pirlindole

RN given refers to parent cpd; synonym pyrazidol refers to mono-HCl; structure in Negwer, 5th ed, #2812

Also Known As:

1,10-trimethylene-8-methyl-1,2,3,4-tetrahydropyrazino(1,2-a)indole; pirlindol; pirlindole hydrochloride; pyrazidol; pyrlindole; 1H-Pyrazino(3,2,1-jk)carbazole, 2,3,3a,4,5,6-hexahydro-8-methyl-, monohydrochloride

Networked: 26 relevant articles (3 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Indoles: 200
      - Carbazoles: 32
        pirlindole: 26
  - 3-Ring Heterocyclic Compounds
    - Carbazoles: 32
      - pirlindole: 26

Experts

1.	Filipe, Augusto: 2 articles (12/2014 - 10/2011)
2.	Shabanov, P D: 2 articles (01/2005 - 07/2004)
3.	Zarubina, I V: 2 articles (01/2005 - 07/2004)
4.	Almeida, Susana: 1 article (12/2014)
5.	Bessa, João M: 1 article (12/2014)
6.	Mateus-Pinheiro, António: 1 article (12/2014)
7.	Morais, Mónica: 1 article (12/2014)
8.	Patrício, Patrícia: 1 article (12/2014)
9.	Pedroso, Pedro: 1 article (12/2014)
10.	Pinto, Luísa: 1 article (12/2014)

Related Diseases

1.	Pain (Aches) 04/18/2012 - "Pirlindole showed statistically significant results compared with placebo for several outcomes (pain, tender points and overall assessment by the patient and the physician), whereas moclobemide did not show statistically significant differences between groups. "
2.	Fibromyalgia (Fibrositis) 10/01/2011 - "The available evidence supports pirlindole as a safe and effective treatment option for the management of depression and fibromyalgia syndrome." 10/01/2011 - "Pirlindole in the treatment of depression and fibromyalgia syndrome."
3.	Brain Injuries (Brain Injury) 01/01/2005 - "[Efficacy of bemithyl and pyrazidol in patients with cerebroasthenia due to brain injury]." 01/01/2005 - "The article is dedicated to therapeutic efficacy of a combination of the antihypoxant bemithyl and the antidepressant pyrazidol in patients with asthenoneurotic and asthenovegetative syndromes after moderate isolated brain injury (BI). "
4.	Dehydration (Water Stress) 11/01/1987 - "Analysis of electron absorption spectra and polarographic studies demonstrated that inhibition of MAO by pyrazidol resulted in dehydration of the piperazine ring in the molecule of the drug as well as in possible formation of azomethine bond at the 2-3 position, exhibiting high oxidizing activity. " 01/01/1981 - "Monoamine oxidase inhibitors /trans-2-phenylcyclopropylamine, pyrazidol, phenharmane/ belonging to the category of primary or secondary amines, in the molecule of which/ after dehydration/ formation of an azomethine bond is possible, modified the activity of membrane bound bovine brain monoamine oxidases inhibiting the deamination of serotonin and, at the same time, causing appearance of or significant increase in cadaverine--or histamine--deaminating properties. "
5.	Hypoxia (Hypoxemia) 05/01/1998 - "[Level of monoamines during hypobaric hypoxia and protective effect of pyrazidol]." 07/01/1994 - "A possible role of the MMM fraction in the pyrazidol-produced adaptation effect during hypoxia is discussed." 07/01/1994 - "The protective effect of pyrazidol under intermittent hypoxia is discussed." 07/01/1994 - "Pyrazidol administration under 10-day hypoxia prevents the SOD activity decrease in the brain. " 07/01/1994 - "The activity of SOD increases in the brain and the lung of pyrazidol-protected animals under 3-day hypoxia. "

Related Drugs and Biologics

1.	Antidepressive Agents (Antidepressants)
2.	Moclobemide (Arima)
3.	bemethyl
4.	Monoamine Oxidase (MAO)
5.	azomethine
6.	Piperazine
7.	Imipramine (Janimine)
8.	Serotonin (5 Hydroxytryptamine)
9.	Oxidoreductases (Dehydrogenase)
10.	Monoamine Oxidase Inhibitors (Monoamine Oxidase Inhibitor)