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divinyl sulfone

cross-linking reagent for agarose gels

Also Known As:

vinyl sulfone

Networked: 28 relevant articles (1 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Sulfur Compounds: 278
  - Sulfones: 534
    - divinyl sulfone: 28

Experts

1.	Reed, Sharon L: 3 articles (01/2018 - 06/2010)
2.	Caffrey, Conor R: 2 articles (01/2021 - 01/2007)
3.	Roush, William R: 2 articles (01/2021 - 06/2010)
4.	Choi, Ji Won: 2 articles (07/2019 - 01/2019)
5.	Kim, Hyeon Jeong: 2 articles (07/2019 - 01/2019)
6.	Pae, Ae Nim: 2 articles (07/2019 - 01/2019)
7.	Park, Jong-Hyun: 2 articles (07/2019 - 01/2019)
8.	Park, Ki Duk: 2 articles (07/2019 - 01/2019)
9.	Shin, Su Jeong: 2 articles (07/2019 - 01/2019)
10.	Hirata, Ken: 2 articles (01/2018 - 06/2010)

Related Diseases

1.	Schistosomiasis (Bilharziasis) 01/01/2021 - "Druggable Hot Spots in the Schistosomiasis Cathepsin B1 Target Identified by Functional and Binding Mode Analysis of Potent Vinyl Sulfone Inhibitors." 01/01/2007 - "The significant reduction in parasite burden and pathology by this vinyl sulfone cysteine protease inhibitor validates schistosome cysteine proteases as drug targets and offers the potential of a new direction for chemotherapy of human schistosomiasis."
2.	Schistosomiasis mansoni 01/01/2007 - "The efficacy of the vinyl sulfone cysteine protease inhibitor K11777 was tested in the murine model of schistosomiasis mansoni. "
3.	Disease Progression 09/01/2012 - "Recent advances in a class of vinyl sulfone inhibitors are encouraging; however, as most potential therapeutics fail in clinical trials and both disease progression and resistance call for combination therapy with several drugs, the identification of additional classes of inhibitory molecules is essential. "
4.	Leukemia 10/01/2000 - "In this study, we demonstrate that cell-permeable proteasome inhibitors, lactacystin, benzyloxycarbonyl(Z)-leucyl-leucyl-leucinal (ZLLLal; MG-132) and 4-hydroxy-5-iodo-3-nitrophenylacetyl-leucyl-leucyl-leucine vinyl sulfone (NLVS), induce apoptosis abundantly in p53-defective leukemic cell lines CCRF-CEM, U937 and K562 as well as in myelogenic and lymphatic leukemic cells obtained from adult individuals with relapsed acute leukemias. "
5.	Glaucoma 01/01/2019 - "STATEMENT OF SIGNIFICANCE: A new model to study chronic neurodegeneration in glaucoma has been developed via intracameral injection of a specifically designed hyaluronic acid functionalized with vinyl sulfone and thiol groups for cross-linking. "

Related Drugs and Biologics

1.	Cysteine Proteases (Cysteine Protease)
2.	Cysteine Proteinase Inhibitors
3.	N- pip- phenylalanine- homophenylalanine- vinyl sulfone phenyl
4.	Proteasome Inhibitors
5.	Sulfhydryl Compounds (Thiols)
6.	Hyaluronic Acid (Hyaluronan)
7.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde
8.	lactacystin
9.	leucinal
10.	Peptide Hydrolases (Proteases)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Therapeutics
3.	Intracameral Injection