus mutans, Lactobacillus acidophilus and lipoteichoic acid for protection against dental caries." 08/01/1982 - "An attempt was made to protect rhesus monkeys from dental caries by immunisation with Streptococcus mutans, Lactobacillus acidophilus and lipoteichoic acid (LTA). "

Related Drugs and Biologics

1.	Cytokines
2.	Chemokines
3.	Dexamethasone (Maxidex)
4.	ABT 299
5.	resveratrol
6.	Peptidoglycan (Murein)
7.	Toll-Like Receptors (Toll-Like Receptor)
8.	Proteins (Proteins, Gene)
9.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
10.	Vaccines

Related Therapies and Procedures

1.	Pleurodesis
2.	Joint Prosthesis
3.	Intravenous Injections
4.	Intraperitoneal Injections
5.	Critical Care