pachypodol

new flavonoid isolated from Pachypodanthium confine; from Chinese herb Agastache folium; structure

Also Known As:

3,7,3'-quercetol trimethyl ether-5,4'-dihydroxy-; 4',5-dihydroxy-3,3',7-trimethoxyflavone; Ro 09-0179; Ro 090179; Ro-09-0179; Ro-090179; 4H-1-Benzopyran-4-one, 5-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-3,7-dimethoxy-

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrans: 130
    - Benzopyrans: 195
      - Chromones: 159
        Flavonoids: 9773
        Flavonols: 321
        Quercetin: 5087
        pachypodol: 4
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzopyrans: 195
      - Chromones: 159
        Flavonoids: 9773
        Flavonols: 321
        Quercetin: 5087
        pachypodol: 4

Experts

1.	Ali, Husne-Ara: 1 article (12/2008)
2.	Borkowski, Tomasz: 1 article (12/2008)
3.	Chowdhury, A K Azad: 1 article (12/2008)
4.	Nahar, Lutfun: 1 article (12/2008)
5.	Rahman, Abul K M: 1 article (12/2008)
6.	Sarker, Satyajit D: 1 article (12/2008)

Related Diseases

1.	Infections 10/01/1982 - "Ro 09-0298 (4',5-diacetyloxy-3,3',7-trimethoxyflavone), an orally active derivative of Ro 09-0179, prevented coxsackievirus (B1) infection in mice. " 06/01/1997 - "Ro-090179 (Ro), a flavonoid isolated from the herb Agastache rugosa, provokes the specific swelling and disruption of the Golgi complex and strongly inhibits poliovirus infection. " 06/01/1997 - "Poliovirus infection and expression of the poliovirus protein 2B provoke the disassembly of the Golgi complex, the organelle target for the antipoliovirus drug Ro-090179."
2.	Colonic Neoplasms (Colon Cancer) 12/01/2008 - "Pachypodol, a flavonol from the leaves of Calycopteris floribunda, inhibits the growth of CaCo 2 colon cancer cell line in vitro." 12/01/2008 - "While the general toxicity of pachypodol was determined by the brine shrimp lethality assay, the cytotoxic potential of this flavonoid has been evaluated by the Promega's CellTiter 96 Non-Radioactive Cell Proliferation Assay using the CaCo-2 colon cancer cell line (IC(50) = 185.6 microM). "
3.	COVID-19 01/01/2022 - "Molecular docking showed that I-SPD, Pachypodol and Vestitol in XFBD played a role in treating COVID-19 by acting on NLRP3, CSF2, and relieve the clinical symptoms of SARS-CoV-2 infection. "

Related Drugs and Biologics

1.	Flavonoids
2.	Proteins (Proteins, Gene)
3.	vestitol
4.	Promega
5.	3-hydroxyflavone