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phthiocol

antihemorrhagic antibiotic isolated from Mycobacterium tuberculosis; structure

Also Known As:

2-hydroxy-3-methyl-1,4-naphthoquinone

Networked: 3 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Polycyclic Aromatic Hydrocarbons: 2020
        Naphthalenes: 18
        Naphthoquinones: 418
        phthiocol: 3
- Quinones: 434
  - Naphthoquinones: 418
    - phthiocol: 3
Polycyclic Compounds: 6
- Polycyclic Aromatic Hydrocarbons: 2020
  - Naphthalenes: 18
    - Naphthoquinones: 418
      - phthiocol: 3

Related Diseases

1.	Teratocarcinoma 11/15/2022 - "The most obvious finding to emerge from this study is that the usually very chemosensitive CH1/PA-1 teratocarcinoma cells showed resistance to these phthiocol-based organometallics in comparison to the usually less chemosensitive SW480 colon carcinoma cells, which pilot experiments suggest as being related to NQO1 activity."
2.	Carcinoma (Carcinomatosis) 11/15/2022 - "The most obvious finding to emerge from this study is that the usually very chemosensitive CH1/PA-1 teratocarcinoma cells showed resistance to these phthiocol-based organometallics in comparison to the usually less chemosensitive SW480 colon carcinoma cells, which pilot experiments suggest as being related to NQO1 activity."
3.	Mitochondrial Diseases (Mitochondrial Disease) 11/21/2022 - "Vitamin K3, phthiocol, and metal complex 4 successfully inhibited the enzymatic activity of human topoisomerase II. The multifunctionality of any anticancer agent influencing apoptosis, mitochondrial dysfunction, the effect on the cell cycle, and cell proliferation is crucial for defining the prognosis and precise treatment of cancer."
4.	Neoplasms (Cancer) 11/21/2022 - "Vitamin K3, phthiocol, and metal complex 4 successfully inhibited the enzymatic activity of human topoisomerase II. The multifunctionality of any anticancer agent influencing apoptosis, mitochondrial dysfunction, the effect on the cell cycle, and cell proliferation is crucial for defining the prognosis and precise treatment of cancer."
5.	Lung Neoplasms (Lung Cancer) 11/21/2022 - "The metal complexes of phthiocol (pht) were evaluated for their anticancer activity against MCF-7 (breast) and A549 (lung) cancer cell lines. "

Related Drugs and Biologics

1.	Coordination Complexes
2.	Vitamin K 3 (Menadione)
3.	Nitrogen
4.	Metals
5.	Type II DNA Topoisomerases (Topoisomerase II)
6.	Antineoplastic Agents (Antineoplastics)