succinic semialdehyde

01/01/1975 - "Mechanism of the protective effect of succinic semialdehyde and its derivatives in hypoxia."
07/01/1974 - "[Mechanism of the protective effec of succinic semialdehyde and its derivatives in hypoxia]."
05/01/1976 - "[Effect of succinic semialdehyde on nitrogen metabolism of animal brain tissue during hypoxia]."
01/01/1975 - "Preliminary injection of succinic semialdehyde into animals in experiments with hypoxia led to a lower concentration of free ammonia in their brain tissues than in control experiments in which the compound was not given. "
03/01/2003 - "Although the modern concept of neuroprotection has been formulated quite recently, the basis of this approach was laid about four decades ago when Zakusov initiated the study of mechanisms involved in the neuroprotector action of GABA shunt metabolites (in particular, alpha-hydroxybutyric acid and succinic semialdehyde) during hypoxia. "

10/01/2017 - "SSADH deficiency in an Italian family: a novel ALDH5A1 gene mutation affecting the succinic semialdehyde substrate binding site."
01/01/2005 - "Succinic semialdehyde (SSA) accumulates in the inborn error of meta- bolism succinic semialdehyde dehydrogenase deficiency owing to impaired enzymatic conversion to succinic acid. "
10/01/1988 - "Oxidation of [U-14C]succinic semialdehyde in cultured human lymphoblasts: measurement of residual succinic semialdehyde dehydrogenase activity in 11 patients with 4-hydroxybutyric aciduria."
01/01/2005 - "Determination of the GABA analogue succinic semialdehyde in urine and cerebrospinal fluid by dinitrophenylhydrazine derivatization and liquid chromatography-tandem mass spectrometry: application to SSADH deficiency."
09/01/1984 - "A coupled assay using [14C]4-aminobutyric acid and a direct assay using [14C]succinic semialdehyde have been designed to assay te activity of succinic semialdehyde dehydrogenase in a patient with 4-hydroxybutyric aciduria and family members. "

05/01/1986 - "Uptake of labelled dopamine and GABA and activities of GABA transaminase, dehydrogenase and reductase of succinic semialdehyde were studied in brain of rats with different duration of ethanol narcosis. "

06/01/1954 - "Restoration of acetoin and succinic semialdehyde formation in pigeon muscle homogenates impaired by thiamine deficiency."

08/04/2023 - "Our data also indicated that succinic semialdehyde dehydrogenase, an enzyme involved in the shunt of the tricarboxylic acid (TCA) cycle to generate succinic acid, was decreased upon infection, suggesting that infection may trigger the accumulation of succinic semialdehyde, causing the production of GHB. "