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tolfenamic acid

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Also Known As:

Bifenac; Clotam; GEA 6414; N-(3-chloro-2-methylphenyl)anthranilic acid; N-(3-chloro-o-tolyl)anthranilic acid; Pharmacia brand of tolfenamic acid; Provalis brand of tolfenamic acid; Rociclyn; Zambon brand of tolfenamic acid

Networked: 93 relevant articles (14 outcomes, 28 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 58
- Carboxylic Acids: 83
  - Carbocyclic Acids
    - Benzoic Acids: 18
      - Aminobenzoic Acids
        Anthranilic Acids: 3
        tolfenamic acid: 93

Experts

1.	Basha, Riyaz: 12 articles (11/2015 - 01/2011)
2.	Safe, Stephen: 12 articles (02/2014 - 06/2006)
3.	Sankpal, Umesh T: 11 articles (11/2015 - 01/2011)
4.	Abdelrahim, Maen: 10 articles (11/2012 - 06/2006)
5.	Baker, Cheryl H: 7 articles (06/2012 - 06/2006)
6.	Zawia, Nasser H: 6 articles (04/2015 - 12/2011)
7.	Lee, Seong-Ho: 6 articles (01/2015 - 12/2008)
8.	Baek, Seung Joon: 6 articles (05/2014 - 12/2008)
9.	Maliakal, Pius: 6 articles (10/2013 - 01/2012)
10.	Eslin, Don: 5 articles (11/2015 - 01/2013)

Related Diseases

1.	Migraine Disorders (Migraine) 12/01/1982 - "Tolfenamic acid is a potent inhibitor of prostaglandin biosynthesis, which has been proved effective in the treatment of acute migraine attacks. " 04/01/1999 - "Tolfenamic acid is also effective in the acute treatment of migraine attacks. " 01/01/2015 - "Tolfenamic acid (TA) is a traditional non-steroid anti-inflammatory drug (NSAID) and has been broadly used for the treatment of migraines. " 01/01/2002 - "Because of its high efficacy, excellent tolerability and low cost, tolfenamic acid is an interesting option for migraine prophylaxis." 01/01/2002 - "[Effectiveness of tolfenamic acid in the prevention of migraine]."
2.	Neoplasms (Cancer) 07/01/2013 - "Furthermore, in vivo experiments showed that tolfenamic acid treatment resulted in a significant reduction in tumor volume over 5 weeks. " 10/01/2013 - "Recent studies demonstrate that tolfenamic acid (TA) induces apoptosis and suppresses the development and progression of several types of cancers. " 07/01/2013 - "Recent studies have indicated that non-steroidal anti-inflammatory drug (NSAID), particularly tolfenamic acid, can inhibit proliferation and induce apoptosis invarious cancer cells. " 03/01/2011 - "Earlier studies have shown that tolfenamic acid (Tol) exhibits anticancer activity in several cancer models by inhibiting tumor growth and angiogenesis. " 03/01/2009 - "In vivo studies show that tolfenamic acid enhanced the radiation-induced apoptosis associated with decreased survivin expression in tumors and this correlates with the enhanced response of these tumors to the radiation. "
3.	Pancreatic Neoplasms (Pancreatic Cancer) 03/01/2009 - "Radiation increased survivin promoter activity and protein expression in Panc1 and L3.6pl cells and tolfenamic acid inhibited both constitutive and radiation-induced survivin protein expression and enhanced the response of pancreatic cancer cells to radiation therapy. " 12/01/2008 - "Tolfenamic acid is a NSAID that exhibits anticancer activity in a pancreatic cancer model. " 06/21/2006 - "Tolfenamic acid and structurally related biaryl derivatives induced degradation of Sp1, Sp3, and Sp4 in pancreatic cancer cells. " 06/21/2006 - "Tolfenamic acid and pancreatic cancer growth, angiogenesis, and Sp protein degradation." 03/01/2009 - "In addition, an orthotopic model for human pancreatic cancer has been used to confirm the efficacy of tolfenamic acid to enhance tumor response to radiation in vivo. "
4.	Postoperative Pain 12/01/2007 - "Field evaluation of the efficacy of tolfenamic acid administered in one single preoperative injection for the prevention of postoperative pain in the dog." 12/01/2007 - "In this randomized, placebo-controlled, blinded field trial, 62 dogs (of which four were excluded) taken to a veterinary practice for orthopaedic surgery with a postoperative painful component were enrolled to assess the efficacy of a preoperative intramuscular injection of tolfenamic acid (TA) at a dose of 4 mg/kg in preventing postoperative pain. " 11/01/2008 - "Efficacy of tolfenamic acid and meloxicam in the control of postoperative pain following ovariohysterectomy in the cat."
5.	Pain (Aches) 08/01/2008 - "Effects of meloxicam or tolfenamic acid administration on the pain and stress responses of Merino lambs to mulesing." 05/01/1990 - "We found a significant superiority of tolfenamic acid over paracetamol with regard to effect on pain after 2 h (p less than 0.01), patients' global evaluation (p less than 0.001), and use of escape medication (p less than 0.02). " 04/01/1986 - "Tolfenamic acid, but not propranolol, significantly reduced the median intensity of pain and the number of attacks confining the patients to their beds when compared with placebo. " 10/01/1979 - " Pain symptoms occurred less often during tolfenamic acid and ASA than during placebo or indomethacin (P.05). " 02/01/1984 - "The greatest relief from pain was achieved by diclofenac, indomethacin, naproxen and tolfenamic acid, each of these being preferred by the majority of patients and being significantly (p less than 0.01) better than the least effective drugs ketoprofen and proquazone. "

Related Drugs and Biologics

1.	Indomethacin (Indometacin)
2.	Aspirin (Acetylsalicylic Acid)
3.	Sp Transcription Factors
4.	Prostaglandins
5.	Naproxen (Naprosyn)
6.	Mefenamic Acid (Pontal)
7.	Diclofenac (SR 38)
8.	Sumatriptan (Imigran)
9.	Plicamycin
10.	Curcumin

Related Therapies and Procedures

1.	Intramuscular Injections
2.	Heterologous Transplantation (Xenotransplantation)
3.	Radiotherapy
4.	Injections
5.	Oral Administration