4-pentenoic acid

03/01/1975 - "Production of the features of Reye's syndrome in rats with 4-pentenoic acid."
09/01/1990 - "Microvesicular fatty liver in rats with resembling Reye's syndrome induced by 4-pentenoic acid."
09/01/2014 - "This study was designed to investigate whether resveratrol could provide protection against Reye's syndrome induced by 4-pentenoic acid in Wistar albino rats. "
10/01/1991 - "Histological and biochemical approaches were used to examine the effect of this prostaglandin on hepatocellular damage in an experimental Reye's syndrome model produced in rats by 4-pentenoic acid. "
08/01/1990 - "The effects of 4-pentenoic acid, a chemical claimed to induce fatty liver morphologically similar to that seen in Reye's syndrome, on carnitine metabolism and on hepatic histology were studied. "

01/01/1979 - "Electronmicroscopic and energic aspects in 4-pentenoic acid induced-fatty liver model of Reyes syndrome."
09/01/1990 - "Microvesicular fatty liver in rats with resembling Reye's syndrome induced by 4-pentenoic acid."
08/01/1990 - "Carnitine metabolism in rats with 4-pentenoic acid induced fatty liver."
08/01/1990 - "The effects of 4-pentenoic acid, a chemical claimed to induce fatty liver morphologically similar to that seen in Reye's syndrome, on carnitine metabolism and on hepatic histology were studied. "

08/15/1979 - "Inhibition of fatty acid oxidation by pent-4-enoate in the suckling animal mimics the effect of starvation on the pattern of hepatic gluconeogenic metabolites. "
04/15/1984 - "Rats treated with six to eight doses (80 mg/kg, i.p.) of 4-pentenoic acid, an inhibitor of mitochondrial fatty acid oxidation in vitro, during a 48-hr starvation period developed microvesicular fatty infiltration of the liver similar to that observed in Reye's Syndrome. "

12/01/2007 - "In rats with experimental encephalopathy caused by intoxication with 4-pentenoic acid inhibiting beta-oxidation of medium- and long-chain fatty acids, hepatoprotector silimarin inhibited LPO, prevented deenergization and maintained high respiratory activity of brain mitochondria, and increased the rate and coupling of oxidation and phosphorylation. "
03/01/2007 - "In the tests on rats with a model of encephalopathy caused by 4-pentenoic acid (inhibitor of the beta-oxidation of fatty acids), the hepatoprotective agent silymarin increases the respiratory activity in brain mitochondria, improves oxidative phosphorylation coupling and energization, and inhibits lipid peroxidation. "

02/01/2017 - "Intraperitoneal administration of 4-pentenoic acid was performed once daily during seven days, the used dosage was 20mg/kg. The treatment of toxic hepatitis was carried with intraperitoneal administration of L-Carnitine 300mg/kg, Corvitine 100mg/kg and concurrent administration of these drugs. "