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withaferin A

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antineoplastic from leaves of Withania somnifera Dun.; structure

Also Known As:

5,6-epoxy-4,22,27-trihydroxy-1-oxoergosta-2,24-dienoic acid delta-lactone; (4 beta,5 beta,6 beta,22R)-5,6-epoxy-4,22,27-trihydroxy-1-oxoergosta- 2,24-dien-26-oic acid, delta-lactone

Networked: 128 relevant articles (7 outcomes, 19 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Polycyclic Compounds: 56
- Steroids: 18537
  - Cholestanes
    - Sterols: 480
      - Phytosterols: 402
        Ergosterol: 144
        Withanolides: 31
        withaferin A: 128
    - Cholestenes
      - Ergosterol: 144
        Withanolides: 31
        withaferin A: 128

Experts

1.	Singh, Shivendra V: 15 articles (06/2015 - 01/2008)
2.	Hahm, Eun-Ryeong: 10 articles (06/2015 - 09/2008)
3.	Kwon, Taeg Kyu: 9 articles (01/2015 - 12/2008)
4.	Cohen, Mark S: 8 articles (08/2014 - 09/2010)
5.	Lee, Joomin: 7 articles (06/2015 - 11/2010)
6.	Samadi, Abbas K: 7 articles (06/2013 - 09/2010)
7.	Mohan, Royce: 6 articles (01/2015 - 01/2004)
8.	Bargagna-Mohan, Paola: 6 articles (01/2015 - 01/2004)
9.	Timmermann, Barbara N: 5 articles (08/2014 - 09/2010)
10.	Gunatilaka, A A Leslie: 5 articles (04/2014 - 03/2009)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2009 - "Withaferin A (WA) is an important withanolide holding promise in cancer treatment and as a relatively safe radiosensitive/chemotherapeutic agent, which is present in traces in all parts of Withania somnifera except the leaves, where as it is reported to be present in only two non-Indian chemotypes (South African chemotype/Israel chemotype 1). " 03/01/2011 - "On the basis of this study we propose that in near future LXR-α agonist (Withaferin A) may definitely find its use in the therapeutic interventions directed towards the treatment of cancer." 12/01/2015 - "Withaferin A (WA), a steroidal lactone isolated from ayurvedic medicinal plant Withania somnifera, was shown to inhibit tumor growth by inducing oxidative stress and suppressing NF-κB pathway. " 09/01/2015 - "Treatment with withaferin-A exhibited significant decrease in the volume and weight of tumors as compared to untreated controls. " 01/01/2015 - "Withaferin A (WFA) is an active compound from Withania somnifera and has been reported to exhibit a variety of pharmacological activities such as anti—inflammatory, immunomodulatory and anti—tumor properties. "
2.	Breast Neoplasms (Breast Cancer) 05/01/2014 - "Mechanistic elucidation of the antitumor properties of withaferin a in breast cancer." 01/01/2014 - "Pharmacological levels of Withaferin A (Withania somnifera) trigger clinically relevant anticancer effects specific to triple negative breast cancer cells." 07/01/2013 - "Autophagy fails to alter withaferin A-mediated lethality in human breast cancer cells." 06/28/2013 - "Withaferin A-induced apoptosis in human breast cancer cells is associated with suppression of inhibitor of apoptosis family protein expression." 11/01/2012 - "Withaferin A causes activation of Notch2 and Notch4 in human breast cancer cells."
3.	Infection 06/01/2014 - "The immunoprophylactic and therapeutic potentials of root extracts of Withania somnifera chemotypes (NMITLI-118, NMITLI-101) and pure withanolide-withaferin A was investigated against Leishmania donovani infection in hamsters. " 04/01/2012 - "Withania somnifera chemotypes NMITLI 101R, NMITLI 118R, NMITLI 128R and withaferin A protect Mastomys coucha from Brugia malayi infection." 10/01/2008 - "We observed that the NFkappaB intracellular dislocation at the beginning of the treatment affected therapeutic effectiveness of PS-341, Withaferin A and Wedelolactone; interestingly, the adenoviral vector was highly effective in inducing apopotosis even with NFkappaB being predominantly nuclear at the time of infection. "
4.	Chromosome Breakage 07/01/2008 - "Hamsters pretreated with withaferin-A intraperitonealy 2 h before the injection of DMBA, significantly reduced the frequency of MnPCEs and chromosomal aberrations such as chromosomal break, gap, minute, and fragment. "
5.	Visceral Leishmaniasis (Kala Azar) 06/01/2014 - "Efficacy of Withania somnifera chemotypes NMITLI - 101R, 118R and Withaferin A against experimental visceral leishmaniasis."

Related Drugs and Biologics

1.	9,10-Dimethyl-1,2-benzanthracene (DMBA)
2.	sorafenib (BAY 43-9006)
3.	bortezomib (Velcade)
4.	wedelolactone
5.	Withanolides
6.	Proteins (Proteins, Gene)
7.	Ashwagandha
8.	Proteasome Endopeptidase Complex (Proteasome)
9.	3- rhamnopyranosyl(1- 4)- glucopyranosyl- 12- diacetoxy- 20- hydroxywitha- 5,24- dienolide
10.	Carbon Monoxide

Related Therapies and Procedures

1.	Ayurvedic Medicine (Siddha Medicine)
2.	Heterologous Transplantation (Xenotransplantation)
3.	Oral Administration
4.	Radiotherapy
5.	Induced Hyperthermia (Thermotherapy)