tetrahydrodeoxycorticosterone

RN given refers to (3alpha,5beta)-isomer

Also Known As:

3 alpha,21-dihydroxy-5 beta-pregnan-20-one; 3 alpha,5 beta-tetrahydrodeoxycorticosterone; 3 beta,5 alpha-tetrahydrodeoxycorticosterone; 3,21-dihydroxypregnan-20-one; 3alpha,21-dihydroxy-5alpha-pregnan-20-one; 5alpha-THDOC; 5alpha-pregnan-3alpha,21-diol-20-one; 5alpha-pregnane-3alpha,21-diol-20-one; THDOC; allotetrahydrodeoxycorticosterone; pregnane-3,21-diol-20-one; tetrahydrodeoxycorticosterone, (3alpha,5alpha)-isomer; tetrahydrodeoxycorticosterone, (3beta,5alpha)-isomer; tetrahydrodesoxycorticosterone

Networked: 34 relevant articles (2 outcomes, 5 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Biggio, Giovanni: 4 articles (07/2008 - 05/2003)
2.	Reddy, Doodipala Samba: 2 articles (02/2013 - 01/2003)
3.	Rogawski, Michael A: 2 articles (07/2011 - 05/2002)
4.	Concas, Alessandra: 2 articles (07/2008 - 05/2006)
5.	Sogliano, Cristiana: 2 articles (07/2008 - 05/2006)
6.	Serra, Mariangela: 2 articles (08/2004 - 05/2003)
7.	Bose, Sarpita: 1 article (01/2021)
8.	Chakrabarti, Saikat: 1 article (01/2021)
9.	Kumar, Krishna: 1 article (01/2021)
10.	Chrościńska-Krawczyk, Magdalena: 1 article (01/2020)

Related Diseases

1.	Seizures (Absence Seizure) 03/01/2018 - "No difference between the efficacy of THPROG and THDOC on absence seizures in WAG/Rij rats was observed." 05/01/2002 - "DOC also elevated plasma THDOC levels and protected mice against PTZ, methyl-6,7-dimethoxy-4-ethyl-beta-carboline-3-carboxylate, picrotoxin, and amygdala-kindled seizures in mice (ED50 values, 84-97 mg/kg). " 07/01/2011 - "Because THDOC is a potent anticonvulsant, it is plausible that CYP11B1 inhibitors could protect against seizures. " 10/16/1998 - "However, alphaxalone and tetrahydrodeoxycorticosterone failed to potentiate gamma-hydroxybutyric acid-induced absence seizures when injected into thalamic reticular nucleus. " 10/16/1998 - "In the present study, the effect of two synthetic neuroactive steroids, alphaxalone (5alpha-pregnane 3alpha-ol-11, 20-dione) and tetrahydrodeoxycorticosterone was studied in a rat model of generalized absence seizures induced by gamma-hydroxybutyric acid. "
2.	Lordosis 11/01/1999 - "3alpha,5alpha-THP and THDOC implants to the VTA were the most effective at immediately facilitating lordosis of rats and hamsters. " 11/01/1999 - "Two hours later all other progestins, except MA and CA, increased lordosis in rats; only P, 3alpha,5alpha-THP, and THDOC were effective in hamsters. " 11/01/1999 - "The progestins' effectiveness at facilitating lordosis were similar to their effects on GABA-stimulated chloride influx and SR 95531 receptor binding (3alpha,5alpha-THP and THDOC>P>DHP>3alpha, 5beta-THP>MA and CA). "
3.	Pain (Aches) 12/01/2001 - "The present study investigates the effects of a neurosteroid tetrahydrodeoxycorticosterone (5alpha-pregnan-3alpha-21-diol-20-one) in two experimental models of pain sensitivity in mice. " 07/01/2010 - "Results suggest that progesterone and its neurosteroid metabolites may be crucial to the development of pelvic visceral neuropathic/postinflammatory pain and imply clinical use of neurosteroids, such as allopregnanolone and THDOC, for visceral pain treatment."
4.	Schizophrenia (Dementia Praecox) 08/01/2004 - "Long-term treatment with clozapine does not affect morning circulating levels of allopregnanolone and THDOC in patients with schizophrenia: a preliminary study."
5.	Absence Epilepsy (Childhood Absence Epilepsy) 03/01/2018 - "In this study, we compared the effects of endogenous steroids (THPROG and THDOC) on SWD by using finasteride-treated Wistar Albino Glaxo from Rijswijk (WAG/Rij) rats as a model of absence epilepsy. "

Related Drugs and Biologics

1.	Progestins (Progestagens)
2.	Neurosteroids
3.	Pregnanolone (Allopregnanolone)
4.	tetrahydrodeoxycorticosterone
5.	Steroids
6.	GABA-A Receptors (GABA(A) Receptor)
7.	Dehydroepiandrosterone (DHEA)
8.	pregnenolone sulfate
9.	Finasteride (Propecia)
10.	Clozapine (Clozaril)

Related Therapies and Procedures

1.	Intraperitoneal Injections
2.	Therapeutics
3.	Analgesia