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toxoflavin

azapteridine antibiotic; structure

Also Known As:

1,6-dimethylpyrimido(5,4-E)-as- triazine-5,7(1H,6H)-dione; xanthothricin; 1,6-dimethylpyrimido(5,4-e)-1,2,4-triazine-5,7(1H,6H)-dione

Networked: 9 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrimidines: 510
    - Pyrimidinones: 71
      - toxoflavin: 9
  - Triazines: 306
    - toxoflavin: 9

Experts

1.	Meirelles, Lucas A: 1 article (01/2022)
2.	Newman, Dianne K: 1 article (01/2022)
3.	Bratovanov, Evgeni V: 1 article (10/2021)
4.	Dose, Benjamin: 1 article (10/2021)
5.	García-Altares, María: 1 article (10/2021)
6.	Hermenau, Ron: 1 article (10/2021)
7.	Hertweck, Christian: 1 article (10/2021)
8.	Hniopek, Julian: 1 article (10/2021)
9.	Kim, Hak Joong: 1 article (10/2021)
10.	Kumpfmüller, Jana: 1 article (10/2021)

Related Diseases

1.	Foodborne Diseases 03/01/1989 - "farinofermentans can cause acute food poisoning, but study on mutagenicity of toxoflavin has not been reported. "
2.	Infections 11/01/2023 - "glumae possesses a member of the DedA family, named DbcA, which we previously showed is required for toxoflavin secretion and virulence in a rice model of infection. " 01/01/2021 - "glumae ΔdbcA strain is compromised for virulence in several BPB infection models and secretes only low amounts of toxoflavin (∼15% of wild-type levels). " 10/01/2021 - "We combine genome mining, metabolic profiling, MALDI-Imaging and UV Raman spectroscopy, to detect, identify and visualize a complex of chemical mediators and toxins produced by the pathogen during the infection process, including toxoflavin, caryoynencin, and sinapigladioside. "
3.	Disease Progression 01/01/2018 - "Here we show that a seed-borne plant pathogenic bacterium, Burkholderia glumae (Bg), and an air-borne plant pathogenic fungus, Fusarium graminearum (Fg), interact to promote bacterial survival, bacterial and fungal dispersal, and disease progression on rice plants, despite the production of antifungal toxoflavin by Bg. "
4.	Poisoning 06/20/2017 - "Twenty-one putative gene clusters with high or moderate similarity to important antibiotic biosynthetic gene clusters were found, including the antitumor agents echoside, bafilomycin, hygrocin, and toxoflavin; the antibacterial/antifungal agents nigericin, skyllamycin, kanamycin, naphthomycin, eco-02301, and bottromycin A2; the immunosuppressants meridamycin and brasilicardin A; the anti-inflammatory agent cyclooctatin; and the acute iron poisoning medication desferrioxamine B. "
5.	Neoplasms (Cancer) 10/01/2013 - "Toxoflavin exhibited growth inhibition of various cancer cell lines including A549 lung cancer cells with a GI(50) of 48 nM. Toxoflavin treatment in A549 cells increased the acetylated form of p53, which is a substrate of SIRT1. "

Related Drugs and Biologics

1.	Anti-Bacterial Agents (Antibiotics)
2.	Sirtuin 1
3.	Pyocyanine
4.	Nigericin
5.	Kanamycin
6.	Iron
7.	Immunosuppressive Agents (Immunosuppressants)
8.	Deferoxamine (Desferal)
9.	Antineoplastic Agents (Antineoplastics)
10.	Antifungal Agents