polyanions

11/01/2023 - "This review will outline the different mechanisms through which PF4 engagement with polyanions combats infection but also contributes to the pathogenesis of inflammatory and thrombotic disease states. "
11/28/2011 - "Infection by either pathogen has been found to be inhibited by polyanions. "
05/05/1997 - "Sulfated polyanions, however, inhibited baculovirus infection of BTI-TN5B1-4. "
09/01/1995 - "Results of infection at 4 degrees C suggest that sulfated polyanions act by preventing the adherence of chlamydiae to target cells. "
09/01/1995 - "Sulfated polyanions block Chlamydia trachomatis infection of cervix-derived human epithelia."

09/01/1990 - "The present study, combined with the results of quantitative analysis with image analyzer for alteration of glomerular polyanions, suggests that both morphologic changes and proteinuria may be the consequence of a common primary event that is the loss of glomerular polyanions. "
07/01/1981 - "These studies provide direct evidence that neutralization of glomerular polyanions in vivo results in heavy proteinuria. "
12/01/1987 - "Several lines of evidence indicate that the proteinuria results from binding of HDM to polyanions of the glomerular filter, with neutralization of shielding of their charges. "
04/01/1984 - "Stainable glomerular basement membrane polyanions and renal hemodynamics during hexadimethrine-induced proteinuria."
07/01/1977 - "These results with D and DS suggest that proteinuria in PAN nephrosis is due, not to an increase in effective pore radius or number of pores, but rather to a diminution of the electrostatic barrier function of the glomerular capillary wall, thereby allowing increased passage of polyanions such as DS and albumin."

08/15/1990 - "Recent studies have demonstrated that sulfated polyanions (SP) are potent inhibitors of HIV infection in vitro, appearing to inhibit virus attachment. "
09/01/1994 - "Sulfated polyanions prevent HIV infection of lymphocytes by disruption of the CD4-gp120 interaction, but do not inhibit monocyte infection."
09/01/1995 - "Because (a) sexual intercourse is a major route of infection with human immunodeficiency virus (HIV); (b) due to the species-specificity of HIV, there is no small animal model to study intra-vaginal HIV infection; (c) HIV is equally or even more sensitive than HSV-2 to several polyanions; and (d) sulfated polymers may prevent the adhesion of (HIV-infected) lymphocytes to epithelial cells, we evaluated the effect of the compounds on intravaginal infection of mice with HSV-2. "
11/28/2011 - "Specific polyanions that inhibit HIV infection and bind to the V3 loop of X4 strains also inhibited DBP-mediated infection of erythrocytes and DBP binding to the Duffy Antigen Receptor for Chemokines (DARC). "

09/01/1986 - "Studies of polyanions that suppress scrapie have been done to pinpoint the cell types in the lymphoreticular system which are important in pathogenesis and to suggest possible prophylactic or therapeutic strategies for the unconventional slow viruses. "
09/15/1999 - "The differences in the binding strengths of recPrP to pentosan polysulphate and to other sulphated polyanions were found to parallel their in vivo anti-scrapie and in vitro anti-scrapie-specific PrP formation potencies. "
03/01/1992 - "Sulphate polyanions prolong the incubation period of scrapie-infected hamsters."
02/03/2011 - "These results show that polyanions >5 bases in length are not required for maintaining the infectious properties of in vitro-generated scrapie prions, and indicate that such properties are maintained either by short polyanion remnants, other co-purified cofactors, or by PrP(Sc) molecules alone."
02/03/2011 - "Single-stranded polyanions ≥40 bases in length facilitate the formation of hamster scrapie prions in vitro, and polyanions co-localize with PrP(Sc) aggregates in vivo. "

05/28/2009 - "Activity and interactions of liposomal antibiotics in presence of polyanions and sputum of patients with cystic fibrosis."
12/01/2013 - "On the other hand, dextran and polyanions enhanced DNase I effect in reducing cystic fibrosis mucus viscosity. "
06/01/1996 - "Neutrophil elastase, a major effector of tissue destruction in the lungs of patients with cystic fibrosis, is a highly cationic molecule which is bound and inhibited by negatively charged polyanions such as mucin and DNA in purulent sputum. "
09/01/2007 - "The goal of this study was to evaluate the effects of DNA and F-actin [polyanions present in high concentration in cystic fibrosis (CF) airway fluid] on the antibacterial activities of the cationic steroid antibiotic CSA-13 and the cationic peptides LL37, WLBU2 and HB71. "