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iprazochrome
used in prophylaxis of migraine
Also Known As:
1-isopropyl-3-hydroxy-5-semicarbazono-6-oxo-2,3,5,6-tetrahydroindole; 1-isopropylnoradrenochrome-5-monosemicarbazone; Divascan; Migrenon; N-propylnoradrenochrome monosemicarbazone; 2-(1,2,3,6-tetrahydro-3-hydroxy-1-(1-methylethyl)-6-oxo-5H-indol-5-ylidene)hydrazinecarboxamide
Networked:
10
relevant articles (
3
outcomes,
2
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
Fused-Ring Heterocyclic Compounds
2-Ring Heterocyclic Compounds
Indoles: 200
Adrenochrome: 51
iprazochrome: 10
Indolequinones: 12
iprazochrome: 10
Biological Factors: 2472
Biological Pigments: 1
Adrenochrome: 51
iprazochrome: 10
Organic Chemicals: 133
Quinones: 434
Indolequinones: 12
iprazochrome: 10
Related Diseases
1.
Migraine Disorders (Migraine)
03/01/1999 - "
According to our results iprazochrome was found effective in the prophylaxis of migraine.
"
08/01/1997 - "
[Iprazochrome in migraine prevention.
"
09/01/1978 - "
Divascan in migraine prophylaxis.
"
01/01/1975 - "
It appeared from the evaluation of a clinical test of the serotonin antagonist in 22 patients that DIVASCAN proved itself particularly effective in cases of ophthalmic migraine, in the second place in cases of migraena simplex with vegetative accentuation and likewise in cases of migraena cerebellaris.
"
07/01/1977 - "
The effects and side-effects in migraine prophylaxis of placebo, Divascan (1-isopropylnoradrenochrome--5--monosemicarbazone) and pizotifen were compared in a double-blind cross-over study.
"
2.
Pain (Aches)
01/01/1989 - "
Twelve of the 30 patients reported increased pain, 16 reported no effect, and two reported pain relief for some hours after taking iprazochrome.
"
3.
Chronic Pain
01/01/1989 - "
The aim of the study was to investigate the effect of a single dose of iprazochrome and of its short-term administration in patients with chronic pain.
"
4.
Headache (Headaches)
04/01/1987 - "
[Effect of divascan on cerebrovascular circulation, lipid metabolism and hemostasis in patients with vasomotor headache].
"
07/01/1977 - "
Pizotifen gave significantly larger reduction in headache frequency and headache index than Divascan and signficantly more patients stated a preference for pizotifen compared with Divascan.
"
5.
Weight Gain
07/01/1977 - "
Pizotifen had frequent side-effects, mainly drowsiness and weight gain, whereas Divascan in this respect did not differ from placebo.
"
Related Drugs and Biologics
1.
Serotonin Antagonists
2.
iprazochrome
3.
Pizotyline (BC 105)
4.
Ergotamine (Ergotamine Tartrate)
5.
Dihydroergotamine (Agit)
6.
Diazepam (Valium)
Related Therapies and Procedures
1.
Therapeutics