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norcocaine

N-demethylated cocaine; RN given refers to (1R-(exo,exo))-isomer

Also Known As:

norcocaine acetate, (1R-(exo,exo))-isomer; norcocaine hydrochloride; norcocaine, (1R-(2-endo,3-exo))-isomer

Networked: 7 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Zhan, Chang-Guo: 3 articles (11/2020 - 01/2014)
2.	Zhan, Max: 3 articles (11/2020 - 01/2014)
3.	Zheng, Fang: 3 articles (11/2020 - 01/2014)
4.	Zheng, Xirong: 2 articles (11/2020 - 06/2014)
5.	Hou, Shurong: 2 articles (06/2014 - 01/2014)
6.	Chen, Xiabin: 1 article (11/2020)
7.	Zhang, Ting: 1 article (11/2020)

Related Diseases

1.	Cocaine-Related Disorders (Cocaine Addiction) 01/01/2014 - "Further kinetic modelling has suggested that CocH3 with an identical concentration with that of the endogenous BChE in human plasma can effectively eliminate both cocaine and norcocaine in a simplified kinetic model of cocaine abuse." 06/15/2014 - "Further kinetic modelling has suggested that E12-7 with an identical concentration as that of the endogenous BChE in human plasma can effectively eliminate (-)-cocaine, cocaethylene and norcocaine in simplified kinetic models of cocaine abuse and overdose associated with the concurrent use of cocaine and alcohol." 03/01/1994 - "The psychostimulant drug of abuse, cocaine (benzoylecgonine methyl ester), is rapidly metabolized by cleavage of its two ester groups, to give benzoylecgonine (BE) and ecgonine methyl ester, and by N-demethylation, to give N-norcocaine (NC). " 11/01/2020 - "Hence, a truly valuable cocaine-metabolizing enzyme for cocaine abuse/overdose treatment should be effective for the hydrolysis of not only cocaine, but also its metabolites norcocaine, cocaethylene, and norcocaethylene. "
2.	Ganglion Cysts (Ganglion) 01/15/1977 - "The local anesthetic effects of cocaine and one of its main metabolites norcocaine, were investigated comparatively on isolated ganglion cells of the marine gastropod, Aplysia californica. "
3.	Shock 06/01/1999 - "There were no gender-related differences in the doses of norcocaine required to produce circulatory collapse; however, there were significant gender-related differences in the norcocaine tissue-to-plasma concentration ratios (T:P ratios). " 06/01/1999 - "In contrast, female rats had a greater percentage of norcocaine in the plasma at circulatory collapse after acute cocaine administration. " 06/01/1999 - "Arterial blood samples as well as heart, liver, and brain tissues were obtained at circulatory collapse for the measurement of concentrations of norcocaine as well as cocaine and its major metabolites. " 06/01/1999 - "Norcocaine or cocaine was administered intravenously at a rate of 2 mg/kg/min until circulatory collapse. "
4.	Respiratory Insufficiency (Respiratory Failure) 11/01/1995 - "Pentobarbital anesthesia enhanced the respiratory depression and suppressed or delayed the onset of convulsions from norcocaine and cocaine infusion. "

Related Drugs and Biologics

1.	Cocaine (Cocaine HCl)
2.	cocaethylene
3.	Enzymes
4.	norcocaethylene
5.	Pentobarbital (Nembutal)
6.	Esters
7.	Local Anesthetics
8.	ecgonine methyl ester
9.	benzoylecgonine

Related Therapies and Procedures

1.	Anesthesia