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2-(4-toluidino)-6-naphthalenesulfonic acid (TNS)

Subscribe to New Research on 2-(4-toluidino)-6-naphthalenesulfonic acid

RN given refers to parent cpd; structure

Also Known As:

TNS; 2,6-TNS; 2-(4-toluidino)-6-naphthalenesulfonic acid, monopotassium salt; 2-p-toluidino-6-naphthalenesulfonic acid; 2-p-toluidinylnaphthalene-6-sulfonate; 6-p-toluidino-2-naphthalenesulfonic acid; 6-p-toluidinylnaphthalene-2-sulfonate; mansic acid; sodium mansate

Networked: 233 relevant articles (22 outcomes, 44 trials/studies)

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Bio-Agent Context: Research Results

Experts

1.	Cordeiro, Quirino: 7 articles (11/2015 - 03/2014)
2.	Shiozawa, Pedro: 7 articles (11/2015 - 03/2014)
3.	Cook, Ian A: 4 articles (11/2015 - 03/2015)
4.	Trevizol, Alisson Paulino: 4 articles (11/2015 - 05/2015)
5.	da Silva, Mailu Enokibara: 3 articles (05/2015 - 03/2014)
6.	Kopacz, Dan J: 3 articles (02/2005 - 01/2004)
7.	Barros, Mirna Duarte: 2 articles (11/2015 - 09/2015)
8.	Puett, David: 2 articles (11/2015 - 06/2013)
9.	Azizi, Ghobad: 2 articles (11/2015 - 06/2013)
10.	Sato, Isa Albuquerque: 2 articles (09/2015 - 05/2015)

Related Diseases

1.	Pain (Aches) 03/01/1979 - "Most importantly, these results support the efficacy of TNS for the treatment of clinical pain." 12/01/1978 - "57 (55.9%) of 102 women treated considered TNS had given them good or very good relief from pain; 24 (23.5%) reported that they had received some relief, while 21 patients (20.6%) were of the opinion that they were not helped by the technique. " 11/01/1990 - "None of the parameters except functional pain, which improved significantly more after high frequency TNS than placebo TNS, revealed any difference between the methods. " 01/01/1978 - "High intensity TNS near the painful joint gave pain relief of varying degree in 95% of the patients, while TNS of low intensity and TNS applied at a remote site gave an improvement in 75% and 5% respectively. " 01/01/1985 - "A prospective study of the use of transcutaneous neural stimulation (TNS) in 90 arthroscopic knee surgery patients was performed to determine: if TNS is as effective as traditional pain medication in treating postoperative knee pain; and if patients that had received TNS regain preoperative motion and strength quicker than the control population. "
2.	Neoplasm Metastasis (Metastasis) 10/01/1985 - "The above results confirm that TNS is extremely effective in preventing metastasis." 12/01/2001 - "TNs > 3 mm should be considered the prognostic equivalent of lymph node metastases as recommended by the 1997 TNM classification. " 10/01/1985 - "2) TNS showed a 60% inhibitory effect on spontaneous metastasis, and the weight of the original tumor regressed by 60%. " 12/01/2001 - "The aim of the present study was to evaluate, in a series of 166 stage II and stage III colorectal adenocarcinomas, the following pathologic parameters: number of lymph nodes recovered and examined, number of lymph nodes with metastases, and number of tumor nodules (TNs) in the perirectal or pericolic adipose tissue greater or smaller than 3 mm in diameter (TNs > 3 mm and TNs < 3 mm, respectively). " 06/01/2007 - "The aim of the study was to evaluate the usefulness of calcitonin (CT) assay in fine-needle aspiration biopsy (FNAB) wash-out fluid alone or combined with cytology in the presurgical study of medullary thyroid carcinoma (MTC) patients with thyroid nodules (TNs) and of suspicious neck MTC recurrences/metastases. "
3.	Ulcer 01/01/1988 - "The study demonstrates a clear therapeutic effect for low-frequency TNS in patients with leprous ulcers. " 01/01/1988 - "The present report describes a similar study, using TNS treatment in attempts to accelerate healing of chronic leprous ulcers that had resisted treatment for several months or years. " 01/01/1988 - "In 19 patients (6 out- and 13 in-patients), in whom the TNS treatment was not interrupted, all ulcers healed completely within a mean of 5.2 weeks (range 3-12 weeks). " 01/01/2012 - "Macroscopically, the ulcer control group exhibited severe mucosal injury, whereas pre-treatment with either cimetidine or TNS and its nickel (II) complex each resulted in significant protection against gastric mucosal injury. " 01/01/2012 - "Histological studies of the gastric wall of ulcer control group revealed severe damage of gastric mucosa, along with edema and leucocytes infiltration of the submucosal layer compared to rats pre-treated with either cimetidine or TNS and its nickel (II) compound, where there was marked gastric protection along with reduction of edema and leucocytes infiltration of the submucosal layer. "
4.	Diabetic Neuropathies (Diabetic Neuropathy) 11/10/1999 - "The authors measured the inter- and intrarater reliability of the TNS and preformed a cross-sectional validation study of the TNS and its subscales with the Mayo Clinic measures of neuropathy, neuropathy symptom score (NSS), and the neurologic impairment score (NIS) in five healthy control subjects and 30 individuals with varying severities of diabetic polyneuropathy. " 11/10/1999 - "To determine the validity and reliability of the total neuropathy score (TNS) in normal subjects and in subjects with diabetic polyneuropathy. " 01/01/1984 - "Transcutaneous nerve stimulation (TNS) has previously been shown to improve microcirculation in ischemic limbs of patients with Raynaud's phenomenon and diabetic neuropathy and to accelerate healing of chronic skin ulcerations. " 01/01/1983 - "Low-frequency transcutaneous nerve stimulation (TNS) produces marked and widespread increases in skin temperature in ischaemic limbs of patients with Raynaud's disease and diabetic polyneuropathy. " 01/01/1983 - "The serotonin receptor antagonist cyproheptadine was given to 4 patients with either Raynaud's phenomenon or diabetic polyneuropathy, who all prior to drug administration responded to TNS with marked and prolonged cutaneous vasodilation in the ischaemic limbs. "
5.	Overactive Urinary Bladder (Overactive Bladder) 09/01/2013 - "Although urodynamics and symptoms scores did not show significant difference, an efficacy of TNS on overactive bladder in PD and MSA is possible. " 06/15/2012 - "TNS is a minimally invasive treatment for overactive bladder (OAB), but its efficacy is low. " 08/01/2015 - "Results of this and previous studies indicate 1) forebrain circuitry rostral to the pons is not essential for TNS inhibition; and 2) opioid receptors in the brain stem have a critical role in TNS inhibition of overactive bladder reflexes but are not involved in inhibition of normal bladder reflexes. " 09/01/2013 - "To evaluate the efficacy of chronic transcutaneous tibial nerve stimulation (TNS) on overactive bladder syndrome in female patients with Parkinson's disease (PD) and multiple system atrophy (MSA). "

Related Drugs and Biologics

1.	salicylhydroxamic acid (SHAM)
2.	Cimetidine (Biomet)
3.	terbinafine (Lamisil)
4.	Nickel
5.	dodecyl 2-(N,N-dimethylamino)propionate
6.	Mepivacaine (Carbocaine)
7.	Tobramycin (Nebcin)
8.	Colistin (Coly-Mycin)
9.	Lidocaine (Xylocaine)
10.	Lactic Acid

Related Therapies and Procedures

1.	Transcutaneous Electric Nerve Stimulation (TENS)
2.	Spinal Anesthesia
3.	Splints
4.	Thoracotomy
5.	Analgesia