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murexine

muscle relaxant; structure

Also Known As:

beta- (4-imidazolyl)acryloylcholine; choline, chloride, imidazole-4-acrylate

Networked: 4 relevant articles (1 outcomes, 0 trials/studies)

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Bio-Agent Context: Research Results

Organic Chemicals: 133

Related Diseases

1.	Contracture 09/01/1957 - "Murexine (urocanoylcholine, [2-beta-imidazol-4(5)-ylacryloyloxyethyl]trimethylammonium chloride hydrochloride) produced a contracture like acetylcholine in the frog rectus and a neuromuscular block in the rat diaphragm which was not relieved by neostigmine but was antagonized by hexamethonium. "
2.	Ganglion Cysts (Ganglion) 09/01/1958 - "DMAC has been shown to be a ganglion stimulating and neuromuscular blocking agent generally similar, in potency and properties, to murexine. " 03/01/1958 - "Murexine (urocanoylcholine, [2-beta-imidazol-4(5)-ylacryloyloxyethyl] trimethylammonium bromide) has been shown to possess ganglion stimulating and neuromuscular blocking actions in cat, dog and rat. "
3.	Spasm (Spasms) 01/01/1970 - "Four other imidazoles tested, L-histidine, murexine, dihydromurexine and imidazolecarboxylcholine, were ineffective; so was the pyrazole ring isomer of histamine, betazole.4. The inhibitory action of histamine persisted after adrenoceptor blockade by phentolamine and pronethalol and after prior reserpinization of the guineapigs.5. The inhibitory action of histamine was also obtained after ganglionic paralysis by hexamethonium or dimethylphenylpiperazinium but was antagonized specifically by nicotine.6. On atropinized preparations of the longitudinal muscle from the guinea-pig descending colon histamine exerted, at most, an insignificant inhibitory effect on the tetanic spasms."
4.	Paralysis (Palsy) 01/01/1970 - "Four other imidazoles tested, L-histidine, murexine, dihydromurexine and imidazolecarboxylcholine, were ineffective; so was the pyrazole ring isomer of histamine, betazole.4. The inhibitory action of histamine persisted after adrenoceptor blockade by phentolamine and pronethalol and after prior reserpinization of the guineapigs.5. The inhibitory action of histamine was also obtained after ganglionic paralysis by hexamethonium or dimethylphenylpiperazinium but was antagonized specifically by nicotine.6. On atropinized preparations of the longitudinal muscle from the guinea-pig descending colon histamine exerted, at most, an insignificant inhibitory effect on the tetanic spasms."

Related Drugs and Biologics

1.	Hexamethonium (Hexamethonium Bromide)
2.	Neostigmine (Neostigmine Bromide)
3.	Chlorides
4.	Acetylcholine (Acetylcholine Chloride)
5.	Adrenergic Receptors (Adrenergic Receptor)
6.	Phentolamine (Z-Max)
7.	Nicotine
8.	Neuromuscular Blocking Agents
9.	Imidazoles
10.	Histidine (L-Histidine)