HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

sulfoevernan

inhibitor of cyclo-AMP phosphodiesterase

Also Known As:

sulphoevernan

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Macromolecular Substances: 97
- Polymers: 13051
  - Biopolymers: 773
    - Glucans: 1624
      - sulfoevernan: 2
Carbohydrates: 22023
- Polysaccharides: 15383
  - Glucans: 1624
    - sulfoevernan: 2

Related Diseases

1.	Infections 01/01/1991 - "In addition, we show that infection of CEM cells by HIV-1 from bone of an AIDS patient in vitro can be blocked by Sulfoevernan, a compound recently discovered by our group." 09/01/1990 - "This compound effectively inhibits both human immunodeficiency virus type 1 (HIV-1) and type 2 infection of cells in vitro at concentrations around 0.5 micrograms/ml. Moreover, the compound completely inhibits HIV-1-induced syncytium formation at a concentration of 1 microgram/ml. Competition experiments with 35S-labelled sulphoevernan revealed that the mannose-specific lectin from Narcissus pseudonarcissus prevented binding of sulphoevernan to HIV-1, whereas the antibody OKT4A did not reduce the amount of sulphoevernan bound to MT-2 cells. " 09/01/1990 - "Sulphoevernan, a polyanionic polysaccharide, and the narcissus lectin potently inhibit human immunodeficiency virus infection by binding to viral envelope protein."
2.	Acquired Immunodeficiency Syndrome (AIDS) 09/01/1990 - "From these in vitro and in vivo data we conclude that sulphoevernan has potential in the treatment of acquired immunodeficiency syndrome." 01/01/1991 - "In addition, we show that infection of CEM cells by HIV-1 from bone of an AIDS patient in vitro can be blocked by Sulfoevernan, a compound recently discovered by our group."

Related Drugs and Biologics

1.	Mannose-Binding Lectins
2.	Viral Envelope Proteins
3.	Polysaccharides (Glycans)
4.	OKT4A monoclonal antibody
5.	narcissus lectin