2,2',2''-trichlorotriethylamine (HN 3)

RN given refers to parent cpd; structure

Also Known As:

HN 3; 2,2',2''-trichloroethylamine; 2,2',2''-trichlorotriethylamine hydrochloride; 2,2',2''-trichlorotriethylamine monopicrate; HN-3; TS-160; trichloromethine; trichlorotriethylamine; tris(2-chloroethyl)amine; tris(beta-chloroethyl)amine; 2-chloro-N,N-bis(2-chloroethyl)ethanamine

Networked: 16 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Halogenated Hydrocarbons: 42
    - Mustard Compounds: 3
      - Nitrogen Mustard Compounds: 2
        2,2',2''-trichlorotriethylamine: 16

Experts

1.	Liu, Zhi-bin: 3 articles (04/2011 - 02/2009)
2.	Niu, Wen-min: 3 articles (04/2011 - 02/2009)
3.	Niu, Xiao-mei: 3 articles (04/2011 - 02/2009)
4.	He, Peijie: 2 articles (09/2016 - 08/2015)
5.	Zhou, Liang: 2 articles (09/2016 - 08/2015)
6.	Yang, Xiao-hang: 2 articles (04/2011 - 02/2009)
7.	Lin, Yu-Fen: 1 article (12/2017)
8.	Lu, Jian-Min: 1 article (12/2017)
9.	Su, Yan-Na: 1 article (12/2017)
10.	Zhang, Zuo-Dan: 1 article (12/2017)

Related Diseases

1.	Leukemia 05/04/1984 - "Use of methyl-bis(beta-chloroethyl)amine hydrochloride and tris(beta-chloroethyl)amine hydrochloride for Hodgkin's disease, lymphosarcoma, leukemia and certain allied and miscellaneous disorders. " 02/01/2011 - "To observe the effect of electroacupuncture (EA) of "Xiusanzhen" [3 acupoints, i.e., bilateral "Yingxiang" (LI 20) and "Yintang" (EX-HN 3)] on expression of B-cell lymphoma/leukemia-2 (Bcl-2, an antiapoptosis protein) and Bax (a protein for promoting apoptosis) in the hippocampus in Alzheimer disease (AD) rats, so as to explore its clinical mechanisms underlying relieving AD. " 09/21/1946 - "Nitrogen mustard therapy; use of methyl-bis (beta-chloroethyl) amine hydrochloride and tris (beta-chloroethyl) amine hydrochloride for Hodgkin's disease, lymphosarcoma, leukemia and certain allied and miscellaneous disorders." 08/01/1987 - "The antitumor effect of flavone acetic acid, LM975, and its diethylaminoethyl ester derivative, LM985, was studied in four human malignant cell lines [WiDr, a colon carcinoma; LICR (LON) HN-3, a tongue carcinoma; MCF7, a breast carcinoma; K-562, a leukemia] using a colorimetric assay based on the reduction of dimethylthiazol-2-yl-diphenyltetrazolium. "
2.	Alzheimer Disease (Alzheimer's Disease) 04/01/2011 - "To explore the effect of "Xiusanzhen" [electroacupuncture (EA) of bilateral "Yingxiang" (LI 20) and "Yintang" (EX-HN 3)] on activities of hippocampal muscarinic cholinergic receptor (mAChR) and the involved neural path in Alzheimer Disease(AD)rats. " 02/01/2009 - "To explore the effect of "Xiusanzhen" [bilateral "Yingxiang" (LI 20) + "Yintang" (EX-HN 3)] on learning-memory ability and choline acetyl transferase (ChAT) and acetyl cholinesterase (AChE) activity of hippocampus tissue in Alzheimer Disease (AD) rats. " 02/01/2011 - "To observe the effect of electroacupuncture (EA) of "Xiusanzhen" [3 acupoints, i.e., bilateral "Yingxiang" (LI 20) and "Yintang" (EX-HN 3)] on expression of B-cell lymphoma/leukemia-2 (Bcl-2, an antiapoptosis protein) and Bax (a protein for promoting apoptosis) in the hippocampus in Alzheimer disease (AD) rats, so as to explore its clinical mechanisms underlying relieving AD. "
3.	Phototoxic Dermatitis (Phototoxicity) 08/01/2015 - "Phototoxicity and apoptosis on HN-3 cells induced by 9-HPbD-PDT was exhibited in a dose-related manner. " 09/01/2016 - "Phototoxicity initiated by 9-HPbD-PDT on HN-3 cells was observed in a photosensitizer dose-dependent pattern. "
4.	Non-Hodgkin Lymphoma (Lymphosarcoma) 05/04/1984 - "Use of methyl-bis(beta-chloroethyl)amine hydrochloride and tris(beta-chloroethyl)amine hydrochloride for Hodgkin's disease, lymphosarcoma, leukemia and certain allied and miscellaneous disorders. " 09/21/1946 - "Nitrogen mustard therapy; use of methyl-bis (beta-chloroethyl) amine hydrochloride and tris (beta-chloroethyl) amine hydrochloride for Hodgkin's disease, lymphosarcoma, leukemia and certain allied and miscellaneous disorders."
5.	Hodgkin Disease (Hodgkin's Disease) 05/04/1984 - "Use of methyl-bis(beta-chloroethyl)amine hydrochloride and tris(beta-chloroethyl)amine hydrochloride for Hodgkin's disease, lymphosarcoma, leukemia and certain allied and miscellaneous disorders. " 09/21/1946 - "Nitrogen mustard therapy; use of methyl-bis (beta-chloroethyl) amine hydrochloride and tris (beta-chloroethyl) amine hydrochloride for Hodgkin's disease, lymphosarcoma, leukemia and certain allied and miscellaneous disorders."

Related Drugs and Biologics

1.	Photosensitizing Agents (Photosensitizers)
2.	Mechlorethamine (Nitrogen Mustard)
3.	Amines
4.	Cholinergic Agents (Cholinergics)
5.	Transferases
6.	Cholinergic Receptors
7.	Proteins (Proteins, Gene)
8.	Nitrogen
9.	Esters
10.	Cholinesterases (Cholinesterase)

Related Therapies and Procedures

1.	Electroacupuncture
2.	Acupuncture Points (Acupuncture Point)
3.	Semiconductor Lasers
4.	Therapeutics
5.	Photochemotherapy (Photodynamic Therapy)