perfluoropentane (perflenapent)

inert expander of tissue spaces, liquid at room temperature, but gaseous at body temperatures; used in experimental eye surgery; structure

Also Known As:

perflenapent; 1,1,1,2,2,3,3,4,4,5,5,5-dodecafluoropentane; 1,1,1,2,2,3,4,5,5,5-decafluoropentane; 1,1,1,2,3,4,4,5,5,5-decafluoropentane; 2,3-dihydroperfluoropentane; 2H,3H-perfluoropentane; EchoGen; NVX-108; dodecafluoropentane

Networked: 77 relevant articles (8 outcomes, 20 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Halogenated Hydrocarbons: 42
    - Fluorinated Hydrocarbons: 4
      - Fluorocarbons: 1209
        perfluoropentane: 77
  - Acyclic Hydrocarbons
    - Alkanes: 241
      - Pentanes
        perfluoropentane: 77

Experts

1.	Wang, Zhigang: 5 articles (09/2021 - 01/2017)
2.	Hao, Lan: 4 articles (09/2021 - 01/2017)
3.	Unger, Evan C: 4 articles (10/2019 - 01/2012)
4.	Brown, A T: 4 articles (10/2015 - 10/2013)
5.	Culp, W C: 4 articles (10/2015 - 10/2013)
6.	Skinner, R D: 4 articles (10/2015 - 10/2013)
7.	Cao, Zhong: 3 articles (10/2021 - 01/2017)
8.	Liu, Jie: 3 articles (10/2021 - 01/2017)
9.	Wang, Wei: 3 articles (10/2021 - 01/2017)
10.	Li, Pan: 3 articles (01/2021 - 01/2017)

Related Diseases

1.	Neoplasms (Cancer) 03/01/2022 - "Histological analysis showed higher necrotic area within the tumor with perfluoropentane nanodroplets. " 12/01/2020 - "Corrigendum to 'Development of 64Cu-loaded Perfluoropentane Nanodroplet: A Potential Tumor Theragnostic Nano-carrier and Dual-Modality PET-Ultrasound Imaging Agents' [Ultrasound Med Biol 46 (2020) 2775-2784]." 10/01/2020 - "Development of 64Cu-loaded Perfluoropentane Nanodroplet: A Potential Tumor Theragnostic Nano-carrier and Dual-Modality PET-Ultrasound Imaging Agents." 02/01/2015 - "Results showed that tumor PO2 increased in NVX-108 treated mice up to 400% with the greatest effect seen at the highest dose of 0.6 cc/kg. Tumor growth was significantly reduced in both treatment groups relative to controls (p < 0.0001). " 02/01/2015 - "Direct tumor PO2 measurements were performed in 9 mice treated with 0.3, 0.45 and 0.6 cc/kg NVX-108 (2% w/vol DDFP) in order to assess the dose dependent increase in tumor PO2. "
2.	Breast Neoplasms (Breast Cancer) 08/01/2014 - "The nanoshells were filled with perfluoropentane and injected directly into excised human breast tumor, and intravenously (IV) into healthy rabbits and Py8119 tumor-bearing athymic nude mice. " 01/01/2023 - "To study the effect of cellulose nanofiber (CNF)-shelled perfluoropentane (PFP) droplets on the cell viability of 4T1 breast cancer cells with or without the addition of non-encapsulated paclitaxel. " 12/12/2018 - "Herein, we report a magnetically targeted and photothermal-triggered drug release nanotheranostics system based on superparamagnetic iron oxide (Fe3O4), IR780, doxorubicin (DOX), and perfluoropentane (PFP) entrapped poly-lactide- co-glycolide (PLGA) nanoparticles (IR780/Fe3O4@PLGA/PFP/DOX NPs) for triple-modal imaging-guided synergistic therapy of breast cancer. " 12/01/2020 - "The purpose of this study was to evaluate the efficacy of laser-induced near-infrared (NIR) PFP/Gd-DTPA/ICG@PLGA NPs (PGINPs) in US/MR imaging and regimen for breast cancer; gadolinium-DTPA (Gd-DTPA), perfluoropentane (PFP) and indocyanine green (ICG) were wrapped in the poly (lactic-co-glycolic) acid (PLGA) shell membrane via a double emulsion approach. " 01/01/2017 - "In this study, we developed tumor-targeting ultrasound-triggered phase-transition nanodroplets AHNP-PFP-TNDs comprising a perfluorinated poly(amino acid) C11F17-PAsp (DET) as a core for simultaneously loading perfluoropentane (PFP) and nucleic acids, and a polyanionic polymer PGA-g-PEG-AHNP as the shell for not only modifying the surface of nanodroplets but also introducing an anti-Her2/neu peptide (AHNP) aiming to targeted treatment of Her2-overexpressing breast cancer. "
3.	Infarction (Infarctions) 11/01/2014 - "The average area of infarct in comparison to the ventricle for the control mice was 29.3±0.04% compared to 11.7±0.02% for the dodecafluoropentane-treated mice. " 11/01/1995 - "Myocardial contrast echocardiography using intravenous dodecafluoropentane accurately defined myocardial area at risk and infarct size. " 11/01/2014 - "The use of dodecafluoropentane in this murine model of myocardial infarction showed a 60% reduction in infarct size (p<0.01). " 02/01/2015 - "Dodecafluoropentane emulsion delays and reduces MRI markers of infarction in a rat stroke model: a preliminary report." 01/01/2012 - "Dodecafluoropentane emulsion decreases infarct volume in a rabbit ischemic stroke model."
4.	Stroke (Strokes) 01/01/2014 - "Dodecafluoropentane emulsion (DDFPe), given IV one hour after stroke, has been shown to greatly reduce the percent stroke volume (%SV) in rabbits. " 01/01/2014 - "Dodecafluoropentane Emulsion (DDFPe) Decreases Stroke Size and Improves Neurological Scores in a Permanent Occlusion Rat Stroke Model." 10/01/2015 - "Dodecafluoropentane Emulsion Extends Window for tPA Therapy in a Rabbit Stroke Model." 02/01/2015 - "Dodecafluoropentane emulsion delays and reduces MRI markers of infarction in a rat stroke model: a preliminary report." 10/01/2015 - "Dodecafluoropentane emulsion (DDFPe) nanodroplets are exceptional oxygen transporters and can protect ischemic brain in stroke models 24 h without reperfusion. "
5.	Myocardial Infarction 11/01/2014 - "The use of dodecafluoropentane in this murine model of myocardial infarction showed a 60% reduction in infarct size (p<0.01). " 01/01/2019 - "Imaging assessment of cardioprotection mediated by a dodecafluoropentane oxygen-carrier administered during myocardial infarction." 12/01/2014 - "Dodecafluoropentane emulsion elicits cardiac protection against myocardial infarction through an ATP-Sensitive K+ channel dependent mechanism."

Related Drugs and Biologics

1.	Emulsions
2.	Doxorubicin (Adriamycin)
3.	Folic Acid (Vitamin M)
4.	Polymers
5.	Indocyanine Green (Cardio-Green)
6.	Oxygen (Dioxygen)
7.	Liposomes (Liposome)
8.	Gadolinium DTPA (Magnevist)
9.	Polylactic Acid-Polyglycolic Acid Copolymer
10.	Fluorocarbons

Related Therapies and Procedures

1.	Therapeutics
2.	Precision Medicine
3.	Microbubbles
4.	Lasers (Laser)
5.	Drug Therapy (Chemotherapy)