VoSoL
combination drug for treatment of swimmer's ear (otitis externa) containing 3% propanediol diacetate, 2% acetic acid, 0.02% benzethonium chloride in propylene glycol vehicle
Networked: 3
relevant articles (0 outcomes,
0 trials/studies)
Drug Context: Research Results
Related Diseases
| 1. | Ototoxicity
06/01/1990
- " On the basis of the short-term results at 24 hours following drug application, the ototoxicity of Coly-Mycin was calculated to be twice that of Cortisporin, and the ototoxicity of VoSoL four times that of Cortisporin." 11/01/1989
- " The ototoxicity of an otic drop preparation containing 2% acetic acid and 3% propylene glycol (VoSol, Denver Chemical Co., Humacao, PR) was investigated according to measurements of endocochlear potential (EP) and inner ear fluid pH. The application of this preparation to the round window membrane for 30 minutes caused a depression in EP from 80.5 +/- 2.5 mV (mean +/- SD; n = 6) to 11.7 +/- 7.7 mV, and lowered inner ear fluid pH from 7.55 +/- 0.09 to 5.06 +/- 0.19 (n = 6) in perilymph and from 7.52 +/- 0.07 to 5.88 +/- 0.63 (n = 6) in endolymph. " 06/01/1990
- " Frequently used ear drops (Cortisporin otic suspension, Coly-Mycin S Otic, and VoSoL otic solution) were studied for their ototoxicity. " 11/01/1988
- " The ototoxicity of 50% propylene glycol, 70% isopropyl alcohol, 2% acetic acid, Otic Domeboro solution (Miles Pharmaceuticals, West Haven, CT), 1% Gentian violet (Purepac Pharmaceutical, Elizabeth, NJ), Vosol Otic solution (Wallace Laboratories, Cranbury, NJ), Genoptic Ophthalmic solution (Allergan Pharmaceuticals, Irvine, CA), Cortisporin Otic suspension (Burroughs Wellcome, Greenville, NC), Coly-Mycin S Otic (Parke-Davis, Rochester, MI), and Pyocidin Otic (Berlex Laboratories, Cedar Knolls, NJ) was studied in rats according to their effect on the latencies of the second peak of the auditory brainstem responses (ABR) at different sound pressure levels. "
|
|
Related Drugs and Biologics