saccharolactone

used as index for assessing induction of hepatic enzymes by anticonvulsants; RN given refers to cpd without isomeric designation

Also Known As:

1,4-D-glucarolactone; 1,4-glucarolactone; D-glucaro-1,4-lactone; SACCHAROLACTONE, D-; saccharolactone, (D)-isomer; saccharolactone, monocalcium salt, (D)-isomer; saccharolactone, monosodium salt, (D)-isomer

Networked: 5 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Hanausek, Margaret: 2 articles (09/2011 - 09/2008)
2.	Slaga, Thomas J: 2 articles (09/2011 - 09/2008)
3.	Walaszek, Zbigniew: 2 articles (09/2011 - 09/2008)
4.	Yoshimi, Naoki: 2 articles (09/2011 - 09/2008)
5.	Liu, Aihong: 1 article (12/2018)
6.	Sun, Shuilin: 1 article (12/2018)
7.	Xie, Baogang: 1 article (12/2018)
8.	Yang, Wenlong: 1 article (12/2018)
9.	Yang, Wentao: 1 article (12/2018)
10.	Zhou, Guanlin: 1 article (12/2018)

Related Diseases

1.	Carcinogenesis 09/01/2008 - "Our previous studies have shown that the β-glucuronidase inhibitor D-glucaro-1,4-lactone, an active metabolite of D-glucaric acid, inhibits chemically-induced tumorigenesis in rodents. " 09/01/2011 - "Therefore, the primary goal of this study was to demonstrate that exposing the skin of SENCAR mice to the natural βG inhibitor D-glucaro-1,4-lactone (1,4-GL) and its precursor D-glucuronic acid-γ-lactone (GUL), prior to and during 7,12-dimethylbenz[α]anthracene (DMBA) treatment inhibits not only epidermal hyperplasia but also inflammation in the mouse skin complete carcinogenesis model, i.e., the 4-week inflammatory-hyperplasia assay. "
2.	Inflammation (Inflammations) 09/01/2011 - "Therefore, the primary goal of this study was to demonstrate that exposing the skin of SENCAR mice to the natural βG inhibitor D-glucaro-1,4-lactone (1,4-GL) and its precursor D-glucuronic acid-γ-lactone (GUL), prior to and during 7,12-dimethylbenz[α]anthracene (DMBA) treatment inhibits not only epidermal hyperplasia but also inflammation in the mouse skin complete carcinogenesis model, i.e., the 4-week inflammatory-hyperplasia assay. "
3.	Hyperplasia 09/01/2011 - "Therefore, the primary goal of this study was to demonstrate that exposing the skin of SENCAR mice to the natural βG inhibitor D-glucaro-1,4-lactone (1,4-GL) and its precursor D-glucuronic acid-γ-lactone (GUL), prior to and during 7,12-dimethylbenz[α]anthracene (DMBA) treatment inhibits not only epidermal hyperplasia but also inflammation in the mouse skin complete carcinogenesis model, i.e., the 4-week inflammatory-hyperplasia assay. "
4.	Gallstones (Gallstone) 04/01/1989 - "This experiment was designed to test the hypothesis that orally administered D-glucaro-1,4-lactone might be excreted in the bile and thus suppress the activity of biliary beta-glucuronidase, which is believed to play a key role in the development of pigment gallstones. "
5.	Neoplasms (Cancer) 12/01/1957 - "Enzyme activity in relation to cancer: inhibition of urinary beta-glucuronidase of patients with cancer of the bladder by oral administration of 1:4-saccharolactone and related compounds."

Related Drugs and Biologics

1.	Glucuronidase
2.	Glucuronic Acid (Glucuronate)
3.	Lactones
4.	Glucaric Acid
5.	anthracene
6.	Enzymes
7.	Diethylnitrosamine (N-Nitrosodiethylamine)

Related Therapies and Procedures

1.	Oral Administration