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4-hydroxyanisole (mequinol)

Subscribe to New Research on 4-hydroxyanisole

depigmenting agent; RN given refers to parent cpd

Also Known As:

mequinol; 4-hydroxyanisole, potassium salt; 4-hydroxyanisole, sodium salt; 4-methoxyphenol; DB brand of 4-hydroxyanisole; Leucodinine B; hydroquinone methyl ether; hydroquinone monomethyl ether; p-hydroxyanisole; para-methoxyphenol

Networked: 35 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Drug Context: Research Results

Organic Chemicals: 58
- Phenols: 309
  - Phenyl Ethers: 4
    - Anisoles
      - 4-hydroxyanisole: 35
- Ethers: 174
  - Methyl Ethers: 14
    - Anisoles
      - 4-hydroxyanisole: 35
  - Phenyl Ethers: 4
    - Anisoles
      - 4-hydroxyanisole: 35

Experts

1.	Moridani, Majid Y: 2 articles (11/2006 - 01/2003)
2.	Masotti, A: 1 article (03/2010)
3.	Di Nuzzo, S: 1 article (03/2010)
4.	Keeling, Jon: 1 article (02/2008)
5.	Epstein, Rachel: 1 article (02/2008)
6.	Benitez, Adolpho: 1 article (02/2008)
7.	Rendon, Marta: 1 article (02/2008)
8.	Cardona, Lina: 1 article (02/2008)
9.	Ortonne, Jean-Paul: 1 article (09/2006)
10.	Cheon, Sophia S: 1 article (01/2003)

Related Diseases

1.	Melanosis (Freckles) 01/01/1982 - "[Confetti depigmentation following application of Leucodinine B on a chloasma]." 02/01/2008 - "Mequinol 2%/tretinoin 0.01% topical solution was an effective and well-tolerated treatment of melasma in men. " 02/01/2008 - "This is the first report describing the use of mequinol 2%/tretinoin 0.01% topical solution for the treatment of melasma in men; there are no reports in women." 02/01/2008 - "We performed a case series assessing the use of mequinol 2%/ tretinoin 0.01% topical solution in 5 men with melasma. " 02/01/2008 - "Mequinol 2%/tretinoin 0.01% topical solution for the treatment of melasma in men: a case series and review of the literature."
2.	Melanoma (Melanoma, Malignant) 11/18/2006 - "In the current work we investigated for the first time the biochemical basis of 4-hydroxyanisole (4-HA) induced toxicity in B16-F0 melanoma cells. " 11/18/2006 - "Biochemical basis of 4-hydroxyanisole induced cell toxicity towards B16-F0 melanoma cells." 04/01/1992 - "Ten female patients with recurrent cutaneous malignant melanoma (MM) confined to the lower limb were treated with 4-hydroxyanisole (4HA) infused intra-arterially. " 01/01/1992 - "4-Hydroxyanisole is a depigmenting agent which has been shown to have activity against malignant melanoma when given intra-arterially in man. " 12/01/1990 - "The pharmacokinetic behaviour of 4-hydroxyanisole (4HA) has been studied in ten female patients with recurrent malignant melanoma confined to the lower limb. "
3.	Hepatocellular Carcinoma (Hepatoma) 01/01/1989 - "An experimental study using human melanoma (NEL-MI), rat hepatoma (Fu5-5), and human kidney (293-31) cell lines was undertaken in order to evaluate the antitumor activity of 4-hydroxyanisole (4-OHA) in vitro. "
4.	Vitiligo 11/01/1981 - "Two men reported previously with vitiligo after occupational exposure to hydroquinone monomethyl ether (HMME) have been reviewed after eight years. " 03/01/2010 - "Depigmentation therapy in vitiligo universalis with cryotherapy and 4-hydroxyanisole." 05/01/2000 - "Our purpose was to evaluate the long-term effectiveness and safety of a combination therapy consisting of topical 4-methoxyphenol (4-MP) cream and Q-switched ruby (QSR) laser in 16 patients with vitiligo universalis. " 05/01/2000 - "Depigmentation therapy in vitiligo universalis with topical 4-methoxyphenol and the Q-switched ruby laser." 11/01/1981 - "Screening for occupational vitiligo in workers exposed to hydroquinone monomethyl ether and to paratertiary-amyl-phenol."
5.	Experimental Melanoma 07/01/1977 - "The drug p-hydroxyanisole (OHA) was found to inhibit the incorporation of 3H-thymidine in the Harding-Passey melanoma cells in culture. " 01/01/1990 - "1.14.18.1) in the cytotoxicity of 4-hydroxyanisole (4HA) in vivo, we have compared the therapeutic effects of 4HA on the B16 melanoma and Harding-Passey melanoma, which differ significantly in their tyrosinase content. " 12/01/1988 - "Cytotoxicity of 4-hydroxyanisole and tyrosinase activity in variant cell lines of B16 melanoma."

Related Drugs and Biologics

1.	Tretinoin (Retinoic Acid)
2.	Oxygen
3.	Monophenol Monooxygenase (Tyrosinase)
4.	Tyrosine (L-Tyrosine)
5.	Phenol (Carbolic Acid)
6.	Quinones
7.	Methylnitronitrosoguanidine (MNNG)
8.	Melphalan (Alkeran)
9.	Melanins (Melanin)
10.	Lomustine (CCNU)

Related Therapies and Procedures

1.	Solid-State Lasers
2.	Cryotherapy (Therapy, Cold)
3.	Lasers (Laser)
4.	Drug Therapy (Chemotherapy)