protoberberine

a benzyltetrahydroisoquinoline derivative that appears as an isoquinoline annelated (adjoined) with a naphthylene; the nitrogen is typically quarternary; nitidine is annelated differently; RN given refers to parent cpd

Also Known As:

Networked: 38 relevant articles (3 outcomes, 10 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Bandyopadhyay, Sandip K: 2 articles (04/2018 - 07/2017)
2.	Bhattacharyya, Rahul: 2 articles (04/2018 - 07/2017)
3.	Chattopadhyay, Subrata: 2 articles (04/2018 - 07/2017)
4.	Patro, Birija Sankar: 2 articles (04/2018 - 07/2017)
5.	El-Readi, Mahmoud Zaki: 2 articles (02/2013 - 01/2012)
6.	Wink, Michael: 2 articles (02/2013 - 01/2012)
7.	Nyasse, B: 2 articles (06/2002 - 07/2000)
8.	Tan, P V: 2 articles (06/2002 - 07/2000)
9.	Wafo, P: 2 articles (06/2002 - 07/2000)
10.	LaVoie, E J: 2 articles (06/2000 - 05/2000)

Related Diseases

1.	Neoplasms (Cancer) 01/29/2010 - "We screened a protoberberine backbone derivative library for compounds with anti-proliferative effects on p53-defective cancer cells. " 08/01/2003 - "Previous studies on the anticancer activity of protoberberine alkaloids against a variety of cancer cell lines were extended to human tumour HeLa and murine leukemia L1210 cell lines. " 04/01/2018 - "Coralyne, a protoberberine alkaloid, causes robust photosenstization of cancer cells through ATR-p38 MAPK-BAX and JAK2-STAT1-BAX pathways." 07/01/2001 - "In vitro cytotoxic activities of 24 quaternary protoberberine alkaloids related to berberine have been evaluated using a human cancer cell line panel coupled with a drug sensitivity database. " 07/01/2004 - "Previous studies on anti-cancer activity of protoberberine alkaloids against a variety of cancer cell lines were extended to human uterus HeLa nad murine leukemia L1210 cell lines. "
2.	Malaria 01/30/2024 - "The protoberberine alkaloids isolated have been identified as fast-acting antiplasmodial agents, with activity against all erythrocytic stages of the malaria parasite. " 01/30/2024 - "Between berberine and palmatine isolated from the potent fractions, only the former showed ∼100% and 90% inhibitions of liver stage parasite at 5 μg/ml and 1 μg/ml, respectively, while the latter showed no inhibition even at 20 μg/ml. This study reports that the ethnomedicinal use of HHA to manage malaria can be attributed to the presence of promising antiplasmodial protoberberine alkaloids together with synergistic effects via either enhancement of bioavailability or improved pharmacokinetics by other phytoconstituent(s) coming from other HHA constituent plants. " 01/30/2024 - "Annickia affinis methanol extract, fractions, and the isolated protoberberine alkaloids showed excellent antiplasmodial activity with good selectivity against blood-stage malaria parasite. " 01/30/2024 - "affinis methanol stembark extract and the protoberberine alkaloid berberine isolated from it also displayed excellent activity (>90% inhibition at 1 μg/ml) against the liver-stage malaria parasite. "
3.	Hyperlipidemias (Hyperlipidemia) 01/01/2016 - "Protoberberine alkaloids are effective in modulating hyperglycemia and hyperlipidemia. " 01/01/2016 - "The present study is focused on the assessment of the antihyperglycemia and antidiabetic hyperlipidemia effect of five protoberberine alkaloids, berberine (BBR), coptisine (COP), palmatine (PAL), epiberberine (EPI), and jatrorrhizine (JAT), separated from R. "
4.	Hyperglycemia 01/01/2016 - "Protoberberine alkaloids are effective in modulating hyperglycemia and hyperlipidemia. "
5.	Leukemia L1210 08/01/2003 - "Previous studies on the anticancer activity of protoberberine alkaloids against a variety of cancer cell lines were extended to human tumour HeLa and murine leukemia L1210 cell lines. " 07/01/2004 - "Previous studies on anti-cancer activity of protoberberine alkaloids against a variety of cancer cell lines were extended to human uterus HeLa nad murine leukemia L1210 cell lines. "

Related Drugs and Biologics

1.	Alkaloids
2.	Berberine
3.	palmatine
4.	coralyne
5.	jatrorrhizine
6.	Poisons
7.	coptisine
8.	Benzylisoquinolines
9.	Berberine Alkaloids
10.	chelidonine