phenyl biguanide

RN given refers to parent cpd

Also Known As:

1-phenylbiguanide; N-phenyl-N'-guanylguanidine; phenyl biguanide dihydrochloride; phenyl biguanide hydrochloride; phenyl biguanide monohydrochloride; phenyl diguanide; phenylbiguanide; phenyldiguanide; imidodicarbonimidic diamide, N-phenyl-

Networked: 81 relevant articles (1 outcomes, 4 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amidines: 14
  - Guanidines: 29
    - Biguanides: 1107
      - phenyl biguanide: 81

Experts

1.	Deshpande, Shripad B: 3 articles (01/2016 - 02/2011)
2.	Akella, Aparna: 2 articles (01/2016 - 10/2014)
3.	Tiwari, Anil K: 2 articles (01/2016 - 10/2014)
4.	Cabral, A M: 2 articles (03/2011 - 05/2000)
5.	Malinowska, Barbara: 2 articles (01/2011 - 03/2003)
6.	Hamon, Michel: 2 articles (05/2009 - 09/2002)
7.	Laguzzi, Raul: 2 articles (05/2009 - 09/2002)
8.	Sévoz-Couche, Caroline: 2 articles (05/2009 - 09/2002)
9.	Woods, R L: 2 articles (12/2007 - 01/2001)
10.	Brognara, Fernanda: 1 article (01/2021)

Related Diseases

1.	Bradycardia 12/20/2000 - "Reflex bradycardia evoked by intravenous phenylbiguanide was eliminated in NTS-lesioned rats, verifying the lesion's effectiveness. " 01/01/2022 - "Application of phenylbiguanide every 10 min close to the right atrium induced consistent depressor and bradycardia reflex responses. " 07/01/2011 - "2. Dose-dependent BJR bradycardia was evoked by the 5-HT(3) receptor agonist, phenylbiguanide (range 5-89 μg/kg), in conscious instrumented adult sheep (n = 6). " 03/01/2011 - "We report here the effects of intracisternal (ic) administration of selective 5-HT(2A/2B) antagonists on the vagal bradycardia elicited by activation of the von Bezold-Jarisch reflex with phenylbiguanide. " 12/01/2007 - "Phenyl biguanide (PBG), injected via the right atrium in bolus doses of 1-5 mug to evoke the von Bezold-Jarisch reflex, caused a dose-related increase in CVM activity and bradycardia. "
2.	Hypotension (Low Blood Pressure) 01/01/2022 - "Rats supplemented with VitD 15 IU/day presented exaggerated bradycardic responses to the intravenous injection of phenylbiguanide (PBG, 5 μg/kg of b.w.) compared to Control animals, despite the similar hypotension in both groups. " 10/01/2014 - "Jugular venous injection of phenyldiguanide (PDG) in anaesthetized rats produced reflex bradycardia, hypotension and apnoea. " 07/05/2011 - "Phenylbiguanide (PBG 5 μg/kg, i.v.) for activation BJR, produced bradycardia (-317±22 bpm for CN vs. -372±16 bpm for MN) and hypotension (-57±4 mm Hg for CN vs. -54±6 mm Hg for MN. " 09/01/2010 - "Stimulation of pulmonary C fibre receptors by phenylbiguanide (PBG, 5-HT(3) agonist) produces hypotension, bradycardia and tachypnoea or apnoea. " 07/01/1996 - "Intra-atrial administration of phenylbiguanide has been shown to trigger, through the stimulation of vagal afferent C-fibers, reflex bradycardia, hypotension, and sympathoinhibition classically known as the Bezold-Jarisch (B-J) reflex (O. "
3.	Pulmonary Edema 02/01/2011 - "Since, histamine also increases capillary permeability, this study was undertaken to evaluate whether MBT venom utilizes histamine to produce pulmonary edema and augmentation of cardio-respiratory reflexes evoked by phenylbiguanide (PBG). " 01/01/2016 - "Therefore, we hypothesized that morphine blocks the MBT venom-induced augmentation of phenyldiguanide (PDG) reflex and pulmonary edema. " 01/01/2016 - "Morphine blocks the Mesobuthus tamulus venom-induced augmentation of phenyldiguanide reflex and pulmonary edema in anesthetized rats."
4.	Myocardial Ischemia (Ischemic Heart Diseases) 01/01/2011 - "The aim of the present study was to elucidate the influence of acute experimental myocardial ischemia on the reflex bradycardia induced by anandamide and phenylbiguanide, agonists of the TRPV1 and 5-HT(3) receptors, respectively. "
5.	Diabetic Ketoacidosis (Ketoacidosis, Diabetic) 10/15/1971 - "[Clinico-therapeutical trials of a combination of insulin and phenylbiguanide with delayed action in diabetic acidosis]."

Related Drugs and Biologics

1.	Histamine (Histamine Dihydrochloride)
2.	Venoms
3.	Serotonin Receptor Agonists (Serotonin Receptor Agonist)
4.	Insulin (Novolin)
5.	anandamide (arachidonylethanolamide)
6.	Serotonin (5 Hydroxytryptamine)
7.	5-HT3 Serotonin Receptors (5 HT3 Receptor)
8.	Urethane (Ethyl Carbamate)
9.	Phenylephrine (Neo-Synephrine)
10.	Irritants (Vesicants)

Related Therapies and Procedures

1.	Injections
2.	Intravenous Injections
3.	Vagotomy
4.	Intravenous Administration
5.	Therapeutics