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pirprofen
Subscribe to New Research on pirprofen
anti-inflammatory agent used in therapy of rheumatoid arthritis; prostaglandin synthetase inhibitor; more potent than indomethacin; structure
Also Known As:
2-(3-chloro-4-(3-pyrroli-1-yl)phenyl)propionic acid; Rengasil; SU-21524
Networked:
73
relevant articles (
6
outcomes,
28
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Organic Chemicals: 58
Carboxylic Acids: 83
Carbocyclic Acids
Phenylpropionates
pirprofen: 73
Related Diseases
1.
Pain (Aches)
09/01/1988 - "
Pain relief after a single dose and reduction of the attack intensity occurred most often with pirprofen in patients who needed more than one dose.
"
12/01/1986 - "
However, as no one agent is the most suitable drug for all patients requiring such therapy, pirprofen may be considered along with other drugs of this type in the therapy of arthritic conditions and acute pain states.
"
01/01/1980 - "
Non-steroidal anti-inflammatory drug (Rengasil) in post extraction pain control.
"
08/28/1982 - "
In this multicentre, double-blind clinical study, the pain-relieving effects of single doses of pirprofen (200 and 400 mg) and pentazocin (100 mg) were compared with those of a placebo in 210 patients after oral surgery.
"
01/01/1989 - "
Pirprofen significantly reduced the duration of headache attack and associated symptoms, but not the peak of pain intensity.
"
2.
Rheumatoid Arthritis
08/28/1982 - "
One hundred ninety-five patients suffering from active rheumatoid arthritis were included in a two-week double blind multicentric study, whose purpose was to compare the efficacy and tolerance of a daily dose of 600 mg of pirprofen to that of 1200 mg and the placebo.
"
07/01/1974 - "
Tolerance to pirprofen and preliminary efficacy trial in rheumatoid arthritis.
"
10/01/1984 - "
[Double-blind clinical trial of pirprofen in patients with rheumatoid arthritis].
"
08/28/1982 - "
[Pirprofen in the treatment of rheumatoid arthritis].
"
08/28/1982 - "
[Treatment of rheumatoid arthritis with pirprofen.
"
3.
Osteoarthritis
10/15/1986 - "
[Pirprofen in the treatment of exacerbated osteoarthrosis in the aged.
"
08/28/1982 - "
Pirprofen is thus judged an effective drug for the treatment of osteoarthritis of the spine.
"
08/28/1982 - "
In addition, pirprofen seems able to slow down the evolution of certain experimental models of osteoarthritis.
"
01/01/1978 - "
Effect of C 21 524-Su (pirprofen) on spontaneous osteoarthrosis in the mouse.
"
01/01/1987 - "
A double-blind, double-dummy study design was used to compare the efficacy and tolerance of naproxen with that of pirprofen in the treatment of osteoarthritis.
"
4.
Connective Tissue Diseases (Connective Tissue Disease)
05/01/1989 - "
The dynamics of the change in the activity of enzymes of pentose phosphate pathway in the blood of patients with systemic connective tissue diseases against the background of treatment with roxicam, rengasil and flugalin is the enzymological criterion in assessing efficacy of pharmacological correction of the inflammatory process in the diseases.
"
5.
Rheumatic Diseases (Rheumatism)
10/01/1988 - "
Pirprofen in treatment of non-articular rheumatism in Pakistani outpatients, a multicentre study.
"
08/28/1982 - "
[Treatment of extra-articular rheumatism with pirprofen].
"
07/01/1986 - "
Four treatments for soft-tissue rheumatism--sham ionisation, placebo ionisation, and pharmacological ionisation with pirprofen (two-dose levels)--were assessed in a randomized double-blind, between-patient controlled trial in 73 outpatients affected by scapulo-humeral periarthritis or elbow epicondylitis.
"
01/01/1988 - "
A double-blind study was designed to compare the efficacy and tolerability of pirprofen and lysine soluble aspirin administered by iontophoresis to 80 patients with various painful rheumatic diseases.
"
01/01/1988 - "
Iontophoretic administration of pirprofen or lysine soluble aspirin in the treatment of rheumatic diseases.
"
Related Drugs and Biologics
1.
Aspirin (Acetylsalicylic Acid)
2.
pirprofen
3.
Naproxen (Naprosyn)
4.
Indomethacin (Indometacin)
5.
Flurbiprofen (Froben)
6.
Sodium
7.
Enzymes
8.
Ketoprofen (Orudis)
9.
Piroxicam (Feldene)
10.
Ibuprofen (Motrin)
Related Therapies and Procedures
1.
Oral Surgery (Maxillofacial Surgery)
2.
Drug Therapy (Chemotherapy)