piperine

Antineoplastic Agent, Phytogenic; RN given refers to cpd without isomeric designation; structure; more potent than vanilloid (capsaicin) at human TRPV1; used to increase gastrointestinal assimilation of other agents

Also Known As:

Networked: 186 relevant articles (21 outcomes, 46 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Hoskin, David W: 5 articles (10/2015 - 01/2013)
2.	Doucette, Carolyn D: 5 articles (10/2015 - 01/2013)
3.	Sakthisekaran, D: 5 articles (01/2006 - 02/2003)
4.	Selvendiran, K: 5 articles (01/2006 - 02/2003)
5.	Dhawan, D K: 4 articles (01/2013 - 11/2011)
6.	Pan, Hao: 3 articles (10/2015 - 10/2013)
7.	Yaffe, Paul B: 3 articles (10/2015 - 02/2013)
8.	Park, Taesun: 3 articles (12/2013 - 04/2012)
9.	Sehgal, A: 3 articles (01/2013 - 11/2011)
10.	Jain, M: 3 articles (01/2013 - 11/2011)

Related Diseases

1.	Inflammation 12/01/2015 - "Histological staining showed that piperine significantly reduced the infiltration of inflammation in soft tissues. " 07/01/2015 - "These results establish that piperine may contribute to prevention or reduction of colonic inflammation." 04/22/2015 - "These results suggest that piperine has an anti-inflammatory effect at colorectal sites that is due to down- regulations of the productions and expression of inflammatory mediators and it also reduces FFA induced TLR4 mediated inflammation. " 04/02/2015 - "Piperine, a pungent alkaloid found in the fruits of black pepper plants, has diverse physiological effects, including the ability to inhibit immune cell-mediated inflammation. " 01/01/2015 - "Finally, our results demonstrated the ability of piperine to antagonize LPS-mediated inflammation of NP cells and suppression of PG in rat intervertebral disc, suggesting a potential agent for treatment of IDD in future. "
2.	Breast Neoplasms (Breast Cancer) 04/01/2014 - "Piperine enhances the efficacy of TRAIL-based therapy for triple-negative breast cancer cells." 12/01/2013 - "Antitumor efficacy of piperine in the treatment of human HER2-overexpressing breast cancer cells." 02/01/2015 - "In this study, we investigated the effect of piperine on the growth and motility of triple-negative breast cancer (TNBC) cells. " 02/01/2015 - "Piperine inhibits the growth and motility of triple-negative breast cancer cells." 12/01/2013 - "Our findings suggest that piperine may be a potential agent for the prevention and treatment of human breast cancer with HER2 overexpression. "
3.	Obesity 09/25/2014 - "Mitigating efficacy of piperine in the physiological derangements of high fat diet induced obesity in Sprague Dawley rats." 09/25/2014 - "This study was aimed to evaluate anti-obesity effects of piperine on high fat diet (HFD) induced obesity in rats. " 09/25/2014 - "After induction of obesity, piperine was supplemented in different doses (20, 30 and 40mg/kgb.wt) through HFD for 42days to experimental rats. " 04/18/2012 - "Overall, these results suggest that piperine, a major component of black pepper, attenuates fat cell differentiation by down-regulating PPARγ activity as well as suppressing PPARγ expression, thus leading to potential treatment for obesity-related diseases." 05/01/2011 - "The present study was undertaken to explore the effect of piperine in obesity-induced dyslipidemia. "
4.	Infection 07/01/2014 - "Protective efficacy of piperine was tested in a mice infection model of M. " 12/01/2010 - "By using a systemic murine model of infection, we established that CUR and piperine, when administered together, caused a significant fungal load reduction (1.4log10) in kidneys of Swiss mice. " 03/01/2004 - "The size distribution of formulations ranged from 200 to 885 nm. Piperine reduced the parasite burden in liver and spleen by 38% and 31% after 15 days post infection respectively. " 10/01/2011 - "The combination of piperine with mupirocin in a dermal infection model of mice showed better in vivo efficacy when compared with the commercially available formulation of 2 % mupirocin." 07/01/2014 - "Piperine a trans-trans isomer of 1-piperoyl-piperidine was evaluated for its immunomodulatory activity to enhance the efficacy of rifampicin in a murine model of Mycobacterium tuberculosis infection. "
5.	Chromosome Aberrations (Chromosome Abnormalities) 01/01/2008 - "Oral pretreatment of curcumin (80 mg/kg b.w), piperine (50 mg/kg b.w), and curcumin (80 mg/kg b.w) + piperine (50 mg/kg b.w), respectively, for 5 days, significantly reduced the frequency of MnPCEs and the percentage of chromosomal aberrations in the bone marrow of hamsters. " 10/01/2007 - "Antimutagenic effects of piperine on cyclophosphamide-induced chromosome aberrations in rat bone marrow cells." 10/01/2007 - "The results demonstrated that piperine at a dose of 100 mg/kg body weight gave a statistically significant reduction in cyclophosphamide-induced chromosomal aberrations. "

Related Drugs and Biologics

1.	Curcumin
2.	Indomethacin (Indometacin)
3.	Carbon Monoxide
4.	Collagen
5.	Immunoglobulin E (IgE)
6.	Histamine (Histamine Dihydrochloride)
7.	Caerulein (Ceruletide)
8.	Alkaloids
9.	piperlonguminine
10.	NG-Nitroarginine Methyl Ester (L-NAME)

Related Therapies and Procedures

1.	Heterologous Transplantation (Xenotransplantation)
2.	Nanospheres
3.	Oral Administration
4.	Ligation
5.	Intraperitoneal Injections