connective tissue-activating peptide (CTAP-III)

slightly basic saline soluble polypeptide extractable from many tissues; induces hypermetabolic activity in cultivated human synovial cells 10,000-15,000

Also Known As:

CTAP-III; CATP-III (de 1-15); CTAP (connective tissue-activating peptides); CTAP-I; CTAP-II; CTAP-III (connective tissue activating peptide); CTAP3 protein; connective tissue activating peptide-I; connective tissue activating peptide-II; connective tissue activating peptide-III; connective tissue activating peptide-III (des 1-15); connective tissue-activating peptides; neutrophil activating peptide-2; rCTAP-III-Leu-21 (des 1-15)

Networked: 42 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - connective tissue-activating peptide: 42

Experts

1.	Brandt, Ernst: 2 articles (07/2004 - 02/2002)
2.	Eldor, A: 2 articles (12/2000 - 10/2000)
3.	Friedmann, Y: 2 articles (12/2000 - 10/2000)
4.	Vlodavsky, I: 2 articles (12/2000 - 10/2000)
5.	Bencsikova, Beatrix: 1 article (06/2013)
6.	Demlova, Regina: 1 article (06/2013)
7.	Greplova, Kristina: 1 article (06/2013)
8.	Klement, Giannoula Lakka: 1 article (06/2013)
9.	Pilatova, Katerina: 1 article (06/2013)
10.	Zdrazilova-Dubska, Lenka: 1 article (06/2013)

Related Diseases

1.	Lung Neoplasms (Lung Cancer) 06/10/2009 - "In two independent population cohorts, CTAP III/NAP-2 was significantly associated with lung cancer and improved the accuracy of a lung cancer risk prediction model that included age, smoking, lung function (FEV(1)), and an interaction term between FEV(1) and CTAP III/NAP-2 (area under the curve, 0.84; 95% CI, 0.77 to 0.91) compared to CAPIII/NAP-2 alone. " 05/15/2011 - "Our findings demonstrate elevated plasma levels of CTAP-III occur in lung cancer patients. " 05/15/2011 - "We also quantified and verified the increased levels of plasma CTAP-III with ELISA in patients with lung cancer (mean ± SD, 1859 ± 1219 ng/mL) compared to controls (698 ± 434 ng/mL; P<0.001). " 08/22/2012 - "As a demonstration of the approach, we report the rapid development of a made-to-order electronic sensor for a newly reported early biomarker for lung cancer (CTAP III/NAP2). " 06/10/2009 - "We identified CTAP III/NAP-2 as a novel biomarker to detect preclinical lung cancer. "
2.	Uterine Cervical Neoplasms (Cancer of the Cervix) 10/01/2000 - "The aim of this study was to explore the possible involvement of CTAP-III in the development of cervical cancer as it progresses through several cervical intraepithelial neoplasia (CIN) stages. "
3.	Uterine Cervical Dysplasia 10/01/2000 - "The aim of this study was to explore the possible involvement of CTAP-III in the development of cervical cancer as it progresses through several cervical intraepithelial neoplasia (CIN) stages. "
4.	Inflammation (Inflammations) 03/01/1988 - "Connective tissue-activating peptide released at the inflammation site could be having a systemic effect. " 01/01/1973 - "V. The flux of connective tissue activating peptide during acute inflammation." 10/17/2006 - "Increased levels of neutrophil-activating peptide-2 in acute coronary syndromes: possible role of platelet-mediated vascular inflammation." 02/21/1997 - "NAP-2 strongly stimulates neutrophils that are present during inflammation whereas its precursors, PBP and CTAP-III, are inactive, although they also possess the highly conserved, amino-terminal sequence, Glu-Leu-Arg (ELR), that is critical for receptor binding. " 06/01/1984 - "Connective tissue activating peptide III (CTAP-III) is a platelet factor that induces, in cultured connective tissue cells, activities observed in chronic inflammation. "
5.	Melanoma (Melanoma, Malignant) 01/17/1997 - "Neutrophil-activating peptide-2 and melanoma growth-stimulatory activity are functional as monomers for neutrophil activation." 06/01/1995 - "Other prominent members are melanoma growth stimulatory activity (GRO-alpha), neutrophil-activating peptide-2, and epithelial-cell derived neutrophil-activating protein 78. " 03/01/1993 - "Molecular characterization of receptors for human interleukin-8, GRO/melanoma growth-stimulatory activity and neutrophil activating peptide-2." 10/01/1992 - "ENA-78 shares significant amino acid sequence homology with neutrophil activating peptide-2 (NAP-2; 53%), growth regulated oncogene/melanoma growth stimulatory activity (GRO alpha; 52%), and IL-8 (22%). " 01/17/1997 - "Neutrophil-activating peptide-2 (NAP-2) and melanoma growth-stimulatory activity (MGSA) are members of the chemokine family of inflammatory proteins. "

Related Drugs and Biologics

1.	Interleukin-8 (Interleukin 8)
2.	connective tissue-activating peptide (CTAP-III)
3.	Proteins (Proteins, Gene)
4.	Peptides (Polypeptides)
5.	CXC Chemokines
6.	Platelet Factor 4
7.	Chemotactic Factors
8.	Protein Isoforms (Isoforms)
9.	Chemokines
10.	Biomarkers (Surrogate Marker)