beta-thujaplicin

09/29/2017 - "Previous studies reported that hinokitiol exhibits an anti-cancer activity against murine tumor cells through the induction of autophagy. "
01/01/2013 - "This study demonstrates for the first time that in addition to being originally considered as an agent against microbes and variety of cancers, hinokitiol possesses potent neuroprotective activity. "
01/01/2023 - "Administration of hinokitiol, a potential UHRF1 inhibitor, significantly reduced tumor growth and CSC phenotypes in mice with Myc-driven HCC. "
01/31/2022 - "In U-2 OS cells with wild-type tumor suppressor p53, we found that hinokitiol exposure induced p53 expression and cellular senescence, and knockdown of p53 suppressed the senescence. "
01/01/2022 - "Our results showed that hinokitiol can chemosensitize cancer cells. "

04/01/2006 - "These results suggest that beta-thujaplicin eardrops are effective for Malassezia-related otitis externa in dogs."
12/01/2005 - "Effects of beta-thujaplicin on anti-Malassezia pachydermatis remedy for canine otitis externa."
12/01/2005 - "The antifungal activity of beta-thujaplicin was evaluated against 51 Malassezia pachydermatis strains isolated from canine ear canals with or without otitis externa. "
12/01/2005 - "The MIC50 of beta-thujaplicin did not change during the course of subculture, and it is thought that the potential development of a resistant strain is low, even with continuous infusion for otitis externa therapy. "
12/01/2005 - "beta-Thujaplicin is an inexpensive and safe treatment with anti-inflammatory and deodorant effects that can be recommended as an effective remedy for canine otitis externa."

01/01/2022 - "Hinokitiol affected the ER homeostasis as well as degradation of TYR and MITF in two human melanoma cell lines, G361 and HT-144, but the changes of ER-stress markers under the hinokitiol treatment were different in the two human melanoma cell lines. "
01/01/2019 - "Hinokitiol can be useful for developing therapeutic agent for melanoma."
01/01/2019 - "Exposure of the melanoma B16-F10 cells to hinokitiol significantly inhibited colony formation and cell viability in a time and concentration-dependent manner. "
01/01/2019 - "We investigated the potential anticancer effects of hinokitiol in metastatic melanoma cell line B16-F10. "
02/18/2016 - "Hinokitiol Inhibits Melanogenesis via AKT/mTOR Signaling in B16F10 Mouse Melanoma Cells."

01/01/2020 - "In this study, the efficacy of hinokitiol was investigated in a mouse pneumonia model. "
01/01/2020 - "These findings suggest that hinokitiol reduced bacterial load and suppressed excessive host immune response in the pneumonia mouse model. "
01/01/2020 - "Treatment of severe pneumonia by hinokitiol in a murine antimicrobial-resistant pneumococcal pneumonia model."

08/01/2022 - "In conclusion, the results of the present study demonstrate that hinokitiol has significant potential to prevent cerulein-induced acute pancreatitis."
08/01/2022 - "This study was conducted to evaluate the ameliorative effects of hinokitiol against acute pancreatitis induced by cerulein. "
08/01/2022 - "Tropolone derivative hinokitiol ameliorates cerulein-induced acute pancreatitis in mice."
08/01/2022 - "The immunohistochemical expression of nuclear factor kappa light chain enhancer of activated B cells (NF-κB), cyclooxygenase (COX-2) and TNF-α were significantly decreased by hinokitiol in mice with cerulein-induced acute pancreatitis. "
08/01/2022 - "Furthermore, hinokitiol administration significantly reduced the pancreatitis-evoked decrease in the activity of catalase, glutathione (GSH) and superoxide dismutase (SOD) in the pancreatic tissue. "