sulfan blue (patent blue V)

widely used to visualize lymph vessels for lymphography; structure

Also Known As:

patent blue V; (4-(alpha-(p-(diethylamino)phenyl)-2,4-disulfobenzylidene)-2,5-cyclohexadien-1-ylidene)diethylammonium hydroxide inner salt sodium salt; Blue URS; Blue VRS; C.I. acid blue 1; C.I. acid blue 3; acid blue 1; acid blue 3; alphazurine 2G; bleu patent V; blue patent violet; disulfine blue; disulphine blue; ethanaminium, n-(4-((4-(diethylamino)phenyl)(2,4-disulfophenyl)methylene)-2,5-cyclohexadien-1-ylidene)-n-ethyl-, hydroxide, inner salt, sodium salt; patent blue violet; sodium 4-((4-(diethylamino)phenyl)(4-(diethyliminio)cyclohexa-2,5-dien-1-ylidene)methyl)benzene-1,3-disulphonate; sulphan blue; N-(4-((4-(diethylamino)phenyl)(2,4-disulfophenyl)methylene)-2,5-cyclohexadien-1-ylidene)-N-ethylethanaminium, hydroxide, inner salt, sodium salt

Networked: 119 relevant articles (2 outcomes, 11 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amines: 4871
  - Aniline Compounds: 46
    - Rosaniline Dyes: 73
      - sulfan blue: 119

Experts

1.	Goyal, A: 4 articles (12/2010 - 07/2004)
2.	Mansel, R E: 4 articles (12/2010 - 07/2004)
3.	ALMANAC Trialists Group: 4 articles (09/2006 - 07/2004)
4.	Goyal, Amit: 4 articles (09/2006 - 10/2004)
5.	Mansel, Robert E: 4 articles (09/2006 - 10/2004)
6.	Newcombe, Robert G: 4 articles (09/2006 - 10/2004)
7.	Chang, Yeun-Chung: 3 articles (01/2019 - 04/2016)
8.	Newcombe, R G: 3 articles (04/2010 - 07/2004)
9.	Abbaci, Muriel: 2 articles (02/2022 - 12/2016)
10.	De Leeuw, Frederic: 2 articles (02/2022 - 12/2016)

Related Diseases

1.	Peritoneal Neoplasms 12/01/2016 - "We performed a correlative study with the histological gold standard on ex vivo human specimens from 25 patients operated for peritoneal carcinomatosis; 70 specimens were stained by topical application with ICG or patent blue V and then imaged with a probe-based confocal laser endomicroscope. " 12/01/2016 - "Patent blue V and indocyanine green for fluorescence microimaging of human peritoneal carcinomatosis using probe-based confocal laser endomicroscopy."
2.	Colonic Neoplasms (Colon Cancer) 10/27/2012 - "We observed three features after the injection of Patent Blue V in the intestinal loops: (1) Macroscopically healthy terminal ileum of patients with CD or colon cancer showed thin lymphatic vessels linearly directed toward the mesentery; (2) In mild lesions in which the intestinal wall did not reach 8 mm of thickness, we observed short, wide and tortuous lymphatic vessels directed longitudinally along the intestinal axis toward disease-free areas and then transversally toward the mesentery; and (3) Injection in the severely affected lesions, that had a thickness of the intestinal wall over 10 mm, did not show any feature of lymphatic vessels at least on the subserosal surface. " 09/01/2006 - "RT-PCR and immunohistochemical evaluation of sentinel lymph nodes after in vivo mapping with Patent Blue V in colon cancer patients." 08/01/2004 - "Using Patent Blue V, it is possible to identify the sentinel node in most patients with colon cancer. " 09/01/2011 - "A randomized controlled trial was carried out in which patients undergoing resection for colonic cancer were allocated to patent V blue or no patent blue V dye submucosal injection of the operative specimen. " 02/01/2010 - "Sixty-nine patients with biopsy-proven cancer of the colon and rectum underwent SLN mapping according to a protocol involving the ex vivo submucosal and peritumoral injection of 2-4 ml of Patent Blue V dye. "
3.	Breast Neoplasms (Breast Cancer) 07/01/2019 - "Diagnostic application of patent blue V in sentinel lymph node biopsy for breast cancer - Is it time for a change?" 03/01/2005 - "Patent blue vital (patent blue V; Laboratoire Guerbet, France) is used to identify the sentinel node during surgery for invasive breast cancer. " 01/01/2013 - "Hypersensitivity reactions to Patent Blue V in breast cancer surgery: a prospective multicentre study." 01/01/2013 - "An increasing number of immediate hypersensitivity reactions (HSR) have been reported after the use of Patent Blue V (PBV) for breast cancer surgery. " 03/01/2010 - "For comparison we recruited 12 healthy control subjects who then underwent skin testing to patent blue V. Six cases of patent blue V allergy were identified, all occurring during sentinel lymph node identification for breast carcinoma. "
4.	Hypersensitivity (Allergy) 03/01/2010 - "On the basis of our experience of patent blue V allergy, we propose a diagnostic protocol that can be safely and reliably utilised in centres equipped for allergy testing." 03/01/2010 - "We gathered all cases of patent blue V allergy that had been seen and diagnosed in the Department of Allergy, Addenbrooke's Hospital over a 3-year period. " 03/01/2010 - "Individual case reports of allergy to patent blue V have been described in the medical literature since the 1960s. " 07/01/1982 - "[Allergic reactions to patent blue violet: mechanisms, frequency and treatment]." 09/01/1977 - "Allergic reaction to Patent Blue Violet during lymphography."
5.	Colorectal Neoplasms (Colorectal Cancer) 01/01/2009 - "We used the dying method with Patent Blue V. An algorithm was worked out for sentinel mapping in colorectal cancer. " 09/01/2011 - "The study aimed to assess whether the ex vivo injection of patent blue V dye would increase lymph node yield in operative specimens of colorectal cancer. " 09/01/2011 - "Lymph node yield following injection of patent blue V dye into colorectal cancer specimens." 01/01/2006 - "We used the dye-method with Patent Blue V to patients with verificated colorectal cancer. " 11/01/2002 - "Patent Blue V dye 2.5% was injected intra-operatively into left-sided colorectal carcinomas prior to resection in 19 patients. "

Related Drugs and Biologics

1.	Coloring Agents (Dyes)
2.	sulfan blue (patent blue V)
3.	Colloids (Colloid)
4.	Dextrans (Dextran)
5.	Methylene Blue (Methylthioninium Chloride)
6.	iso-sulfan blue (Lymphazurin)
7.	Albumins
8.	Indocyanine Green (Cardio-Green)
9.	Immunoglobulin E (IgE)
10.	Polymethyl Methacrylate (Sol)

Related Therapies and Procedures

1.	Lasers (Laser)
2.	Hysterectomy
3.	Subcutaneous Injections
4.	Ligation
5.	Therapeutics