tingenone

quinonoid triterpene isolated from Euonymus tingens

Also Known As:

(6bS,8aS,11R,12aR,12bS,14aR)-3-Hydroxy-4,6b,8a,11,12b,14a-hexamethyl-7,8,8a,11,12,12a,12b,13,14,14a-decahydro-2,10(6bH,9H)-picenedione; 20-decarboxy-20-oxocelastrol; maitenin; maitenine; maytenin; tingenin A; tingenon

Networked: 8 relevant articles (1 outcomes, 4 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Terpenes: 1461
    - Triterpenes: 2493
      - Pentacyclic Triterpenes: 108
        tingenone: 8

Experts

1.	Duarte, Igor Dimitri: 2 articles (05/2015 - 11/2014)
2.	Duarte, Lucienir Pains: 2 articles (05/2015 - 11/2014)
3.	Ferreira, Renata Cristina Mendes: 2 articles (05/2015 - 11/2014)
4.	Klein, Andre: 2 articles (05/2015 - 11/2014)
5.	Rodrigues, Vanessa Gregório: 2 articles (05/2015 - 11/2014)
6.	Romero, Thiago Roberto Lima: 2 articles (05/2015 - 11/2014)
7.	Motaung, Keolebogile Shirley: 1 article (05/2022)
8.	Razwinani, Mapula: 1 article (05/2022)
9.	Bezerra, Daniel P: 1 article (10/2021)
10.	Bomfim, Larissa M: 1 article (10/2021)

Related Diseases

1.	Chagas Disease (American Trypanosomiasis) 01/01/1999 - "cruzi and in experimental Chagas disease (murine model): alkyllysophospholipids; 5-amino-imidazole-4-carboxamides; bisbenzyl-isoquinolines; cruzipain (crucein) inhibitors; Gossipol; phenothiazines; d) drugs effective in vitro without other reported effects, acridines, actinomycin D, Crystal Violet (gentian violet), diterpenes (Mikania obtusata); N,N'-dimethyl-2-propen-1-amine, epoxidienthiol carbamates, Fe-chelators, guanyl hydrazones, o-naphthoquinones (beta-lapachone); quinoids (miconidine; tingenone); Olivacine, phenazine methosulfate, phenoxi-phenoxyl drugs, Proadifen, pyridinium azolate betaines, sesquiterpenes (Lychophora sp), sesquiterpene lactones, tetrahydrocarbazoles, DL-alpha-trifluoromethylarginine, triphenylmetane dyes. "
2.	Hyperalgesia 11/01/2014 - "The present study assessed the involvement of the opiodergic pathway in the tingenone-induced antinociceptive effect against hyperalgesia induced by prostaglandin E2 (2 µg) in the peripheral pathway. " 02/01/2018 - "The aim of this study was to assess the involvement of the cannabinoid system in the antinociceptive effect induced by tingenone against hyperalgesia evoked by prostaglandin E2 (PGE2) at peripheral level. " 05/15/2015 - "The study assessed the involvement of L-arginine/NO/cGMP/KATP pathway in the antinociceptive effect induced by tingenone, from Maytenus imbricata, against the hyperalgesia evoked by prostaglandin E2 (PGE2) in peripheral pathway. "
3.	Hypertrophy 05/01/2022 - "The study investigated the influence of friedelin, resinone, tingenone and betulin plant-based secondary metabolite compounds on cellular proliferation, extracellular matrix (ECM) components synthesis, expression of chondrogenic markers and maturation of differentiated chondrocytes (cell proliferation and hypertrophy) in porcine adipose-derived mesenchymal stem cells (pADMSCs) undergoing chondrogenic differentiation. "
4.	Neoplasms (Cancer) 02/10/2020 - "Intraperitoneal administration of maytenin to tumor-bearing mice did not lead to pronounced histopathological changes in kidney tissue, suggesting low nephrotoxicity. " 02/10/2020 - "Additionally, we investigated the toxicity of maytenin in SCID mice harboring tumors derived from a squamous cell carcinoma cell line. " 10/01/2021 - "Tingenone (TG) and 22-hydroxytingenone (22-HTG) are quinonemethide triterpenes found in the Amazonian plant Salacia impressifolia (Celastraceae), with cytotoxic properties in different histological types of cancer cells. "
5.	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 10/01/2021 - "Tingenone and 22-hydroxytingenone target oxidative stress through downregulation of thioredoxin, leading to DNA double-strand break and JNK/p38-mediated apoptosis in acute myeloid leukemia HL-60 cells."

Related Drugs and Biologics

1.	Sesquiterpenes
2.	Proadifen
3.	Phenothiazines
4.	Naphthoquinones
5.	Methylphenazonium Methosulfate
6.	Lactones
7.	Isoquinolines
8.	Hydrazones
9.	Gentian Violet (Violet, Crystal)
10.	Coloring Agents (Dyes)